Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sergio Valente"'
The polypharmacology strategy of multi-targeting drugs acting on different biological pathways is capturing the researchers' attention, particularly in cancer. The simultaneous inhibition of two or more targets by drug combination or by a single 'hyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a53b9c4a96ad01347c52a810b779bc
http://hdl.handle.net/11573/1416968
http://hdl.handle.net/11573/1416968
Autor:
Davide Gentilini, Giovanna Lattanzi, Sergio Valente, Daniel Remondini, Anna Maria Di Blasio, Emanuela Scarano, Elisabetta Mattioli, Antonello Mai, Davide Andrenacci, Katia Scotlandi, Giulia Piaggio, Sabino Prencipe, Cecilia Garofalo, Lucia Cicchilitti
Publikováno v:
Aging Cell
Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson–Gilford progeria, a severe LMNA‐linked syndrome associated with bone resorption, cardiovascular disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bceaee753399cd4eefc2ee077e234f
http://hdl.handle.net/11585/663880
http://hdl.handle.net/11585/663880
Autor:
Irene Bozzoni, Stefania Straino, Claudia Colussi, Antonella Farsetti, Matteo Vecellio, Francesco Spallotta, Jessica Rosati, Sergio Valente, Maurizio C. Capogrossi, Alfredo Pontecorvi, Antonello Mai, Silvia Tardivo, Julie Martone, Carlo Gaetano, Simona Nanni
Publikováno v:
The Journal of biological chemistry
288 (2013): 22915–22929. doi:10.1074/jbc.M113.484337
info:cnr-pdr/source/autori:Francesco Spallotta 1; Silvia Tardivo 2; Simona Nanni 3,7; Jessica D. Rosati 1; Stefania Straino 2,4 ; Antonello Mai 5; Matteo Vecellio1; Sergio Valente 5; Maurizio C. Capogrossi 3; Antonella Farsetti 7,6; Julie Martone 8; Irene Bozzoni 8; Alfredo Pontecorvi 3; Carlo Gaetano 9; Claudia Colussi 3,7/titolo:Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia/doi:10.1074%2Fjbc.M113.484337/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:22915/pagina_a:22929/intervallo_pagine:22915–22929/volume:288
288 (2013): 22915–22929. doi:10.1074/jbc.M113.484337
info:cnr-pdr/source/autori:Francesco Spallotta 1; Silvia Tardivo 2; Simona Nanni 3,7; Jessica D. Rosati 1; Stefania Straino 2,4 ; Antonello Mai 5; Matteo Vecellio1; Sergio Valente 5; Maurizio C. Capogrossi 3; Antonella Farsetti 7,6; Julie Martone 8; Irene Bozzoni 8; Alfredo Pontecorvi 3; Carlo Gaetano 9; Claudia Colussi 3,7/titolo:Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia/doi:10.1074%2Fjbc.M113.484337/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:22915/pagina_a:22929/intervallo_pagine:22915–22929/volume:288
Histone deacetylase inhibitors (DIs) are promising drugs for the treatment of several pathologies including ischemic and failing heart where they demonstrated efficacy. However, adverse side effects and cardiotoxicity have also been reported. Remarka
Autor:
Ilaria Cerbara, Dante Rotili, Antonello Mai, Silvio Massa, Riccardo Pezzi, Rino Ragno, Silvia Simeoni, Sergio Valente
Publikováno v:
Medicinal Research Reviews. 25:261-309
The reversible histone acetylation and deacetylation are epigenetic phenomena that play critical roles in the modulation of chromatin topology and the regulation of gene expression. Aberrant transcription due to altered expression or mutation of gene
Autor:
Carola Eleonora Parolin, Natalia Calonghi, Sergio Valente, Antonello Mai, Vincenza Andrisano, Lanfranco Masotti, Marina Naldi
The goal of the present work is to establish a correlation between the degree of histone post-translational modifications and the effects caused by treatment of HT29 colon cancer cells with class I-selective (MS-275 and MC1855), class II-selective (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf9b6f86d34007f843e403d507f8ae7
