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Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
DNA double-strand breaks are among the most toxic lesions that can occur in a genome and their faithful repair is thus of great importance. Recent findings have uncovered local transcription that initiates at the break and forms a non-coding transcri
Publikováno v:
Nat Protoc
Precise control of gene expression requires the coordinated action of multiple factors at cis-regulatory elements. We recently developed single-molecule footprinting to simultaneously resolve the occupancy of multiple proteins including transcription
Autor:
Christian Dienemann, Isaac Fianu, Olexandr Dybkov, Henning Urlaub, Ying Chen, Patrick Cramer, Andreas Linden
Publikováno v:
Science. 374:883-887
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. We report the structure of the pretermination complex containing the human Int
Publikováno v:
Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1683-1688 (2021)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Crosstalk between post-translational modifications of histone proteins influences the regulation of chromatin structure and gene expression. Among such crosstalk pathways, the best-characterized example is H2B monoubiquitination-mediated H3K4 and H3K
Autor:
Kwang Won Jeong
Publikováno v:
Current Issues in Molecular Biology
Volume 43
Issue 3
Pages 115-1631
Current Issues in Molecular Biology, Vol 43, Iss 115, Pp 1623-1631 (2021)
Volume 43
Issue 3
Pages 115-1631
Current Issues in Molecular Biology, Vol 43, Iss 115, Pp 1623-1631 (2021)
Aryl hydrocarbon receptors (AHRs), a class of ligand-dependent nuclear receptors that regulate cellular responses by inducing the expression of various target genes in response to external signals, are implicated in maintaining retinal tissue homeost
Autor:
Neetu Singh
Publikováno v:
Genomics. 113:3250-3273
Long non-coding RNAs (lncRNAs) are expressed at lower levels than protein-coding genes but have a crucial role in gene regulation. LncRNA is distinct, they are being transcribed using RNA polymerase II, and their functionality depends on subcellular
Autor:
Tamara Phan, Pallab Maity, Christina Ludwig, Lisa Streit, Miltiadis Tsesmelis, Sebastian Iben, Karin Scharffetter-Kochanek, Jens Michaelis
Publikováno v:
Nucleic Acids Research
Ribosome biogenesis is a highly energy-demanding process in eukaryotes which requires the concerted action of all three RNA polymerases. In RNA polymerase II transcription, the general transcription factor TFIIH is recruited by TFIIE to the initiatio
Autor:
Zhongming Zhao, Junjie Chen, Chao Wang, Zhen Chen, Mengfan Tang, Xu Feng, Dan Su, Guangsheng Pei, Mrinal Srivastava
Publikováno v:
Nucleic Acids Research
Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we perfo
Publikováno v:
FEBS Letters. 595:1933-1948
Activated and promoter-bound heat-shock transcription factor 1 (HSF1) induces RNA polymerase II recruitment upon heat shock, and this is facilitated by the core Mediator in Drosophila and yeast. Another Mediator module, CDK8 kinase module (CKM), cons
Autor:
James Chuang, Magdalena Murawska, Dan Spatt, Dhawal Jain, Olga V. Viktorovskaya, Fred Winston, L. Stirling Churchman, Francheska Lopez-Rivera, Peter J. Park, Natalia I. Reim
Publikováno v:
Genes Dev
Histone chaperones are critical for controlling chromatin integrity during transcription, DNA replication, and DNA repair. Three conserved and essential chaperones, Spt6, Spn1/Iws1, and FACT, associate with elongating RNA polymerase II and interact w