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Autor:
Yun Ke, Peiyi Xie, Bidong Fu, Yongqi Ding, Jing Zhen, Yue Liu, Qing Chao, Jing Xie, Jiayu Fang, Da Huang, Jiuang Mao
Publikováno v:
Journal of Cellular and Molecular Medicine
Deubiquitinating enzyme OTU domain‐containing ubiquitin aldehyde‐binding proteins 1 (OTUB1) has been shown to have an essential role in multiple carcinomas. However, the function of OTUB1 in papillary thyroid cancer (PTC) and the underlying mecha
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is s
Publikováno v:
Journal of Cellular and Molecular Medicine
The cell division cycle associated 8 (CDCA8) is a crucial component of the chromosome passenger complex (CPC). It has been implicated in the regulation of cell dynamic localization during mitosis. However, its role in hepatocellular carcinoma (HCC) i
Autor:
Zhan-Li Chen, Jin-Yu Liu, Ya-Jing Chen, Yun-Long Wang, Shi-Mei Zhuang, Huan-Hui Feng, Jine Yang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Oncogenic c-Myc is a master regulator of G1/S transition. Long non-coding RNAs (lncRNAs) emerge as new regulators of various cell activities. Here, we found that lncRNA SnoRNA Host Gene 17 (SNHG17) was elevated at the early G1-phase of cell cycle. Bo
Publikováno v:
Journal of Cellular and Molecular Medicine
Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death worldwide. Its high metastasis rate is significantly correlated with poor patient prognosis. Elucidating the molecular mechanism underlying HCC metastasis is essential for HC
Autor:
Arisa Kase, Yuichiro Kanno, Ryoichi Kizu, Kiyomitsu Nemoto, Moeno Ozawa, Naoya Yamashita, Chiharu Taga, Arika Yoshizuka, Noriko Sanada
Publikováno v:
Biochemical and Biophysical Research Communications. 570:131-136
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates various toxicological and biological functions. We reported previously that 3-methylcholanthrene (3MC), an exogenous AhR agonist, inhibited tumorsphere (mam
Publikováno v:
Cell Biology International. 45:2420-2428
Multidrug resistance (MDR) is the main cause of chemotherapy failure in the treatment of colon cancer and the high expression of drug efflux protein P-gp is one of the main factors of MDR. P-gp expression is regulated by the signal transducer and act
Autor:
Koichiro Wada, Jingkai Sun, Motoo Araki, Masami Watanabe, Naijin Xu, Abai Xu, Peng Huang, Wenfeng Lin, Yasutomo Nasu, Takuya Sadahira, Chunxiao Liu
Publikováno v:
International Journal of Biological Sciences
Repeated cycles of first-line chemotherapy drugs such as doxorubicin (DOX) and cisplatin (CIS) trigger frequent chemoresistance in recurrent urothelial bladder cancer (UBC). Nitroxoline (NTX), an antibiotic to treat urinary tract infections, has been
Autor:
Yuanyuan Yu, Seongjin Park, Jingxian Li, Qingyun Zheng, Lei Liu, Yuan Xie, Minglei Zhao, Anthony A. Kossiakoff, Jingyi Fei, Man Pan, Satchal K. Erramilli
Publikováno v:
Nature Chemical Biology. 17:896-905
Protein ubiquitination shows remarkable topological and functional diversity through the polymerization of ubiquitin via different linkages. Deciphering the cellular ubiquitin code is of central importance to understand the physiology of the cell. Am
Autor:
Zhe Li, Xiuchong Yu, Xinjun Zhang, Linwen Zhu, Yijing Shen, Yongfu Shao, Yao Ruan, Guoliang Ye, Junming Guo
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Recently, tRNA-derived fragments (tRFs) have been shown to serve important biological functions. However, the role of tRFs in gastric cancer has not been fully elucidated. This study aimed to identify the tumor suppressor role of tRF-5026a