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Autor:
Erik Vlcak, Jana Šáchová, Jiří Novotný, Jan Brábek, Petr Přikryl, Daniel Rösel, Miluše Hradilová, Lucie Pfeiferová, Barbora Dvořánková, Jana Frýdlová, Martin Vokurka, Lukáš Lacina, Michal Kolář, Karolína Strnadová, Karel Smetana, Jana Šmigová
Publikováno v:
Histochemistry and Cell Biology. 157:153-172
The incidence of cutaneous malignant melanoma is increasing worldwide. While the treatment of initial stages of the disease is simple, the advanced disease frequently remains fatal despite novel therapeutic options . This requires identification of n
Autor:
Amanda Kofides, Kirsten Meid, Sara J. Buhrlage, Jinhua Wang, Manit Munshi, Jorge J. Castillo, Jiaji G. Chen, Kenneth C. Anderson, Michael D. Cameron, Guang Yang, Maria Luisa Guerrera, Xia Liu, Lian Xu, Nicholas Tsakmaklis, Nikhil C. Munshi, Jianwei Che, Li Tan, Maria Demos, Nathanael S. Gray, Christopher J. Patterson, Steven P. Treon, Zachary R. Hunter
Publikováno v:
Blood
Activating mutations in MYD88 promote malignant cell growth and survival through hematopoietic cell kinase (HCK)–mediated activation of Bruton tyrosine kinase (BTK). Ibrutinib binds to BTKCys481 and is active in B-cell malignancies driven by mutate
Autor:
Wei Dai, Junhong Wu, Lu Xie, Lingxia Chen, Fuhua Xie, Xinqiang Wu, Shenglan Liu, Liangmei He, Zhiping Liu
Publikováno v:
Cellular and Molecular Life Sciences. 78:8261-8281
Colorectal cancer (CRC) is the leading cause of cancer-related mortality worldwide, which makes it urgent to identify novel therapeutic targets for CRC treatment. In this study, DHX9 was filtered out as the prominent proliferation promoters of CRC by
Autor:
Mireia Martín-Satué, Marçal Pastor-Anglada, Loreto Boix, Clara Boces-Pascual, Aida Mata-Ventosa, Meritxell Gironella, Sandra Pérez-Torras
Publikováno v:
Cellular and Molecular Life Sciences
Dipòsit Digital de la UB
Universidad de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
Graphic abstract High-affinity uptake of natural nucleosides as well as nucleoside derivatives used in anticancer therapies is mediated by human concentrative nucleoside transporters (hCNTs). hCNT1, the hCNT family member that specifically transports
Autor:
Yoshimasa Tanaka, Mako Tomogane, Masatsugu Miyashita, Yusuke Sano, Shinya Kimura, Shigekuni Hosogi, Eishi Ashihara, Teruki Shimizu, Daiki Shimizu, Yuki Toda
Publikováno v:
Biochemical and Biophysical Research Communications. 573:132-139
Human γδ T cells expressing Vγ9Vδ2 T cell receptors play a crucial role in the innate immune system and have an attracted interest as effector cells in adoptive cellular immunotherapy. However, the efficacy of adoptive cellular immunotherapy for
Autor:
Wenjing Wu, Xiaojuan Xie, Limin Xie, Weijun Wu, Kaishun Hu, Chaoye Yang, Dong Yin, Jianli Zhao, Jianhong Xiao
Publikováno v:
Biochemical and Biophysical Research Communications. 573:62-68
Ring-finger protein 126 (RNF126), an E3 ubiquitin ligase, plays crucial roles in various biological processes, including cell proliferation, DNA damage repair, and intracellular vesicle trafficking. Whether RNF126 is modulated by posttranslational mo
Autor:
Lucy F. Yang, John P. Leonard, Gabriela Chiosis, M. Nieves Calvo-Vidal, Tony Taldone, Nikita Kotlov, Maria Victoria Revuelta, Catherine Thieblemont, Giorgio Inghirami, Peter Martin, Jan Krumsiek, Shao Ning Yang, Leandro Cerchietti, Rossella Marullo, Ekaterina Tikhonova, Jude M. Phillip, Nahuel Zamponi, Jayeshkumar Patel, Scott R. Manalis, Max A. Stockslager
Publikováno v:
Cancer Res
Prof. Manolis
Prof. Manolis
HSP90 is critical for maintenance of the cellular proteostasis. In cancer cells, HSP90 also becomes a nucleating site for the stabilization of multiprotein complexes including signaling pathways and transcription complexes. Here we described the role
Publikováno v:
Cell Biology International. 45:2129-2139
Colon adenocarcinoma (COAD) is the commonest type of colorectal cancer with high morbidity and mortality worldwide. ETS variant 4 (ETV4) is a member of the ETS transcription factors and is frequently involved in the progression of many cancers. This
Autor:
Jessica Oyie Sousa Onyeisi, Martin Götte, Ludwig Kiesel, Nancy Adriana Espinoza-Sánchez, Burkhard Greve, Carla Cristina Lopes
Publikováno v:
Journal of Cellular Biochemistry. 122:1491-1505
Syndecan-4, a predicted target of the microRNA miR-140-3p, plays an important role in multiple steps of tumor progression and is the second most abundant heparan sulfate proteoglycan produced by breast carcinoma cell lines. To investigate the potenti
Autor:
Sven Unger, Markus Christmann, Alicia Poplawski, Christian Schwarzenbach, H. Irem Baymaz, Juliana Brandstetter Vilar, Petra Beli, Maja T. Tomicic, Thomas R. Reich, Teodora Nikolova, Fabian Mühlhäusler
Publikováno v:
Cellular and Molecular Life Sciences
To clarify whether differential compartmentalization of Survivin impacts temozolomide (TMZ)-triggered end points, we established a well-defined glioblastoma cell model in vitro (LN229 and A172) and in vivo, distinguishing between its nuclear and cyto