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Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice
Autor:
Olle Söder, Luise Landreh, Jan Nedergaard, Nina Atanassova, Natasa Petrovic, Mi Hou, Daniel Edgar, Irina G. Shabalina, Kjell Hultenby, Natalia Gibanova, Konstantin Svechnikov
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(8)
Point mutations and deletions of mitochondrial DNA (mtDNA) accumulate in tissues during aging in animals and humans and are the basis for mitochondrial diseases. Testosterone synthesis occurs in the mitochondria of Leydig cells. Mitochondrial dysfunc