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Autor:
Aamir Ahmad, Gjumrakch Aliev, Guang Yang, Valentin Pavlov, Ilgiz Gareev, Ozal Beylerli, Aferin Beilerli
Publikováno v:
Seminars in Cancer Biology. 83:242-252
Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules (ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, an interest in understanding their regulatory importance is
Autor:
Bernice Leung, Thomas Dodd, Chunli Yan, Jun Xu, Ivaylo Ivanov, Dong Wang, Juntaek Oh, Jina Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Transcription-coupled repair is essential for the removal of DNA lesions from the transcribed genome. The pathway is initiated by CSB protein binding to stalled RNA polymerase II. Mutations impairing CSB function cause severe genetic disease. Yet, th
Autor:
Wei Dai, Junhong Wu, Lu Xie, Lingxia Chen, Fuhua Xie, Xinqiang Wu, Shenglan Liu, Liangmei He, Zhiping Liu
Publikováno v:
Cellular and Molecular Life Sciences. 78:8261-8281
Colorectal cancer (CRC) is the leading cause of cancer-related mortality worldwide, which makes it urgent to identify novel therapeutic targets for CRC treatment. In this study, DHX9 was filtered out as the prominent proliferation promoters of CRC by
Publikováno v:
Nat Protoc
Precise control of gene expression requires the coordinated action of multiple factors at cis-regulatory elements. We recently developed single-molecule footprinting to simultaneously resolve the occupancy of multiple proteins including transcription
Autor:
Christian Dienemann, Isaac Fianu, Olexandr Dybkov, Henning Urlaub, Ying Chen, Patrick Cramer, Andreas Linden
Publikováno v:
Science. 374:883-887
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. We report the structure of the pretermination complex containing the human Int
Publikováno v:
Aging (Albany NY)
UBB+1 is a mutated version of ubiquitin B peptide caused by a transcriptional frameshift due to the RNA polymerase II "slippage". The accumulation of UBB+1 has been linked to ubiquitin-proteasome system (UPS) dysfunction and neurodegeneration. Alzhei
Autor:
Hongyan Wang, Robert G. Roeder, Zhong Chen, Yue Zhao, William Hankey, Alexandre Rosa Campos, Jiaoti Huang, Qianben Wang, Jeff Groth, Furong Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
RNA Polymerase II (Pol II) transcriptional recycling is a mechanism for which the required factors and contributions to overall gene expression levels are poorly understood. We describe an in vitro methodology facilitating unbiased identification of
Autor:
Beatrix Bradford, Chunyuan Jin
Publikováno v:
Semin Cancer Biol
Pre-mRNA processing of the replication-dependent canonical histone mRNAs requires an endonucleolytic cleavage immediately after a conserved stem loop structure which occurs before RNA Pol II encounters any poly(A) signal. Thus, in contrast to all oth
Autor:
Nina Jovic, Nicolas L. Fawzi, Abigail M. Janke, Jeetain Mittal, Wai Shing Tang, Anastasia C Murthy, Theodora Myrto Perdikari, Da Hee Seo
Publikováno v:
Nat Struct Mol Biol
The RNA-binding protein FUS (Fused in Sarcoma) mediates phase separation in biomolecular condensates and functions in transcription by clustering with RNA polymerase II. Specific contact residues and interaction modes formed by FUS and the C-terminal
Publikováno v:
Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1683-1688 (2021)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Crosstalk between post-translational modifications of histone proteins influences the regulation of chromatin structure and gene expression. Among such crosstalk pathways, the best-characterized example is H2B monoubiquitination-mediated H3K4 and H3K