Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sergio Valente"'
Autor:
Licheng Zhu, Wenhu Duan, Jinrong Min, Kongkai Zhu, Shijie Fan, Giulia Stazi, Clemens Zwergel, Xiangqian Kong, Hualiang Jiang, Kaiyan Zhao, Daohai Du, Yuanqing Li, Naixia Zhang, Yuanyuan Zhang, Yanli Liu, Kehao Zhao, Sergio Valente, Zhongyuan Luo, Yiluan Ding, Dandan Xu, Jingqiu Liu, Cheng Luo, Kaixian Chen
Disruption of EZH2-embryonic ectoderm development (EED) protein-protein interaction (PPI) is a new promising cancer therapeutic strategy. We have previously reported the discovery of astemizole, a small-molecule inhibitor targeting the EZH2-EED PPI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7769f96723b0c2c58a9cf6ad8b9e50a
http://hdl.handle.net/11573/1550470
http://hdl.handle.net/11573/1550470
Autor:
Daniel I. Benjamin, Alessandro Aliverti, Antonello Mai, Sergio Valente, Biagina Marrocco, Daniel K. Nomura, Andrea Mattevi, Simone Nenci, Valentina Piano
Publikováno v:
ACS Chemical Biology. 10:2589-2597
Dysregulated ether lipid metabolism is an important hallmark of cancer cells. Previous studies have reported that lowering ether lipid levels by genetic ablation of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS) lowers ke
Autor:
Claus Jacob, Denise Bagrel, Bruno Botta, Brigitte Czepukojc, Zhanjie Xu, Gilbert Kirsch, Clemens Zwergel, Peter Meiser, Rino Ragno, Alexandros Patsilinakos, Mattia Mori, Mathias Montenarh, Emilie Evain-Bana, Antonello Mai, Sergio Valente, Giulia Stazi
Publikováno v:
European journal of medicinal chemistry. 134
Cell division cycle phosphatases CDC25 A, B and C are involved in modulating cell cycle processes and are found overexpressed in a large panel of cancer typology. Here, we describe the development of two novel quinone-polycycle series of CDC25A and C