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Autor:
Paul M. Daniel, Frédéric Hollande, Andrew P. Morokoff, Gulay Filiz, Sebastian Dworkin, Theo Mantamadiotis, Daniel Brown, Wayne Ng, Nicole Kountouri, Stephanie Amiridis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently to ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93541fc9763c8c99c234f613764a359
Autor:
Chunyan Hu, Lan Hong, Kang Wang, Kaiying Cui, Chunbo Hao, Sheng-tan Wang, Zaihong Li, Gen-hai Zhu
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-17 (2021)
Journal of Ovarian Research
Journal of Ovarian Research
Background Circular RNAs (circRNAs) are increasingly recognized as important regulators in cancer including ovarian cancer (OC). This work focuses on the effects of circ_0000745 on the OC development of and molecules involved. Methods Expression of c
Autor:
Hyun-Il Cho, Yunkyung Lee, Tai-Gyu Kim, Gaeun Hur, Hee-Je Kim, Haeyoun Choi, Sang-Eun Lee, Hyun-Jung Sohn, Byung Sik Cho
Publikováno v:
Cytotherapy. 23:908-917
Background aims Immunotherapeutic approaches using γδ T cells have emerged as the function of γδ T cells in tumor surveillance and clearance has been discovered. In vitro expansion methods of γ9δ2 T cells have been based on phosphoantigens and
Publikováno v:
Cancer Letters. 514:30-37
Recently, many studies have shown that deubiquitination modification of proteins is of great significance in major physiological processes such as cell proliferation, apoptosis, and differentiation. The ubiquitin-specific peptidase (USP) family is on
Autor:
Yu Liu, Di Chen, Hong-Xu Liu, Wuxiyar Otkur, Huan Qi, Hai-long Piao, Yawei Wang, Tian Xia, Yong Zhang, Chao Duan, Xiaolong Liu, Huan Chen
Publikováno v:
Cancer Science
It is widely accepted that redox reprogramming participates in malignant transformation of lung adenocarcinoma (LUAD). However, the source of excessive reactive oxygen species (ROS) and the downstream signaling regulatory mechanism are complicated an
Autor:
Shunsuke Hanaki, Takahiro Masaki, Yuki Sato, Makoto Nakanishi, Midori Shimada, Keisuke Maeda, Makoto Habara
Publikováno v:
Cancer Science
DNA damage induces transcriptional repression of E2F1 target genes and a reduction in histone H3‐Thr11 phosphorylation (H3‐pThr11) at E2F1 target gene promoters. Dephosphorylation of H3‐pThr11 is partly mediated by Chk1 kinase and protein phosp
Autor:
Amanda R. Haltom, Ajay Sharma, Vidya Gopalakrishnan, Shinji Maegawa, Lin Xu, Jyothishmathi Swaminathan, Tara Dobson, Xue Xiao, Vikas Kundra, Xiao-Nan Li, Yanwen Yang, Shavali Shaik, Arif Harmanci, Keri Schadler, Feng Wang
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1486-1506 (2021)
Molecular Oncology
Molecular Oncology
Expression of the RE1‐silencing transcription factor (REST), a master regulator of neurogenesis, is elevated in medulloblastoma (MB) tumors. A cell‐intrinsic function for REST in MB tumorigenesis is known. However, a role for REST in the regulati
Autor:
Bowen Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Yangyang Yang, Huijian Wu, Shujing Li, Binggong Zhao, Yanan Li, Bashir Ahmad
Publikováno v:
Cancer Letters. 502:108-119
The underlying mechanism of orphan nuclear receptor estrogen-related receptor α (ERRα) in breast cancer was investigated by identifying its interaction partners using mass spectrometry. F-box and leucine-rich repeat protein 10 (FBXL10), which modul
Publikováno v:
Cancer Science
Lung adenocarcinoma (LAC) is the most prevalent form of lung cancer. Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor that has been implicated in oncogenic and malignant phenotypes of LAC. Here, we identified an
Autor:
Caitrin Crudden, Julianna Serly, Ada Girnita, Daniela Nedelcu, George A. Calin, Dawei Song, Sonia Cismas, Takashi Shibano, Enrique Fuentes-Mattei, Mihnea P. Dragomir, Andrei Adrian Tica, Leonard Girnita
Publikováno v:
Cancer Research, 81(2), 501-515. American Association for Cancer Research Inc.
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G protein-coupled receptor kinase 2 promotes unbiased downregulation of IGF-1 receptor and restrains malignant cell growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G protein-coupled receptor kinase 2 promotes unbiased downregulation of IGF-1 receptor and restrains malignant cell growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
The ability of a receptor to preferentially activate only a subset of available downstream signal cascades is termed biased signaling. Although comprehensively recognized for the G protein–coupled receptors (GPCR), this process is scarcely explored