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Publikováno v:
Laboratory Investigation. 102:411-421
Acute lymphoblastic leukemia (ALL) is a common malignancy in children. In this study, we aimed to explore putative mechanisms of microRNA-155-5p (miR-155-5p) involvement in childhood ALL (cALL) via interactions with casitas B-lineage lymphoma (CBL),
Autor:
Joseph S. Durgin, Zev A. Binder, Vijay Bhoj, Michael C. Milone, Donald M. O'Rourke, Radhika Thokala, Saba Ghassemi, Roddy S. O’Connor, Lexus R. Johnson, John Leferovich, Edward Z Song
Publikováno v:
Molecular Therapy. 30:1201-1214
Prior to adoptive transfer, CAR T cells are activated, lentivirally infected with CAR transgenes, and expanded over 9 to 11 days. An unintended consequence of this process is the progressive differentiation of CAR T cells over time in culture. Differ
Autor:
Alain Fournier, Marielle Chiron, Nadège Carrié, Sukhvinder Sidhu, Marine Cuisinier, Sahar Kassem, Dmitri Wiederschain, Hélène Bonnevaux, Jean-Luc Teillaud, Ludovic Martinet, Helgi van de Velde, Jill Corre, Isabelle Arnould, Béré K. Diallo, Nizar El-Murr, Céline Nicolazzi, Angela Virone-Oddos, Hervé Avet-Loiseau, Alexandre Tang
Publikováno v:
Blood. 139:1160-1176
Anti-CD38 monoclonal antibodies (mAbs) represent a breakthrough in the treatment of multiple myeloma (MM), yet some patients fail to respond or progress quickly with this therapy, highlighting the need for novel approaches. In this study we compared
Autor:
Hiroshi Imanaga, Tatsuya Terasaki, Koichi Akashi, Kensuke Sasaki, Fumihiko Nakao, Takeshi Inukai, Jumpei Nogami, Takahiro Maeda, Els Verhoeyen, Takuji Yamauchi, Koshi Akahane, Yuichiro Semba
Publikováno v:
Blood
Acute lymphoblastic leukemia (ALL) harboring the IgH-CRLF2 rearrangement (IgH-CRLF2-r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). While multiple chemother
Autor:
Myrianni Constantinou, Silvia Marino, Sebastian Brandner, Tedani El-Hassan, James Innes, Natasha Aley, Ayad Eddaoudi, Raquel Fonseca, Joanne Lau, Andrew S. Lowe
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
The phenotype of glioma-initiating cells (GIC) is modulated by cell-intrinsic and cell-extrinsic factors. Phenotypic heterogeneity and plasticity of GIC is an important limitation to therapeutic approaches targeting cancer stem cells. Plasticity also
Publikováno v:
International Journal of Biological Sciences
Simultaneous P53 loss and activation of the PTEN-restricted PI3K-AKT pathway frequently occur in aggressive breast cancers. P53 loss causes genome instability, while PTEN loss and/or activating mutations of PIK3CA and AKT promote cancer cell prolifer
Publikováno v:
World Neurosurgery. 157:e390-e400
Objective To assess effect of licochalcone A (LicA) on amyloid-β (Aβ) peptide fragment 25–35–induced nerve injury and reveal the potential molecular mechanisms involved. Methods Viability of SH-SY5Y cells was measured by 3-(4,5-dimethylthiazol-
Autor:
Beat Bornhauser, Roland P. Kuiper, Steven M. Kornblau, Britt M.T. Vervoort, Jiangyan Yu, Rico Hagelaar, Fieke W Hoff, Frank N. van Leeuwen, Dorette van Ingen Schenau, Maria Pamela Dobay, Trisha M Tee, Laurens T. van der Meer, Silvia Jenni, Jules P.P. Meijerink, Jean-Pierre Bourquin, Miriam Butler
Publikováno v:
Blood, 138(23), 2383-2395. AMER SOC HEMATOLOGY
Blood, 138, 23, pp. 2383-2395
Blood, 138, 2383-2395
Blood, 138, 23, pp. 2383-2395
Blood, 138, 2383-2395
Contains fulltext : 241347.pdf (Publisher’s version ) (Closed access) Asparaginase (ASNase) therapy has been a mainstay of acute lymphoblastic leukemia (ALL) protocols for decades and shows promise in the treatment of a variety of other cancers. To
Autor:
Li Wang, Yudao Shen, Jian Jin, Jia Xu, Kaitlyn M. Cahuzac, Xian Chen, Xufen Yu, Ramon Parsons, Jing Liu, Ling Xie
Publikováno v:
J Med Chem
The serine/threonine kinase AKT functions as a critical node of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (m-TOR) signaling pathway. Aberrant activation and overexpression of AKT are strongly correlated with numerous
Publikováno v:
Blood. 138:2244-2255
Internal tandem duplication within FLT3 (FLT3-ITD) is one of the most frequent mutations in acute myeloid leukemia (AML) and correlates with a poor prognosis. Whereas the FLT3 receptor tyrosine kinase is activated at the plasma membrane to transduce