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Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 37:871-881
Background: Colorectal cancer (CRC) is the third most common malignancy worldwide. Matrine can act as a potential antitumor drug, and its antitumor activities have been tested in various cancers, including CRC. However, the effect of matrine and the
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 37:815-823
Background: Endometrial cancer (EC) is an intractable gynecological cancer with increasing incidence and mortality worldwide. Accumulating studies indicated that long noncoding RNA nuclear enriched...
Publikováno v:
Medicinal Chemistry. 18:710-723
Background: Cancer therapy is one of the most important challenges that human beings are facing. The abnormal activity of epidermal growth factor receptor tyrosine kinase (EGFR1) in tumors has been reported in many studies. Tyrosine kinase inhibitors
Autor:
Komal Ruikar, Satish G. Patil, Vishwas Kaveeshwar, Anil Bargale, Sumangala Patil, Vitthal Khode, E. Sarathkumar
Publikováno v:
Current Molecular Medicine. 22:449-457
Background: Triple Negative Breast Cancer (TNBC) commonly displays Epidermal growth factor receptor (EGFR). Effective EGFR degradation results in the suppression of tumor in various models. Studies have addressed the relevance of this strategy in the
Publikováno v:
Current Medicinal Chemistry. 29:3748-3773
Although significant progress over several decades has been evidenced in cancer therapy, there remains a need for the development of novel and effective therapeutic strategies to treat several relapsed and intractable cancers. In this regard, tubulin
Publikováno v:
Current Molecular Medicine. 22:442-448
Objective: Psoriasis is a chronic inflammatory skin disease highly depending on angiogenesis. Our prior results showed that the mRNA and protein of Del-1 in dermal mesenchymal stem cells (dMSCs) was up-regulated from psoriasis. Our aim was further to
Autor:
Mehdi Asadi, Elnaz Rezaeiamiri, Mohsen Amini, Massoud Amanlou, Saeed Bahadorikhalili, Mohammad Nazari Montazer, Zahra Rezaei
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:2011-2025
Background and Objective: Tubulin inhibitors have proved to be a promising treatment against cancer. Tubulin inhibitors target different areas in microtubule structure to exert their effects. The colchicine binding site (CBS) is one of them for which
Autor:
Salundi Basappa, Gautam Sethi, Chakrabhavi Dhananjaya Mohan, Vijai Kumar Gupta, Habbanakuppe D. Preetham, Shobith Rangappa, S. Chandra Nayaka, Kanchugarakoppal S. Rangappa
Publikováno v:
Seminars in Cancer Biology. 80:157-182
Signal transducer and activator of transcription (STAT) proteins are latent transcription factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon stimulation by cytokines and growth factors, STATs get activated an
Autor:
Yuehua Li, Ting Gao, Fuqiang Gong, Liming Xie, Xiaoping Wu, Baohong Jiang, Liting Tang, Yu Zhou, Hongbo Zhu, Yeru Tan
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1723-1734
Background: Cancer stem cells could influence tumor recurrence and metastasis. Objective: To develop a new effective treatment modality targeting breast cancer stem cells (BCSCs) and to explore the role of Apatinib in BCSCs. Methods: BCSCs were isola
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 37:246-255
Background: Pituitary adenoma (PA) is a kind of common primary brain tumor with invasive properties. Although the fact that long noncoding RNA (lncRNA) small nucleolar RNA host gene 6 (SNHG6) exerts oncogenic function in cancer cells and that miR-944