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Publikováno v:
Cancer letters, Vol. 524 (2021) pp. 1-14
Glucose-related protein 78 (GRP78) is a chaperone protein localized primarily in the endoplasmic reticulum (ER) lumen, where it helps in proper protein folding by targeting misfolded proteins and facilitating protein assembly. In stressed cells, GRP7
Publikováno v:
Seminars in Cell & Developmental Biology. 121:10-23
Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytoto
Autor:
Wei Dai, Junhong Wu, Lu Xie, Lingxia Chen, Fuhua Xie, Xinqiang Wu, Shenglan Liu, Liangmei He, Zhiping Liu
Publikováno v:
Cellular and Molecular Life Sciences. 78:8261-8281
Colorectal cancer (CRC) is the leading cause of cancer-related mortality worldwide, which makes it urgent to identify novel therapeutic targets for CRC treatment. In this study, DHX9 was filtered out as the prominent proliferation promoters of CRC by
Autor:
Fatemeh Taheri, Soheila Fattahi, Mahdi Ghatrehsamani, Maryam Anjomshoa, Faramarz Mohammad Alibeigi, Nader Bagheri, Hedayatollah Shirzad, Monireh Karimi
Publikováno v:
Int J Exp Pathol
Bladder cancer (BC) is one of the most prevalent cancers around the world and, if not treated well, has high morbidity and mortality. Many studies have indicated that there may be various roles for the aryl hydrocarbon receptor (AHR) in the immune sy
Publikováno v:
Aging (Albany NY)
Antitumor immunotherapy can enable promising and durable responses following their clinical application. However, heterogeneity in the tumor immune microenvironment leads to differences in the individual response rates. In this study, we identified n
Publikováno v:
Aging (Albany NY)
Long noncoding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) is abnormally expressed in numerous tumors and functions as an oncogene, but the role of NEAT1 in laryngocarcinoma is largely unknown. Our study validated that NEAT1 expressi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
STEAP3 (Six-transmembrane epithelial antigen of the prostate 3, TSAP6, dudulin-2) has been reported to be involved in tumor progression in human malignancies. Nevertheless, how it participates in the progression of human cancers, especially HCC, is s
Publikováno v:
Journal of Cellular and Molecular Medicine
The cell division cycle associated 8 (CDCA8) is a crucial component of the chromosome passenger complex (CPC). It has been implicated in the regulation of cell dynamic localization during mitosis. However, its role in hepatocellular carcinoma (HCC) i
Publikováno v:
Aging (Albany NY)
Fibroblast-like synoviocytes (FLS) obtained from the joint synovium of rheumatoid arthritis (RA) patients exhibit hyperplasia and aggressive inflammatory phenotypes. This study was designed to explore the anti-inflammatory mechanism of IL-6R inhibito
Autor:
Brian S. Gloss, Kavitha Gowrishankar, Piers Blombery, Raymond H. Y. Louie, Kenneth P. Micklethwaite, Emily Blyth, Fritz J. Sedlazeck, Janine Street, David Gottlieb, Matthew MacKay, Christopher E. Mason, David Bishop, Leili Moezzi, Gaurav Sutrave, Curtis Cai, Ziduo Li, Leighton Clancy, Fabio Luciani, Jonathan Foox, Melanie A Mach
Publikováno v:
Blood. 138:1391-1405
We performed a phase 1 clinical trial to evaluate outcomes in patients receiving donor-derived CD19-specific chimeric antigen receptor (CAR) T cells for B-cell malignancy that relapsed or persisted after matched related allogeneic hemopoietic stem ce