Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Bin Xiao"'
Autor:
Dan-Dan Li, Dong-Hao Bai, Jee H. Jung, Bin Xiao, Ying Wang, Na Zhao, Shang-Wu Jin, Li-Dong Sun, Eun La Kim
Publikováno v:
Biomolecules & Therapeutics
In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib to the ligand-binding domain of P
Autor:
Xijun Wang, Hong-Bin Xiao, Ai-Xia Ju, Yong Hu, Jiao Zhao, Guang Xu, Qing-Song Qie, Qiu-Hong Li
Publikováno v:
World Journal of Traditional Chinese Medicine, Vol 7, Iss 3, Pp 332-338 (2021)
Objective: To explore the mechanism underlying the effect of Panax notoginseng saponins (PNS) on the pharmacokinetics of nifedipine (NF) in rats. Materials and Methods: Twenty-four rats were randomly divided into blank (BL) group, PNS group, NF group
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 122-132 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 122-132 (2021)
Most recombinant adeno-associated virus (AAV) capsids utilized in liver gene therapy have significant levels of pre-existing neutralizing antibodies in the human population. These neutralizing factors limit the patient pools eligible for receiving AA
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1046-1051
Beta-asarone (β-Asarone), the major component of Acorus tatarinowii Rhizoma, has been proved to be muti-pharmacological activities including anti-inflammation, and which is effective in protecting the central nervous system. However, the effect of
Publikováno v:
Clinical Biochemistry. 74:60-68
Background Colorectal cancer (CRC) is one of the most common cancers worldwide, and emerging lines of evidence have implicated circular RNAs (circRNAs), a novel class of endogenous noncoding RNAs, in CRC development. However, whether plasma circRNAs
Autor:
Jian-Ying Chen, Sheng-Zhi Jiang, Xia Guo, Qiao Li, Jie-Rou Huang, Hui Rao, Li-Hua Zhang, Bin Xiao
Publikováno v:
Autoimmunity. 54(7)
The dysregulated microRNAs (miRNAs) are implicated in the malignancy of lupus nephritis (LN). This work aims to analyse the effect and mechanism of miR-146b-5p in lipopolysaccharides (LPS)-induced model of LN in vitro. The serum samples of LN patient
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Autor:
Ke-Yu Chen, Xiao-Ming Zhang, Pan Li, Zhu Jiang, Zhi-Yang Xia, Chengyi Shen, Qian Xia, Tao Cheng, Chunrong Zhu, Lei Zhong, Bin Xiao, Changqiang Wu
Publikováno v:
Journal of medicinal chemistry. 64(13)
Liver-specific contrast agents (CAs) can improve the Magnetic resonance imaging (MRI) detection of focal and diffuse liver lesions by increasing the lesion-to-liver contrast. A novel Mn(II) complex, Mn-BnO-TyrEDTA, with a lipophilic group-modified et
Autor:
Yongjun Zhang, Jingjing Tan, Qiqi Huang, Jiangying Zeng, Ge Wang, Shuang Chen, Bin Xiao, jing yao, Tao Feng
Publikováno v:
International journal of biological macromolecules. 187
An efficient extraction method of Auricularia auricula polysaccharides (AAPs) by neutral protease was developed and optimized by response surface methodology. AAPs were graded by stepwise ethanol precipitation, the fraction with high recovery rate an
Autor:
Yutao Chen, Ge Wang, Zhiyu Fang, Bin Xiao, Jingyi Gu, Meng Shen, Jia Li, Tao Feng, Yongjun Zhang, Weimin Wang
Publikováno v:
Food & Function. 10:5531-5543
Caenorhabditis elegans is an important model organism for studying stress response mechanisms and identifying genetic pathways that influence longevity. The present study was designed to explore the in vivo-antioxidant potential and the probable mech