Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel D. De Carvalho"'
Publikováno v:
Nature Reviews Cancer. 19:151-161
DNA methylation inhibitors have become the mainstay for treatment of certain haematological malignancies. In addition to their abilities to reactivate genes, including tumour suppressors, that have acquired DNA methylation during carcinogenesis, they
Autor:
Michael J. Johnston, Parinaz Mehdipour, Douglas J. Mahoney, Katrina Ellestad, Christopher J Gafuik, Jennifer A. Chan, Ana Nikolic, Daniel D. De Carvalho, Nicoletta Ninkovic, Steven J.M. Jones, Xueqing Lun, Anna Bobyn, Peter B. Dirks, Francesca Maule, Yaoqing Shen, Darren J. Derksen, N. Daniel Berger, Donna L. Senger, Duncan K. Brownsey, Marco Gallo, Franz J. Zemp, Sajid A. Marhon
SUMMARYSelf-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe58287f85fb3fd3054c88f6e24aee0
https://doi.org/10.1101/2021.02.23.432465
https://doi.org/10.1101/2021.02.23.432465
Autor:
Johann Hitzler, Laura García-Prat, Sabrina A. Smith, Gabriela Krivdova, Daniel D. De Carvalho, Olga I. Gan, Maria Azkanaz, Leonardo Salmena, Maian Roifman, Elvin Wagenblast, Karen Chong, David Chitayat, John E. Dick, Alex Murison, Eric R. Lechman, Martino Gabra, Jessica McLeod, Sarah K Cutting, Jean C.Y. Wang, Sajid A. Marhon, Joana Araújo, Patrick Shannon, Michelle Chan-Seng-Yue
Children with Down syndrome have a 150-fold increased risk of developing myeloid leukemia, but the mechanism of predisposition is unclear. As Down syndrome leukemogenesis initiates during fetal development, we characterized the cellular context of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5102fa236e1ee48daea0d4391094e5d2
https://doi.org/10.1101/2020.11.29.402800
https://doi.org/10.1101/2020.11.29.402800
Autor:
Mathieu Lupien, Yulia Jitkova, Michael Mullokandov, Helen Loo Yau, Rima Al-awar, James R. Hawley, Rose Hurren, Troy Ketela, S. Kim, Veronique Voisin, Neil MacLean, Daniel D. De Carvalho, Mark D. Minden, Geethu E. Thomas, Val A. Fajardo, Ahmed Aman, Zhenyue Hao, Zaza Khuchua, G. Wei Xu, Gary D. Bader, Richard P. Bazinet, Juan J. Aristizabal Henao, Mingjing Xu, Paul J. LeBlanc, Ayesh K. Seneviratne, Steven M. Claypool, Steven M. Chan, Xiaoming Wang, Atan Gross, Aaron D. Schimmer, Ken D. Stark, David Sharon, Raphaël Chouinard-Watkins, Danny V. Jeyaraju, Caitlin Schafer, Marcela Gronda
Summary Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b74e60e809d7c98db8697836fef410
https://europepmc.org/articles/PMC7137093/
https://europepmc.org/articles/PMC7137093/
Autor:
Benjamin Ellezam, Paul Guilhamon, Peter W. Lewis, Nicolas De Jay, Nada Jabado, Josie Ursini-Siegel, Sameer Agnihotri, Mathieu Lupien, Peter B. Dirks, Paul Lasko, Ashot S. Harutyunyan, Stephen C. Mack, Damien Faury, Robert F. Koncar, Carol C.L. Chen, Paolo Salomoni, Dylan M. Marchione, Shriya Deshmukh, Daniel D. De Carvalho, Leonie G. Mikael, Alexander G. Weil, Claudia L. Kleinman, Melissa K. McConechy, Brian Krug, Kelsey C. Bertrand, Benjamin A. Garcia, Sima Khazaei, Cheryl H. Arrowsmith
Publikováno v:
Cancer Cell
Cancer cell 35(5), 782-797.e8 (2019). doi:10.1016/j.ccell.2019.04.004
Cancer cell 35(5), 782-797.e8 (2019). doi:10.1016/j.ccell.2019.04.004
High-grade gliomas (HGG) defined by histone 3 K27M driver mutations exhibit global loss of H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping repressive and active chromatin landscapes. We generated tumor-derived isog
Autor:
Minkui Luo, Daniel D. De Carvalho, Masoud Vedadi, Suzanne Ackloo, Andrew M. Lewis, Jian Jin, Matthieu Schapira, Tiago Medina, Colby Zaph, H. Ümit Kaniskan, Jeffrey P. Northrop, Yudao Shen, Jing Liu, Jennifer A. Ward, Dalia Barsyte-Lovejoy, Kilian Huber, David Smil, Sebastian Scheer, Cheryl H. Arrowsmith, Fengling Li, Peter Brown, Paul L. Richardson
SUMMARYProtein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96df785a4e892e1537e723a9d29daae
https://doi.org/10.1101/260638
https://doi.org/10.1101/260638
Autor:
Felipe Campos de Almeida, Beatriz Morancho, David Allard, David Roulois, Marcus O. Butler, Rajat Singhania, Ilias Ettayebi, Sandra Pommey, Parinaz Mehdipour, Shu Yi Shen, Helen Loo Yau, Daniel D. De Carvalho, Christian Klein, Gustavo Amarante-Mendes, Joaquín Arribas, John Stagg, Ankur Chakravarthy, Tiago Medina
Recent studies have shown that DNA methyltransferase inhibitors (DNMTi) can induce IRF7 activation and Type I/III interferon signaling through dsRNA-mediated viral mimicry in cancer cells. By performing a large pan-cancer analysis using TCGA data, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7ac63c7b3484c785a169d6afa09104
https://doi.org/10.1101/197236
https://doi.org/10.1101/197236
Publikováno v:
Cancer Research. 73:677-677
Gene silencing mediated by aberrant promoter DNA hypermethylation is one of the key features of cancer. Although such modification is heritable, its dynamic nature and reversibility through pharmacological interventions make it an attractive therapeu