Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tanja D de Gruijl"'
Autor:
Martino Ambrosini, Sanne Duinkerken, Juan J. Garcia-Vallejo, Tanja D. de Gruijl, Lisa Rutte, Hakan Kalay, Sophie K. Horrevorts, Yvette van Kooyk
Publikováno v:
Duinkerken, S, Horrevorts, S K, Kalay, H, Ambrosini, M, Rutte, L, de Gruijl, T D, Garcia-Vallejo, J J & van Kooyk, Y 2019, ' Glyco-dendrimers as intradermal anti-tumor vaccine targeting multiple skin DC subsets ', Theranostics, vol. 9, no. 20, pp. 5797-5809 . https://doi.org/10.7150/thno.35059
Theranostics, 9, 5797-5809
Theranostics
Theranostics, 9(20), 5797-5809. Ivyspring International Publisher
Theranostics, 9, 20, pp. 5797-5809
Theranostics, 9, 5797-5809
Theranostics
Theranostics, 9(20), 5797-5809. Ivyspring International Publisher
Theranostics, 9, 20, pp. 5797-5809
Contains fulltext : 215802.pdf (Publisher’s version ) (Open Access) The human skin is an attractive anti-tumor vaccination site due to the vast network of dendritic cell (DC) subsets that carry antigens to the draining lymph nodes and stimulate tum
Autor:
Martino Ambrosini, Cynthia M. Fehres, Sven C. M. Bruijns, W.W.J. Unger, Sanne Duinkerken, Tanja D. de Gruijl, Yvette van Kooyk, Hakan Kalay, Sandra J. van Vliet, Juan J. Garcia-Vallejo
Publikováno v:
Fehres, C M, Duinkerken, S, Bruijns, S C, Kalay, H, van Vliet, S J, Ambrosini, M, de Gruijl, T D, Unger, W W, Garcia-Vallejo, J J & van Kooyk, Y 2017, ' Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells ', Cellular Immunology, vol. 14, no. 4, pp. 360-370 . https://doi.org/10.1038/cmi.2015.87
Cellular Immunology, 14(4), 360-370. Academic Press Inc.
Cellular Immunology, 14(4), 360-370. Academic Press Inc.
The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin contains several antigen-presenting cell subsets with specialized functions. In particular,
Autor:
Tanja D. de Gruijl, Krista Ouwehand, Rik J. Scheper, Susan Gibbs, D. Oosterhoff, Melanie Breetveld
Publikováno v:
Journal of Investigative Dermatology, 131, 418-425. Nature Publishing Group
Ouwehand, K, Oosterhoff, D, Breetveld, M, Scheper, R J, de Gruijl, T D & Gibbs, S 2011, ' Irritant-induced migration of Langerhans cells coincides with an IL-10-dependent switch to a macrophage-like phenotype. ', Journal of Investigative Dermatology, vol. 131, pp. 418-425 . https://doi.org/10.1038/jid.2010.336
Ouwehand, K, Oosterhoff, D, Breetveld, M, Scheper, R J, de Gruijl, T D & Gibbs, S 2011, ' Irritant-induced migration of Langerhans cells coincides with an IL-10-dependent switch to a macrophage-like phenotype. ', Journal of Investigative Dermatology, vol. 131, pp. 418-425 . https://doi.org/10.1038/jid.2010.336
Langerhans cells (LCs) migrate after topical exposure of the skin to irritants, despite the supposed independence of irritant contact dermatitis from adaptive immunity. Whereas allergen-activated LCs are known to migrate to the draining lymph nodes (
Autor:
Tanja D. de Gruijl, Malin Lindstedt, Kim L Kroeze, Rik J. Scheper, Susan Gibbs, Carl A.K. Borrebaeck, Rieneke van de Ven, Saskia J. A. M. Santegoets
Publikováno v:
Journal of Leukocyte Biology, 84(1), 143-151. FASEB
Santegoets, S J A M, Gibbs, S, Kroeze, K L, van de Ven, R, Scheper, R J, Borrebaeck, C A, de Gruijl, T D & Lindstedt, M 2008, ' Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions ', Journal of Leukocyte Biology, vol. 84, no. 1, pp. 143-151 . https://doi.org/10.1189/jlb.1107750
Santegoets, S J A M, Gibbs, S, Kroeze, K L, van de Ven, R, Scheper, R J, Borrebaeck, C A, de Gruijl, T D & Lindstedt, M 2008, ' Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions ', Journal of Leukocyte Biology, vol. 84, no. 1, pp. 143-151 . https://doi.org/10.1189/jlb.1107750
In human skin, two main populations of dendritic cells (DC) can be discriminated: dermal DC (DDC) and epidermal Langerhans cells (LC). Although extensively studied, most of the knowledge about DDC and LC phenotype and function is obtained from studyi
Autor:
Nina Kok, John P. Veluchamy, Henk M.W. Verheul, Fenna Bohme, Tanja D. de Gruijl, Jan Spanholtz, Hans J. van der Vliet
Publikováno v:
Journal of Clinical Oncology. 34:e14525-e14525
e14525Background: Resistance to epidermal growth factor receptor (EGFR) targeting therapy is a major limitation in metastatic colorectal cancer (mCRC). Moreover, NK cells in solid tumor patients ar...
