Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jacob H"'
Autor:
Carolyn E. Lubner, Kirstin Gutekunst, Jacob H. Artz, Paul W. King, Monika Tokmina-Lukaszewska, Brian Bothner, Marko Boehm, Jens Appel, David W. Mulder
Publikováno v:
The Journal of Biological Chemistry
Cyanobacterial Hox is a [NiFe] hydrogenase that consists of the hydrogen (H2)-activating subunits HoxYH, which form a complex with the HoxEFU assembly to mediate reactions with soluble electron carriers like NAD(P)H and ferredoxin (Fdx), thereby coup
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports
Scientific Reports
The treatment of spinal cord injury (SCI) is a complex challenge in regenerative medicine, complicated by the low intrinsic capacity of CNS neurons to regenerate their axons and the heterogeneity in size, shape and extent of human injuries. For examp
Autor:
Michael Mullokandov, Jacob H. Hanna, Dilshad H. Khan, Atan Gross, Emmanuel Amzallag, Yehudit Zaltsman, Amir Bahat, Vladislav Krupalnik, Coral Halperin, Ayelet Erez, Andres Goldman, Alon Silberman, Aaron D. Schimmer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
The role of mitochondria dynamics and its molecular regulators remains largely unknown during naïve-to-primed pluripotent cell interconversion. Here we report that mitochondrial MTCH2 is a regulator of mitochondrial fusion, essential for the naïve-
Autor:
Yongmei Yu, Adam T. Melvin, Z. Elizabeth Floyd, Ted J. Gauthier, Nora Safa, Dong Liu, Manibarathi Vaithiyanathan, Alireza Rahnama, Jacob H. Pettigrew
Publikováno v:
Biochem Eng J
Deubiquitinating enzyme (DUB)-targeted therapeutics have shown promise in recent years as alternative cancer therapeutics, especially when coupled with proteasome-based inhibitors. While a majority of DUB-based therapeutics function by inhibiting DUB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607e8c876319a14df42ddba49fa8b672
https://europepmc.org/articles/PMC7949241/
https://europepmc.org/articles/PMC7949241/
Publikováno v:
Biochem Eng J
Deubiquitinating enzymes (DUBs) regulate the removal of the polyubiquitin chain from proteins targeted for degradation. Current approaches to quantify DUB activity are limited to test tube-based assays that incorporate enzymes or cell lysates, but no
Autor:
Man Ryul Lee, Byung Hoo Song, Ji Hun Jeong, Jacob H. Hanna, Hyeonseok Shin, Jeong Suk Im, Hyun Kyu Kim, Jaeseok Han, Dong Hun Woo, Jae-Sang Oh, Tae Won Ha
Publikováno v:
Cells
Volume 9
Issue 5
Cells, Vol 9, Iss 1078, p 1078 (2020)
Volume 9
Issue 5
Cells, Vol 9, Iss 1078, p 1078 (2020)
Human pluripotent stem cells (hPSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have a well-orchestrated program for differentiation and self-renewal. However, the structural features of unique proteostatic-maint
Autor:
Xiuling Fu, Jacob H. Hanna, Gang Ma, Jiajian Zhou, Liang Chen, Yunpan Li, Yan Qin, Axel Schambach, Vladislav Krupalnik, Hao Sun, Tian-Tian Zhou, Longqi Liu, Miguel A. Esteban, Fei Gao, Shuhan Chen, Hao Liu, Hui Zhang, Andrew P. Hutchins, Lulu Wang, Bradley W. Doble, Mazid Md. Abdul, Huating Wang, Xichen Bao, Yan Xu, Mengling Jiang, Shahzina Kanwal, Yiwei Lai, Christine Hartmann, Na Li, Xiangpeng Guo, Pengcheng Guo, Jie Yuan, Minghui He, Baoming Qin, David P. Ibañez, Umberto Di Vicino, Xueting Xu, Zhijun Yu, Wenjuan Li, Zhiwei Luo, Giacomo Volpe, Yuan Lv, Ao Jiang, Jianguo Zhou, Muqddas Tariq, Carl Ward, Guoliang Xu, Yayan Feng, Yinghua Huang, Guangming Wu, Dongye Wang, Isaac A. Babarinde, Karthik Arumugam, Runsheng Chen, Meng Zhang, Maria Pia Cosma
Publikováno v:
Zhang, M, Lai, Y, Krupalnik, V, Guo, P, Guo, X, Zhou, J, Xu, Y, Yu, Z, Liu, L, Jiang, A, Li, W, Abdul, M M, Ma, G, Li, N, Fu, X, Lv, Y, Jiang, M, Tariq, M, Kanwal, S, Liu, H, Xu, X, Zhang, H, Huang, Y, Wang, L, Chen, S, Babarinde, I A, Luo, Z, Wang, D, Zhou, T, Ward, C, He, M, Ibañez, D P, Li, Y, Zhou, J, Yuan, J, Feng, Y, Arumugam, K, Di Vicino, U, Bao, X, Wu, G, Schambach, A, Wang, H, Sun, H, Gao, F, Qin, B, Hutchins, A P, Doble, B W, Hartmann, C, Cosma, M P, Qin, Y, Xu, G L, Chen, R, Volpe, G, Chen, L, Hanna, J H & Esteban, M A 2020, ' β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus ', Science Advances, vol. 6, no. 29, eaba1593 . https://doi.org/10.1126/sciadv.aba1593
Science Advances
Science Advances
β-Catenin recruits BRD4 and other coregulators to protect pluripotency gene transcription against network perturbation.
