Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jiri Bartek"'
Autor:
Tiit Mathiesen, Jiri Bartek, Marianne Juhler, Andrea Daniela Maier, Helle Broholm, Frank Eriksson, Heidi Ugleholdt
Publikováno v:
Neurosurgical Review. 43:643-653
We investigated possible clinical and histopathological prognostic factors in a malignant meningioma cohort with comprehensive long-term population-based follow-up data. Twenty-four consecutive patients treated surgically for malignant meningioma at
Autor:
Ke Cong, Jiri Bartek, Graeme C. Smith, Sharon B. Cantor, Jinhyuk Bhin, Marieke van de Ven, Miguel Andújar-Sánchez, Mariana Paes Dias, Vivek Tripathi, Stefano Annunziato, Eleni Maria Manolika, Cor Lieftink, Roderick L. Beijersbergen, Jos Jonkers, Ingrid van der Heijden, Jirina Bartkova, Arnab Ray Chaudhuri, Sanjiban Chakrabarty, Sven Rottenberg, Ewa Gogola, Panagiotis Galanos
Publikováno v:
Mol Cell
Molecular Cell, 81(22), 4692-4708.e9. Cell Press
Molecular Cell, 81(22), 4692-4708.e9. Cell Press
SUMMARYInhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, preclinical and clinical research with PARPi has reveal
Autor:
Ernest Dodoo, Georges Sinclair, Davide Valentini, Elisabeth Sandberg, Inti-Harvey Peredo, Qingda Meng, Jiri Bartek, Xiaohua Luo, Liu Zhenjiang, Martin Rao, Esther Schoutrop, Markus Maeurer, Thomas Poiret, Anna von Landenberg
Publikováno v:
EBioMedicine
EBioMedicine, Vol 23, Iss C, Pp 20-24 (2017)
EBioMedicine, Vol 23, Iss C, Pp 20-24 (2017)
Background Patients with advanced malignancies, e.g. lung cancer, ovarian cancer or melanoma, frequently present with brain metastases. Clinical presentation and disease progression of cancer is in part shaped by the interaction of the immune system
Publikováno v:
British journal of haematology. 184(2)
Autor:
Pavel Moudry, Christopher J. Lord, Jiri Bartek, Rachel Brough, Alan Ashworth, Zdenek Hodny, Jessica Frankum
Publikováno v:
Ashworth, Alan; Frankum, J; Moudry, P; Brough, R; Hodny, Z; Bartek, J; et al.(2015). Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/24f5w3zj
Oncotarget
Oncotarget
// Jessica Frankum 1,* , Pavel Moudry 2,* , Rachel Brough 1 , Zdenek Hodny 3 , Alan Ashworth 1 , Jiri Bartek 2,3 and Christopher J. Lord 1 1 The CRUK Gene Function Laboratory and Breakthrough Breast Cancer Research Centre, The Institute of Cancer Res
Autor:
Jiri Lukas, Kenji Watanabe, Sugiko Watanabe, Vyacheslav Akimov, Jirina Bartkova, Blagoy Blagoev, Jiri Bartek
Publikováno v:
Watanabe, S, Watanabe, K, Akimov, V, Bartkova, J, Blagoev, B, Lukas, J & Bartek, J 2013, ' JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks ', Nature Structural and Molecular Biology, vol. 20, no. 12, pp. 1425-1433 . https://doi.org/10.1038/nsmb.2702
Chromatin ubiquitylation flanking DNA double-strand breaks (DSBs), mediated by RNF8 and RNF168 ubiquitin ligases, orchestrates a two-branch pathway, recruiting repair factors 53BP1 or the RAP80-BRCA1 complex. We report that human demethylase JMJD1C r
Autor:
Jiri Bartek, Nils Brünner, Peter Nørgaard, Ida Marie Heeholm Sønderstrup, Sune Boris Nygård, Dorte Linnemann, Hans Jørgen Nielsen, Jan Stenvang, Tim Svenstrup Poulsen, L. Riis
Publikováno v:
Molecular oncology. 9(6)
Topoisomerase 1 (TOP1) and 2A (TOP2A) are potential predictive biomarkers for irinotecan and anthracycline treatment, respectively, in colorectal cancer (CRC), and we have recently reported a high frequency of gene gain of the TOP1 and TOP2A genes in
Autor:
Jirina Bartkova, Jiri Bartek, Premysl Slezak, Carlos A. Rubio, Lars H. Thomassen, Edgar Jaramillo, Minna Thullberg
Publikováno v:
Gastroenterology. 120:1680-1688
Background & Aims: The G1/S-phase controlling mechanism known as the RB pathway is commonly deregulated in human malignancies. Here, the abundance and localization of key components of the retinoblastoma (RB) pathway were determined in exophytic and
Publikováno v:
Electrophoresis. 20:372-381
The members of the 'pocket protein' family, comprising the retinoblastoma tumor suppressor (pRB) and its relatives, p107 and p130, negatively regulate cell proliferation and modulate fundamental biological processes including embryonic development, d
Publikováno v:
International Journal of Cancer. 66:732-737
The cyclin-dependent kinase 7 (CDK7) represents the 40-kDa catalytic subunit of the CDK-activating kinase, the enzyme responsible for activatory phosphorylation of multiple CDKs controlling G1, S and G2/M phases of the cell cycle. Here, we surveyed a