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Autor:
Won-Ki Kim, Yeonsoo Joe, Jeongmin Park, Young-Joon Surh, Su-Jung Kim, Hun Taeg Chung, Seung Hyeon Kim, Hye-Kyung Na, Ishrat Aklima Muna, Ha-Na Lee, Shin-Young Gwak
Publikováno v:
Gut and Liver. 16:246-258
Background/aims Heme oxygenase-1 (HO-1) plays a central role in cellular defense against inflammatory insults, and its induction in macrophages potentiates their efferocytic activity. In this study, we explored the potential role of macrophage HO-1 i
Autor:
Jian-Feng Liu, You Jin, Jian-Guo Chen, Lan Ni, Zhuang-Li Hu, Cong Ma, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Hui-Ling Zheng, Fang Wang, Wen-Long Xie, Hou-Hong Li
Publikováno v:
Biological Psychiatry. 91:593-603
Background Depression is a common psychiatric disorder associated with the defects in GABAergic neurotransmission. α-Dystroglycan (α-DG), a cell adhesion molecule known to be essential for skeletal muscle integrity, is also present at inhibitory sy
Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy
Autor:
Simon F. Lacey, Stephen J. Schuster, Elise A. Chong, Sunita D. Nasta, Jakub Svoboda, Marco Ruella, Siddharth Bhattacharyya, E. John Wherry, Cécile Alanio, Daniel J. Landsburg
Publikováno v:
Blood
CD19-directed chimeric antigen receptor–modified (CAR T) T cells achieve durable remissions in about 30% to 40% of relapsed/refractory large B-cell lymphomas. T-cell exhaustion and/or an immunosuppressive tumor microenvironment may contribute to CA
Autor:
Jiarui Wang, Xianqin Zhang, Tingting Zou, Dazhi Zhang, Wenqiang Liu, Zhenxing Liu, Xuejie Peng, Zhengyi Ni, Yang Tan, Meiqi Hou, Mi Zhou, Chao Yuan, Xiaopei Zhou
Publikováno v:
Biochemical and Biophysical Research Communications. 591:124-129
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare monogenetic disease, which is characterized by susceptibility to some weakly virulent mycobacteria. Here, we explored the pathogenic genes and molecular mechanisms of MSMD patients. W
Publikováno v:
Am J Respir Cell Mol Biol
Airway smooth muscle thickening, a key characteristic of chronic asthma, is largely attributed to increased smooth muscle cell proliferation and reduced smooth muscle apoptosis. Polo-like kinase 1 (Plk1) is a serine/threonine protein kinase that part
Publikováno v:
Cancer letters, Vol. 524 (2021) pp. 1-14
Glucose-related protein 78 (GRP78) is a chaperone protein localized primarily in the endoplasmic reticulum (ER) lumen, where it helps in proper protein folding by targeting misfolded proteins and facilitating protein assembly. In stressed cells, GRP7
Autor:
William H. Walker
Publikováno v:
Semin Cell Dev Biol
Male fertility requires the continual production of sperm by the process of spermatogenesis. This process requires the correct timing of regulatory signals to germ cells during each phase of their development. MicroRNAs (miRNAs) in germ cells and sup
Publikováno v:
Seminars in Cell & Developmental Biology. 121:10-23
Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytoto
Publikováno v:
Seminars in Cell & Developmental Biology. 121:63-70
Stem cells are specialized cells that can renew themselves through cell division and can differentiate into multi-lineage cells. Mesenchymal stem cells are adult stem cells that exist in animal and human tissues. Mesenchymal stem cells have the abili
Autor:
Sheng Gao, Lingling Wang, Fei Sun, C. Yan Cheng, Liwei Zhou, Tiao Bu, Siwen Wu, Xiaolong Wu, Jie Shi, Di Wu
Publikováno v:
Seminars in Cell & Developmental Biology. 121:125-132
Studies have demonstrated that biologically active fragments are generated from the basement membrane and the Sertoli cell-spermatid adhesion site known as apical ectoplasmic specialization (apical ES, a testis-specific actin-based anchoring junction