Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sergio Valente"'
Autor:
Licheng Zhu, Wenhu Duan, Jinrong Min, Kongkai Zhu, Shijie Fan, Giulia Stazi, Clemens Zwergel, Xiangqian Kong, Hualiang Jiang, Kaiyan Zhao, Daohai Du, Yuanqing Li, Naixia Zhang, Yuanyuan Zhang, Yanli Liu, Kehao Zhao, Sergio Valente, Zhongyuan Luo, Yiluan Ding, Dandan Xu, Jingqiu Liu, Cheng Luo, Kaixian Chen
Disruption of EZH2-embryonic ectoderm development (EED) protein-protein interaction (PPI) is a new promising cancer therapeutic strategy. We have previously reported the discovery of astemizole, a small-molecule inhibitor targeting the EZH2-EED PPI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7769f96723b0c2c58a9cf6ad8b9e50a
http://hdl.handle.net/11573/1550470
http://hdl.handle.net/11573/1550470
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry, Vol 8 (2020)
Numerous and different types of cancers possess the dysregulation of the mevalonate pathway as a common feature. Statins, traditionally applied in cardiovascular diseases to reduce lipid levels, subsequently have been discovered to exhibit anti-cance
Autor:
Daniel I. Benjamin, Alessandro Aliverti, Antonello Mai, Sergio Valente, Biagina Marrocco, Daniel K. Nomura, Andrea Mattevi, Simone Nenci, Valentina Piano
Publikováno v:
ACS Chemical Biology. 10:2589-2597
Dysregulated ether lipid metabolism is an important hallmark of cancer cells. Previous studies have reported that lowering ether lipid levels by genetic ablation of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS) lowers ke
Autor:
Claus Jacob, Denise Bagrel, Bruno Botta, Brigitte Czepukojc, Zhanjie Xu, Gilbert Kirsch, Clemens Zwergel, Peter Meiser, Rino Ragno, Alexandros Patsilinakos, Mattia Mori, Mathias Montenarh, Emilie Evain-Bana, Antonello Mai, Sergio Valente, Giulia Stazi
Publikováno v:
European journal of medicinal chemistry. 134
Cell division cycle phosphatases CDC25 A, B and C are involved in modulating cell cycle processes and are found overexpressed in a large panel of cancer typology. Here, we describe the development of two novel quinone-polycycle series of CDC25A and C
Autor:
Paolo Mellini, Donatella Del Bufalo, Sébastien Moniot, Lucia Polletta, Clemens Steegborn, Marco Tafani, Ilaria Carnevale, Roberta Budriesi, Maria Tardugno, Lucia Altucci, Chiara Gabellini, Sandra Atlante, Daniela Trisciuoglio, Antonello Mai, Vincenzo Carafa, Angela Nebbioso, Serena Saladini, Sergio Valente, Francesco Spallotta, Clemens Zwergel, Chiara Cencioni, Carlo Gaetano
Publikováno v:
Journal of medicinal chemistry (2016).
info:cnr-pdr/source/autori:Valente S, Mellini P, Spallotta F, Carafa V, Nebbioso A, Polletta L, Carnevale I, Saladini S, Trisciuoglio D, Gabellini C, Tardugno M, Zwergel C, Cencioni C, Atlante S, Moniot S, Steegborn C, Budriesi R, Tafani M, Del Bufalo D, Altucci L, Gaetano C, Mai A./titolo:1,4-Dihydropyridines Active on the SIRT1%2FAMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells./doi:/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume
info:cnr-pdr/source/autori:Valente S, Mellini P, Spallotta F, Carafa V, Nebbioso A, Polletta L, Carnevale I, Saladini S, Trisciuoglio D, Gabellini C, Tardugno M, Zwergel C, Cencioni C, Atlante S, Moniot S, Steegborn C, Budriesi R, Tafani M, Del Bufalo D, Altucci L, Gaetano C, Mai A./titolo:1,4-Dihydropyridines Active on the SIRT1%2FAMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells./doi:/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume
Modulators of sirtuins are considered promising therapeutic targets for the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases. Here we prepared new 1,4-dihydropyridines (DHPs) bearing changes at the C2/C6, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4bbdf098839e19177d1bd2f68f8889
http://hdl.handle.net/11573/870523
http://hdl.handle.net/11573/870523
Autor:
Nathaniel Edward Bennett Saidu, Denyse Bagrel, Gilbert Kirsch, Sergio Valente, Mathias Montenarh, Emilie Bana
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:1584-1593
Coumarins and coumarin derivatives as well as diallyl polysulfides are well known as anticancer drugs. In order to find new drugs with anticancer activities, we combined coumarins with polysulfides in the form of di-coumarin polysulfides. These novel
Autor:
François Gaascht, Gilbert Kirsch, Clemens Zwergel, Antonello Mai, Sergio Valente, Marc Diederich, Michael Schnekenburger, Mario Dicato, Carole Seidel
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (16), pp.3797-3801. ⟨10.1016/j.bmcl.2014.06.067⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (16), pp.3797-3801. ⟨10.1016/j.bmcl.2014.06.067⟩
International audience; Histone deacetylases (HDACs) are well-established, promising targets for anticancer therapy due to their critical role in cancer development. Accordingly, an increasing number of HDAC inhibitors displaying cytotoxic effects ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04d1b4ec01fbb9ec38413de909f89f8
https://hal.univ-lorraine.fr/hal-01494600
https://hal.univ-lorraine.fr/hal-01494600