Zobrazeno 61 - 70
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Autor:
Yu Ting Huang, Hui Chi Tang, Wei Yi Chen, Ping Hui Tseng, Guo Cheng Huang, Kou Juey Wu, Greg G. Wang, Ta Hsien Lin, An Chieh Cheng, Ling Cai
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
USP7, one of the most abundant ubiquitin-specific proteases (USP), plays multifaceted roles in many cellular events, including oncogenic pathways. Accumulated studies have suggested that USP7, through modulating the MDM2/MDMX-p53 pathway, is a promis
Autor:
Aurelie Pac-Soo, Lin Chen, Daqing Ma, Hailin Zhao, Qian Chen, Shanglong Yao, You Shang, Azeem Alam
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Epithelial–mesenchymal transition (EMT) plays a crucial role in the development of pulmonary fibrosis. This study aims to investigate the effects of valproic acid (VPA) on EMT in vitro and in vivo. In vitro, EMT was induced by the administration of
Autor:
Ravi C. Kalathur, SangJoon Lee, Thirumala-Devi Kanneganti, Lam Nhat Nguyen, Rajendra Karki, Yaqiu Wang
Publikováno v:
Nature. 597:415-419
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and inducing cell death in infected cells1. There are several inflammasome sensors that each detect and respond to a specific pathogen- or damage-associated molecular p
Autor:
Xiao Qian Chen, Shang Bin Yu, Song Lin Yin, Guo Qiang Liu, Feng Hu, Feng Liu, Chun Yang Li, Xiao Hong Xu, Ting Ting Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 569:1-9
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor without curable therapy. Surgical resection remains the first choice of patients with GBM but tumors relapse rapidly even combined with conventional chemoradiotherapy. The
Autor:
Anniefer N. Magpusao, Xiaoyan Sun, Di Hu, Drew J. Adams, Kathleen C. Lundberg, Benlian Wang, Xin Qi, Matthew A. Thompson, Yuriy Fedorov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Mitochondrial dysfunction is a common hallmark of neurological disorders, and reducing mitochondrial damage is considered a promising neuroprotective therapeutic strategy. Here, we used high-throughput small molecule screening to identify CHIR99021 a
Autor:
Partha Chakrabarti, Piyali Majumder, Kaushik Chanda, Nihar Ranjan Jana, Debajyoti Das, Brijesh Kumar Singh, Debashis Mukhopadhyay
Publikováno v:
Biochemical Journal
Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) share a common hallmark of insulin resistance. Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK and RYK, both targets of the same micro RNA miR-1271, exhibit significant and consis
Autor:
Shuyue Sheng, Yanlin Yang, Shijing Ren, Yaoming Xue, Xiangyu Wang, Meiping Guan, Meina Zou, Ling Wang
Publikováno v:
In Vitro Cellular & Developmental Biology. Animal
Diabetic kidney disease (DKD) has become the most common cause of chronic kidney disease. Proteinuria is generally considered one of the clinical indicators of renal damage, and it is also closely related to the progression of DKD. Accumulating evide
Autor:
Judith A. Voynow, Apparao B. Kummarapurugu, Shuo Zheng, Adam M. Hawkridge, Shobha Ghosh, Jonathan Ma
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 321:L555-L565
Patients with cystic fibrosis (CF) have defective macrophage phagocytosis and efferocytosis. Several reports demonstrate that neutrophil elastase (NE), a major inflammatory protease in the CF airway, impairs macrophage phagocytic function. To date, N
CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII
Autor:
Jyoti Rana, Sandeep R. P. Kumar, Todd M. Brusko, Rania Saboungi, Moanaro Biswas, Maite Muñoz-Melero, Daniel J. Perry
Publikováno v:
Molecular Therapy. 29:2660-2676
Regulatory T cells (Tregs) control immune responses in autoimmune disease, transplantation, and enable antigen-specific tolerance induction in protein-replacement therapies. Tregs can exert a broad array of suppressive functions through their T cell
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:1428-1439
Bone marrow mesenchymal stromal cells (BMMSCs) are widely sourced and easily amplified in vitro; thus, they have a great potential in the treatment of hemopathies. Recent findings suggested that BMMSCs express the aryl hydrocarbon receptor (AHR). How