Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bin Xiao"'
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 122-132 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 122-132 (2021)
Most recombinant adeno-associated virus (AAV) capsids utilized in liver gene therapy have significant levels of pre-existing neutralizing antibodies in the human population. These neutralizing factors limit the patient pools eligible for receiving AA
Publikováno v:
International Journal of Molecular Medicine
In the present study, we investigated the role of activating transcription factor 6 (ATF6) in the mechanism by which chronic intermittent hypoxia (CIH) increases tolerance to myocardial ischemia/reperfusion (I/R). Experiments were conducted using a r
Autor:
Ze‑Zhou Feng, Zhao Jian, Peng Liu, Ying‑Bin Xiao, Wei‑Kun Jia, Yun Zhu, Liang Zhao, Jingwei Li, Si‑Yi He
Publikováno v:
Molecular Medicine Reports. 12:6903-6910
MicroRNAs (miRs) regulate a number of physiological and pathological processes, including myocardial chronic hypoxia. Previous studies revealed that the expression of miR-146b is increased in vitro and in vivo following the induction of hypoxia. In t
Autor:
Fuli Yao, Jing Li, Xiaofang Zhao, Yong Wang, Ying Cheng, Chunyan Duan, Chunhong Feng, Xianming Xia, Rongyang Dai, Guosong Luo, Wenjing Yu, Mei Wei, Hong Zhou, Bin Xiao
Publikováno v:
Molecular medicine reports. 18(2)
Although activating transcription factor 4 (ATF4) is involved in the regulation of numerous biological functions, whether ATF4 has a direct role in liver injury is unknown. The aim of the present study was to investigate the role of ATF4 in liver inj
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0164105 (2016)
PLoS ONE, Vol 11, Iss 10, p e0164105 (2016)
Increasing evidence has indicated that many microRNAs participate in the development and progression of esophageal cancer and gene expression regulation. MicroRNA-20b (miR-20b) has been reported to be aberrantly expressed in various cancers, but its
Autor:
Pei Juan Lu, Xiao Xiao, Chunping Qiao, Lei Xu, Qi Long Lu, Chi Hsien Wang, Derek J. Blake, Bin Xiao, Elizabeth Keramaris
Publikováno v:
Molecular Therapy. 21(10):1832-1840
Mutations in the FKRP gene are associated with a wide range of muscular dystrophies from mild limb-girdle muscular dystrophy (LGMD) 2I to severe Walker–Warburg syndrome and muscle-eye-brain disease. The characteristic biochemical feature of these d
Autor:
Xiao Xiao, Bin Xiao, H Yan, Chunping Qiao, G F Shen, Dao Wen Wang, Jiangang Jiang, Jianbin Li
Publikováno v:
Gene therapy. 24(3)
Inhibition of myostatin, a negative growth modulator for muscle, can functionally enhance muscle mass and improve glucose and fat metabolism in myostatin propeptide (MPRO) transgenic mice. This study was to investigate whether myostatin inhibition by
Autor:
Chuanxi Cai, Zhenhua Yuan, Ruhang Tang, Juan Li, Bo He, Bin Xiao, Noah Weisleder, Chunping Qiao, Hua Zhu, Xiao Xiao, Christina Mayer, Jianbin Li, Jianjie Ma, Pei-Hui Lin
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 20(4)
Muscular dystrophies (MDs) are caused by genetic mutations in over 30 different genes, many of which encode for proteins essential for the integrity of muscle cell structure and membrane. Their deficiencies cause the muscle vulnerable to mechanical a
Autor:
Taiping Chen, Da-Zhi Wang, Bin Xiao, Yi Zhang, Eric M. Kallin, Xiao Xiao, Anh T. Nguyen, Juan Li, Ronald L. Neppl
Histone methylation plays an important role in regulating gene expression. One such methylation occurs at Lys 79 of histone H3 (H3K79) and is catalyzed by the yeast DOT1 (disruptor of telomeric silencing) and its mammalian homolog, DOT1L. Previous st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b00988126c2f2b76d563dbf99a5eb9
https://europepmc.org/articles/PMC3034901/
https://europepmc.org/articles/PMC3034901/
Autor:
Bo Wu, Mona Shaban, Caryn Cloer, Xiao Xiao, Kanneboyina Nagaraju, Qi Long Lu, Peijuan Lu, Juan Li, Arpana Sali, Bin Xiao
Antisense therapy has been successful to skip targeted dystrophin exon with correction of frameshift and nonsense mutations of Duchenne muscular dystrophy (DMD). Systemic production of truncated but functional dystrophin proteins has been achieved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02017fc3f7438f44c6f3b3d950b33791
https://europepmc.org/articles/PMC3048192/
https://europepmc.org/articles/PMC3048192/