Autor:
Daniëlle A.M. Heideman, A. Marijne Heeren, Jan Spanholtz, Jaap D. H. van Eendenburg, Tanja D. de Gruijl, Gemma G. Kenter, Ekaterina S. Jordanova, Henk M.W. Verheul, Hans J. van der Vliet, John P. Veluchamy
Publikováno v:
Journal of Clinical Oncology. 34:e14526-e14526
e14526Background: Cetuximab monotherapy is not effective in epidermal growth factor receptor (EGFR) positive cervical cancer patients. NK cells synergize with cetuximab through antibody dependent c...
Publikováno v:
European Journal of Immunology, 40(7), 2026-2034. Wiley-VCH Verlag
Ouwehand, K, Scheper, R J, de Gruijl, T D & Gibbs, S 2010, ' Epidermis-to-dermis migration of immature Langerhans cells upon topical irritant exposure is dependent on CCL2 and CCL5 ', European Journal of Immunology, vol. 40, no. 7, pp. 2026-2034 . https://doi.org/10.1002/eji.200940150
Ouwehand, K, Scheper, R J, de Gruijl, T D & Gibbs, S 2010, ' Epidermis-to-dermis migration of immature Langerhans cells upon topical irritant exposure is dependent on CCL2 and CCL5 ', European Journal of Immunology, vol. 40, no. 7, pp. 2026-2034 . https://doi.org/10.1002/eji.200940150
Skin irritation is generally not considered to be an immunological event; however, alterations in the density of Langerhans cells (LC) in the epidermis do occur, which is indicative of LC migration. In this study, we investigated the migration of LC
Autor:
Maureen E. Taylor, Lot de Witte, Donna Fluitsma, Saskia J. A. M. Santegoets, Marein A. W. P. de Jong, Tanja D. de Gruijl, Teunis B. H. Geijtenbeek
Publikováno v:
de Jong, M A W P, de Witte, L, Santegoets, S J A M, Fluitsma, D, Taylor, M E, de Gruijl, T D & Geijtenbeek, T B H 2010, ' Mutz-3-derived Langerhans cells are a model to study HIV-1 transmission and potential inhibitors ', Journal of Leukocyte Biology, vol. 87, no. 4, pp. 637-643 . https://doi.org/10.1189/jlb.0809577
Journal of leukocyte biology, 87(4), 637-643. FASEB
Journal of Leukocyte Biology, 87(4), 637-643. FASEB
Journal of leukocyte biology, 87(4), 637-643. FASEB
Journal of Leukocyte Biology, 87(4), 637-643. FASEB
Mutz-3 derived Langerhans cells are a model to study HIV-1 transmission and to screen potential inhibitors. Sexual transmission is the primary route of HIV-1 infection, and DC subsets are thought to be involved in viral dissemination to T cells. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc67a90a26f15d9482a746ca5a8b8ca
https://research.vumc.nl/en/publications/980fd046-b9a0-414a-8f13-5c0131ad8fbb
https://research.vumc.nl/en/publications/980fd046-b9a0-414a-8f13-5c0131ad8fbb
Autor:
Donna Fluitsma, Lot de Witte, Marein A. W. P. de Jong, Teunis B.H. Geijtenbeek, Marjorie Pion, Yvette van Kooyk, Tanja D. de Gruijl, Alexey A. Nabatov, Vincent Piguet
Publikováno v:
Nature medicine, 13(3), 367-371. Nature Publishing Group
de Witte, L, Nabatov, A, Pion, M, Fluitsma, D, de Jong, M A W P, de Gruijl, T, Piguet, V, van Kooyk, Y & Geijtenbeek, T B H 2007, ' Langerin is a natural barrier to HIV-1 transmission by Langerhans cells ', Nature Medicine, vol. 13, no. 3, pp. 367-71 . https://doi.org/10.1038/nm1541
Nature Medicine, 13(3), 367-71. Nature Publishing Group
de Witte, L, Nabatov, A, Pion, M, Fluitsma, D, de Jong, M A W P, de Gruijl, T, Piguet, V, van Kooyk, Y & Geijtenbeek, T B H 2007, ' Langerin is a natural barrier to HIV-1 transmission by Langerhans cells ', Nature Medicine, vol. 13, no. 3, pp. 367-71 . https://doi.org/10.1038/nm1541
Nature Medicine, 13(3), 367-71. Nature Publishing Group
Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIG