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Autor:
Zhang Hai, Jiao Wu, Yu-Meng Zhu, Jie-Jie Geng, Ping Zhu, Qi-Jing Li, Zhi-Nan Chen, Ruo Chen, Peng Lin, Ke Wang, Fengfan Yang, Xianghui Fu, Zhuan Feng
Publikováno v:
Cellular and Molecular Immunology
Regulatory T cell (Treg) stability is necessary for the proper control of immune activity and tissue homeostasis. However, it remains unclear whether Treg stability must be continually reinforced or is established during development under physiologic
Autor:
Rosa Maria Borzì, Annalisa Astolfi, Stefania D'Adamo, Spartaco Santi, Eleonora Olivotto, Mariagrazia Uguccioni, Manuela Minguzzi, Kenneth B. Marcu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
IKKα and IKKβ are essential kinases for activating NF-κB transcription factors that regulate cellular differentiation and inflammation. By virtue of their small size, chemokines support the crosstalk between cartilage and other joint compartments
Autor:
Richard T. D'Aquila, Gaël K. Scholtés, Aubrey M. Sawyer, Cristina C. Vaca, Meejeon Roh, Isabelle Clerc, Chisu Song
Publikováno v:
Transl Res
The seven members of the A3 family of cytidine deaminases (A3A to A3H) share a conserved catalytic activity that converts cytidines in single-stranded (ss) DNA into uridines, thereby inducing mutations. After their initial identification as cell-intr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Cilia are microtubule-based hair-like organelles propelling locomotion and extracellular liquid flow or sensing environmental stimuli. As cilia are diffusion barrier-gated subcellular compartments, their protein components are thought to come from th
Autor:
Hongyan Wang, Robert G. Roeder, Zhong Chen, Yue Zhao, William Hankey, Alexandre Rosa Campos, Jiaoti Huang, Qianben Wang, Jeff Groth, Furong Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
RNA Polymerase II (Pol II) transcriptional recycling is a mechanism for which the required factors and contributions to overall gene expression levels are poorly understood. We describe an in vitro methodology facilitating unbiased identification of
Publikováno v:
Journal of Cellular and Molecular Medicine
Immunotherapy has been identified a promising treatment of cancers, including Oral squamous cell carcinoma (OSCC). CRNDE is highly overexpressed in various cancers. Many lncRNAs have been reported in CD8 T lymphocytes. Little is investigated about th
Autor:
Amit Kunwar, Vishwa V Gandhi, Jayant Sastri Goda, Vikram Gota, Liladhar B. Kumbhare, K.A. Gandhi, K.I. Priyadarsini
Publikováno v:
Free Radical Biology and Medicine. 175:1-17
The aim of present study was to investigate the anticancer mechanisms of 3,3′-diselenodipropionic acid (DSePA), a redox-active organodiselenide in human lung cancer cells. DSePA elicited a significant concentration and time-dependent cytotoxicity i
Autor:
Xiaofeng Zou, Quanliang Liu, Guancheng Xiao, Kaiyang Qiu, Yuting Wu, Junrong Zou, Guoxi Zhang, Gengqing Wu, Rihai Xiao, Hui Xu, Biao Qian, Yunfeng Liao, Yanmin Li, Tianpeng Xie, Jinglin Shi, Zhihua He, Yuanhu Yuan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinom
Autor:
Carolyn K. J. Young, Md. Mostafijur Rahman, Hyacintha-ghislaine M. Bisimwa, Elena J. Ciesielska, Marcos T. Oliveira, Grzegorz L. Ciesielski, Shalom Kim, Matthew J. Young, Cody Grier
Publikováno v:
Mitochondrion
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2022-04-29T08:35:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01 The COVID-19 pandemic prompted the FDA to authorize a new nucleoside analogue, remdesivir, for emergency use in affected individuals. We exam
Autor:
Beatrix Bradford, Chunyuan Jin
Publikováno v:
Semin Cancer Biol
Pre-mRNA processing of the replication-dependent canonical histone mRNAs requires an endonucleolytic cleavage immediately after a conserved stem loop structure which occurs before RNA Pol II encounters any poly(A) signal. Thus, in contrast to all oth