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Publikováno v:
Laboratory Investigation. 102:411-421
Acute lymphoblastic leukemia (ALL) is a common malignancy in children. In this study, we aimed to explore putative mechanisms of microRNA-155-5p (miR-155-5p) involvement in childhood ALL (cALL) via interactions with casitas B-lineage lymphoma (CBL),
Publikováno v:
Clinical Hemorheology and Microcirculation. 80:167-183
Atherosclerosis is a major cause of cardiovascular disease, in which vascular smooth muscle cells (VSMCs) proliferation and migration play a vital role. Circular RNAs (circRNAs) have been reported to be correlated with the VSMCs function. Therefore,
Publikováno v:
Am J Respir Cell Mol Biol
Airway smooth muscle thickening, a key characteristic of chronic asthma, is largely attributed to increased smooth muscle cell proliferation and reduced smooth muscle apoptosis. Polo-like kinase 1 (Plk1) is a serine/threonine protein kinase that part
Autor:
Paul M. Daniel, Frédéric Hollande, Andrew P. Morokoff, Gulay Filiz, Sebastian Dworkin, Theo Mantamadiotis, Daniel Brown, Wayne Ng, Nicole Kountouri, Stephanie Amiridis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently to ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93541fc9763c8c99c234f613764a359
Autor:
Ting-An Chou, Yi-Fang Huang, Chung-Yi Nien, Hsiang-Hsi Hong, Chao-Hua Liang, Adrienne Hong, Hui-Yi Hsiao, Tzung-Hai Yen, Alex Hong
Publikováno v:
Journal of Periodontology. 93:1553-1565
BACKGROUNDS Alveolar bone and cementum share many biological and developmental similarities. The mineralizing effect of calcitriol has been previously reported. Yet, its cementoinductivity has not been confirmed. This study evaluated the potential ce
Publikováno v:
Bioengineered, Vol 13, Iss 1, Pp 164-177 (2022)
Bioengineered
article-version (VoR) Version of Record
Bioengineered
article-version (VoR) Version of Record
Angiogenesis plays an important role in tissue development and repair, and how to regulate angiogenesis effectively is a widely studied problem in the biomedical field. In recent years, the role of autophagy in vascular endothelial cells has attracte
Publikováno v:
Biochemical and Biophysical Research Communications. 587:9-15
Objective The role of circadian clock in cementogenesis is unclear. This study examines the role of REV-ERBs, one of circadian clock proteins, in proliferation, migration and mineralization of cementoblasts to fill the gap in knowledge. Methods Expre
Publikováno v:
Blood. 138:2244-2255
Internal tandem duplication within FLT3 (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and correlates with a poor prognosis. Whereas the FLT3 receptor tyrosine kinase is activated at the plasma membrane to transduce
Publikováno v:
DNA and Cell Biology
D-type cyclins (cyclin D1, D2, and D3, together cyclin D) are central drivers of the cell division cycle and well-described proto-oncoproteins. Rapid turnover of cyclin D is critical for its regulation, but the underlying mechanism has remained a mat
Publikováno v:
Bioengineered, Vol 12, Iss 2, Pp 9463-9472 (2021)
Bioengineered
article-version (VoR) Version of Record
Bioengineered
article-version (VoR) Version of Record
Vascular smooth muscle cell (VSMC) hyperplasia is closely associated with AS progression. Hence, it is of great significance to elucidate the molecular mechanisms underlying the involvement of VSMCs in AS. SHH antagonist can inhibit the excessive pro