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Autor:
Yang Du, Tianhao Duan, Chumeng Cheng, Bingnan Yin, Xin Liu, Helen Yicheng Wang, Chen Qian, Rong Fu Wang, Jill Henley, Changsheng Xing, Siyao Liu, Pengfei Zhang, Junjun Chu
Publikováno v:
Nature Metabolism
Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is a virus-induced inflammatory disease of the airways and lungs that leads to severe multi-organ damage and death. Here we show that cellular lipid synthesis is require
Autor:
Wilson I. Gonsalves, Larry M. Karnitz, Sadae Hitosugi, Kiran Kurmi, Taro Hitosugi, Annapoorna Sreedhar, Elizabeth K. Wiese, Yuan-Ping Pang, Lindsey G. Andres-Beck, Sharon T. Loa
Publikováno v:
Nature metabolism
Pharmacological activation of the glycolytic enzyme PKM2 or expression of the constitutively active PKM1 isoform in cancer cells results in decreased lactate production, a phenomenon known as the PKM2 paradox in the Warburg effect. Here we show that
Autor:
Xiaodong Lv, Zitong Zha, Jie Tang, Bicheng Hu, Xin Li, Jerry L. Workman, Xilan Yu, Jianguo Chen, Wanping Chen, Lixin Ma, Yinsheng Wu, Qi Yu, Shanshan Li
Publikováno v:
Nature Metabolism. 3:983-1000
Acetyl-CoA is a central node in carbon metabolism and plays critical roles in regulatory and biosynthetic processes. The acetyl-CoA synthetase Acs2, which catalyses acetyl-CoA production from acetate, is an integral subunit of the serine-responsive S
Autor:
Joshua W. Goyert, Ho-Joon Lee, Sumeet Solanki, Matthew G. Vander Heiden, Samuel A. Kerk, Brian T. Do, Costas A. Lyssiotis, Yatrik M. Shah, Brandon Chen, Jason R. Spence, Michael K. Dame, Cristina Castillo, Xiang Xue, Peggy P. Hsu, Andrew J. Schwartz, Samira Lakhal-Littleton, Rashi Singhal
Publikováno v:
Nature metabolism
Colorectal cancer (CRC) requires massive iron stores, but the complete mechanisms by which CRC modulates local iron handling and metabolically leverages iron are poorly understood. We demonstrate that the liver-derived, endocrine regulator of systemi
Autor:
Daniel H. Katz, Robert E. Gerszten, Lori L. Jennings, Changyu Shen, Theresa Margarethe Rienmüller, Christian Baumgartner, Claude Bouchard, Mark A. Sarzynski, Jacob L. Barber, Pierre M. Jean Beltran, Michelle J. Keyes, Daniela Schranner, Sujoy Ghosh, Robert Ross, Bennet Peterson, Usman A. Tahir, Jeremy M. Robbins, Shuliang Deng, Steven A. Carr
Publikováno v:
Nat Metab
Maximal oxygen uptake (VO2max) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VO2max, and of increases of VO2max in resp
Publikováno v:
Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 12, Iss 10, Pp 1765-1774 (2021)
Journal of Diabetes Investigation, Vol 12, Iss 10, Pp 1765-1774 (2021)
Aims/Introduction Peroxisome proliferator‐activated receptor (PPAR)‐γ2 is a transcription factor crucial for regulating adipogenesis and glucose/lipid metabolism, and synthetic PPARγ ligands, such as thiazolidinediones, are effective oral medic
Publikováno v:
Pancreas. 50:756-765
Objectives This study aimed to investigate the effect and mechanism of hypoxia on pancreatic cancer (PC) cell dedifferentiation and tumorigenic potential. Methods Inhibition of hypoxia-inducible factor 1α (HIF-1α) and overexpression of Notch1 in PC
Autor:
Anushka Gupta, Tian Lian Huang, Yu-Hua Tseng, Farnaz Shamsi, Matthew D. Lynes, Mary E. Piper, Aaron M. Streets, Li-Lun Ho
Publikováno v:
Nature metabolism
Brown adipose tissue (BAT) and beige fat function in energy expenditure in part due to their role in thermoregulation, making these tissues attractive targets for treating obesity and metabolic disorders. While prolonged cold exposure promotes de nov
Autor:
Nicolas Skuli, M. Celeste Simon, Romain Riscal, Itzhak Nissim, Jun Song, Jason Godfrey, Hong Xie
Publikováno v:
Nature metabolism
Glycogen accumulation is a highly consistent, distinguishable characteristic of clear cell renal cell carcinoma (ccRCC)1. While elevated glycogen pools might be advantageous for ccRCC cells in nutrient-deprived microenvironments to sustain tumour via
Publikováno v:
Diabetologia
Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over the past 50 years, elucidation of the insulin signalling network has provided important mechanistic insights into the abnormalities of glucose, lipid and p