Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Richard A, Koup"'
Autor:
Filippo Maria Tucci, Yiannis Dimopoulos, Constantinos Petrovas, Richard A. Koup, Rita De Vito, Paolo Rossi, Nicola Cotugno, Giulia Macchiarulo, Salvatore Rocca, Maria R. Castrucci, Sandeep Narpala, Donato Amodio, Adrian B. McDermott, Paolo Palma
Generation of Ag-specific humoral responses requires the orchestrated development and function of highly specialized immune cells in secondary lymphoid organs. We used a multiparametric approach combining flow cytometry, confocal microscopy, and hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc31bc4f9cc3290bea393025399d4404
http://hdl.handle.net/2108/226941
http://hdl.handle.net/2108/226941
Autor:
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev, John T. Patton
Publikováno v:
mBio
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activatio
Autor:
Emily C. Smith, Xiaoyong Sun, Michael Y. Gerner, Netanya G. Sandler, Daniel C. Douek, Srinivas S. Rao, Amanda C. Poholek, Takuya Yamamoto, Kaska Wloka, Li Pan, Robert A. Seder, Kristin L. Boswell, Georgia D. Tomaras, Richard A. Koup, Elias K. Haddad, Constantinos Petrovas, David R. Ambrozak, Mario Roederer, J. Katherina Timmer, Ronald N. Germain, S. Munir Alam, Jason M. Brenchley
Publikováno v:
Journal of Clinical Investigation. 122:3281-3294
CD4 T follicular helper (TFH) cells interact with and stimulate the generation of antigen-specific B cells. TFH cell interaction with B cells correlates with production of SIV-specific immunoglobulins. However, the fate of TFH cells and their partici
Autor:
Katie Ewer, Tommy Rampling, Navin Venkatraman, Georgina Bowyer, Danny Wright, Teresa Lambe, Egeruan B. Imoukhuede, Ruth Payne, Sarah Katharina Fehling, Thomas Strecker, Nadine Biedenkopf, Verena Krähling, Claire M. Tully, Nick J. Edwards., Emma M. Bentley, Dhanraj Samuel, Geneviève Labbé, Jing Jin, Malick Gibani., Alice Minhinnic, Morven Wilkie, Ian Poulton, Natalie Lella, Rachel Roberts, Felicity Hartnell, Carly Bliss, Kailan Sierra-Davidson, Jonathan Powlson, Eleanor Berrie, Richard Tedder, B. Chir., Francois Roman, Iris De Ryck, Alfredo Nicosia, Nancy J. Sullivan, Daphne A. Stanley, Olivier T. Mbaya, Julie E. Ledgerwood, Richard M. Schwartz, Loredana Siani, Stefano Colloca, Antonella Folgori, Stefania Di Marco, Riccardo Cortese, Edward Wright, Stephan Becker, Barney S. Graham, Richard A. Koup, Myron M. Levine, Ariane Volkmann, Paul Chaplin, Andrew J. Pollard, Simon J. Draper, D. Phil., W. Ripley Ballou, Alison Lawrie, Sarah C. Gilbert, and Adrian V. S. Hill
BACKGROUND\ud The West African outbreak of Ebola virus disease that peaked in 2014 has caused more than 11,000 deaths. The development of an effective Ebola vaccine is a priority for control of a future outbreak.\ud \ud METHODS\ud In this phase 1 stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180dc9091c76e4ca78fdb439784cfb18
https://westminsterresearch.westminster.ac.uk/download/73fc5235cecfad936d01e4885891d2bdbd8509ccc9118034132a348b6eac7ac2/444979/nejmoa1411627.pdf
https://westminsterresearch.westminster.ac.uk/download/73fc5235cecfad936d01e4885891d2bdbd8509ccc9118034132a348b6eac7ac2/444979/nejmoa1411627.pdf
Autor:
Brigitte Autran, Rémi Cheynier, Yin Xu, Adrien Six, Arnaud Moris, Angeline Rouers, Lucie Colineau, Assia Samri, Alejandra Urrutia, Takuya Yamamoto, Anthony D. Kelleher, Stéphanie Graff-Dubois, Richard A. Koup, Sylvain Cardinaud, Karim Dorgham, Pierre-Grégoire Coulon, Anne Hosmalin, Eric Oksenhendler, John Zaunders, Hang-Phuong Pham
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
International audience; Follicular helper T (Tfh) cells within secondary lymphoid organs control multiple steps of B cell maturation and antibody (Ab) production. HIV-1 infection is associated with an altered B cell differentiation and Tfh isolated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b99955d4a70eff404e532fbe2a1260
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
Autor:
Srinivas S. Rao, Jason Hataye, Keyun Wang, Joseph P. Casazza, Tongqing Zhou, Lan Wu, Zhi Yong Yang, Amarendra Pegu, Wei Shi, Richard A. Koup, John Paul Todd, Peter D. Kwong, Gary J. Nabel, Ivelin S. Georgiev, Xiaoti Guo, Xuejun Chen, Mangaiarkarasi Asokan, Sijy O'Dell, John R. Mascola
Publikováno v:
Nature Communications
The treatment of AIDS with combination antiretroviral therapy (cART) remains lifelong largely because the virus persists in latent reservoirs. Elimination of latently infected cells could therefore reduce treatment duration and facilitate immune reco
Autor:
Julie E, Ledgerwood, Chih-Jen, Wei, Zonghui, Hu, Ingelise J, Gordon, Mary E, Enama, Cynthia S, Hendel, Patrick M, McTamney, Melissa B, Pearce, Hadi M, Yassine, Jeffrey C, Boyington, Robert, Bailer, Terrence M, Tumpey, Richard A, Koup, John R, Mascola, Gary J, Nabel, Barney S, Graham, Phyllis, Zaia
Publikováno v:
The Lancet. Infectious Diseases
Summary Background Because the general population is largely naive to H5N1 influenza, antibodies generated to H5 allow analysis of novel influenza vaccines independent of background immunity from previous infection. We assessed the safety and immunog
Autor:
Mario Roederer, Richard A. Koup, David A. Ambrozak, Melody G. Duvall, Sarah Rowland-Jones, Assan Jaye, Melissa L. Precopio, Andrew J. McMichael, Hilton Whittle
Publikováno v:
European Journal of Immunology. 38:350-363
HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4(+) T cell help in most infected subjects. Thus, HIV-2 provides a unique natural human model in which to inve
Autor:
Constantinos Petrovas, Sara H. Morgan, Simon J. Davis, Elzbieta Tryniszewska, David Price, Genoveffa Franchini, Joseph J. Mattapallil, Christof Geldmacher, Emma Gostick, Valentina Cecchinato, Monica Vaccari, Daniel C. Douek, David R. Ambrozak, Mario Roederer, Richard A. Koup
Publikováno v:
Blood. 110:928-936
Programmed death-1 (PD-1) is a critical mediator of virus-specific CD8+ T-cell exhaustion. Here, we examined the expression of PD-1 on simian immunodeficiency virus (SIV)-specific CD8+ T cells and its possible involvement in regulation of cytokine pr
Publikováno v:
Nature Protocols. 1:1507-1516
We describe here a method for optimizing the use of polychromatic flow cytometry (with up to 17 fluorochromes simultaneously) in surface and intracellular staining of human T lymphocytes. We will highlight and discuss how to procedurally optimize key