http://hdl.handle.net/11585/82835
http://hdl.handle.net/11585/82835
Autor:
Antonello Mai, Sergio Valente
Publikováno v:
Expert opinion on therapeutic patents. 24(4)
Histone deacetylases (HDACs) play an important role in mediating the expression of genes involved in cancer and non-cancer diseases. Overexpression of these enzymes has been shown in several types of cancer and some enzyme isoforms were described as
Autor:
Claudia Colussi, Fabio Martelli, Antonello Mai, Sergio Valente, Maurizio C. Capogrossi, Simona Artuso, Carlo Gaetano, Isabella Manni, Antonella Farsetti, Francesco Spallotta, Simona Nanni, Stefania Straino, Chiara Cencioni, Jessica Rosati, Giulia Piaggio
Publikováno v:
Journal of biological chemistry (Online) 288 (2013): 11004–11012. doi:10.1074/jbc.M112.441816
info:cnr-pdr/source/autori:Spallotta Francesco1; Cencioni Chiara1; Straino Stefania2; Nanni Simona3; Rosati Jessica4; Artuso Simona5; Manni Isabella5; Colussi Claudia3;Piaggio Giulia5;Martelli Fabio 6; Valente Sergio7; Mai Antonello7; Capogrossi Maurizio C.2; Farsetti Antonella8; Gaetano Carlo9/titolo:A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair/doi:10.1074%2Fjbc.M112.441816/rivista:Journal of biological chemistry (Online)/anno:2013/pagina_da:11004/pagina_a:11012/intervallo_pagine:11004–11012/volume:288
info:cnr-pdr/source/autori:Spallotta Francesco1; Cencioni Chiara1; Straino Stefania2; Nanni Simona3; Rosati Jessica4; Artuso Simona5; Manni Isabella5; Colussi Claudia3;Piaggio Giulia5;Martelli Fabio 6; Valente Sergio7; Mai Antonello7; Capogrossi Maurizio C.2; Farsetti Antonella8; Gaetano Carlo9/titolo:A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair/doi:10.1074%2Fjbc.M112.441816/rivista:Journal of biological chemistry (Online)/anno:2013/pagina_da:11004/pagina_a:11012/intervallo_pagine:11004–11012/volume:288
In a mouse model of skin repair we found that the class I-IIa histone deacetylase inhibitor trichostatin A accelerated tissue regeneration. Unexpectedly, this effect was suppressed by Sirtinol, a class III histone deacetylase (HDAC) (sirtuin)-selecti
Publikováno v:
Current pharmaceutical design. 15(34)
Neurodegenerative disorders (NDs) such as Huntington's disease, Alzheimer's disease, Parkinson disease, amyotrophic lateral sclerosis, spinal muscular atrophy, Friedreich's ataxia, and others are multi-factorial illnesses, in which many pathways (sti
Autor:
Vincenzo Carafa, Sarah Meade, Maria Tardugno, Antonello Mai, Sergio Valente, Lucia Altucci, Aleksey G. Kazantsev, Angela Nebbioso, Nico Mitro, Emma De Fabiani, Andrea Galmozzi
Publikováno v:
Journal of Medicinal Chemistry
NAD(+)-dependent sirtuin deacetylases have emerged as potential therapeutic targets for treatment of human illnesses such as cancer, metabolic, cardiovascular, and neurodegenerative diseases. The benefits of sirtuin modulation by small molecules have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535750bc0970c138f576921e36930952
http://hdl.handle.net/11573/12799
http://hdl.handle.net/11573/12799
Autor:
Silvio Massa, Antonello Mai, Fabio Manzo, Lucia Altucci, Silvia Simeoni, Rino Ragno, Angela Nebbioso, Floriana De Bellis, Gerald Brosch, Sergio Valente
Publikováno v:
The international journal of biochemistrycell biology. 41(1)
Aroyl-pyrrolyl-hydroxy-amides (APHAs) are a class of synthetic HDAC inhibitors described by us since 2001. Through structure-based drug design, two isomers of the APHA lead compound 1, the 3-(2-benzoyl-1-methyl-1H-pyrrol-4-yl)-N-hydroxy-2-propenamide