Mouse embryonic stem cells cultured with MEK (mitogen-activated protein kinase kinase) and GSK3 (glycogen synthase kinase 3)
Mouse embryonic stem cells cultured with MEK (mitogen-activated protein kinase kinase) and GSK3 (glycogen synthase kinase 3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa95a363690f8a96363da35725175e5
https://curis.ku.dk/portal/da/publications/catenin-safeguards-the-ground-state-of-mouse-pluripotency-by-strengthening-the-robustness-of-the-transcriptional-apparatus(ea0c514e-4c4e-4222-bfe1-e57f1504a1b4).html
https://curis.ku.dk/portal/da/publications/catenin-safeguards-the-ground-state-of-mouse-pluripotency-by-strengthening-the-robustness-of-the-transcriptional-apparatus(ea0c514e-4c4e-4222-bfe1-e57f1504a1b4).html
Autor:
Synnøve Brandt Ræder, Kirsten Skarstad, Aina Nedal, Emily Helgesen, Magnar Bjørås, Balagra Kasim Sumabe, Jacob H. Martinsen, Bjørn Dalhus, Birthe B. Kragelund, Marit Otterlei, Kim Lindland, Rune Johansen Forstrøm
Publikováno v:
Nucleic Acids Research
Nedal, A, Ræder, S B, Dalhus, B, Helgesen, E, Forstrøm, R J, Lindland, K, Sumabe, B K, Martinsen, J H, Kragelund, B B, Skarstad, K, Bjørås, M & Otterlei, M 2020, ' Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis ', Nucleic Acids Research, vol. 48, no. 10, pp. 5540-5554 . https://doi.org/10.1093/nar/gkaa278
Nedal, A, Ræder, S B, Dalhus, B, Helgesen, E, Forstrøm, R J, Lindland, K, Sumabe, B K, Martinsen, J H, Kragelund, B B, Skarstad, K, Bjørås, M & Otterlei, M 2020, ' Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis ', Nucleic Acids Research, vol. 48, no. 10, pp. 5540-5554 . https://doi.org/10.1093/nar/gkaa278
In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, share a C-terminal hydrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1166f160e0f70964f9dd1e874599634
https://hdl.handle.net/11250/2679696
https://hdl.handle.net/11250/2679696
Autor:
Thomas W. Lyons, Jacob H. Waldman, Yanke Xu, David A. Thaisrivongs, William J. Morris, Varsolona Richard J, Laura Artino, Andrew Brunskill
Publikováno v:
Organic Process Research & Development. 22:385-390
Verubecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) that is currently under clinical evaluation for the treatment of prodromal Alzheimer’s disease. This article describes the characterization of a co-crysta
Autor:
H. Diessel Duan, Paul W. King, Lance C. Seefeldt, Mary H. Plunkett, Anne-Frances Miller, Monika Tokmina-Lukaszewska, John W. Peters, John P. Hoben, Timothy S. Magnuson, Rhesa N. Ledbetter, Brett M. Barney, David W. Mulder, Jacob H. Artz, Carolyn E. Lubner, Jacquelyn Miller, Amaya M. Garcia Costas, Angela Patterson, Zackary J. Jay, Brian Bothner, Ross P. Carlson
Publikováno v:
Biochemistry
The biological reduction of dinitrogen (N(2)) to ammonia (NH(3)) by nitrogenase is an energetically demanding reaction that requires low-potential electrons and ATP; however, pathways used to deliver the electrons from central metabolism to the reduc