Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gregory B Lesinski"'
Autor:
Wanqi Chen, Dong M. Shin, Sreenivas Nannapaneni, Andreas Wieland, Rafi Ahmed, Gregory B. Lesinski, Mihir R. Patel, Christopher C. Griffith, Zhengjia Chen, Zhuo Georgia Chen, Nabil F. Saba
Publikováno v:
Head and Neck Pathology. 13:304-312
This study addresses the hypothesis that IL-6/STAT3 signaling is of clinical relevance in oropharyngeal squamous cell carcinoma (OPSCC). We evaluated relationships between key components of this pathway in tumors from a unique cohort of n = 59 fully
Autor:
K. Roberts, Zobeida Cruz-Monserrate, Jennifer Ahn-Jarvis, Mitchell L. Ramsey, Phil A. Hart, Sabrina Kaul, Olivia Crowe, Niharika Badi, Yael Vodovotz, Darwin L. Conwell, Erin Marie Lombardo, Somashekar G. Krishna, Kyle R. Stinehart, Hannah Komar, Thomas A. Mace, Madelyn Traczek, Gregory B. Lesinski
Publikováno v:
Pancreatology
Introduction Chronic pancreatitis is a chronic inflammatory disease, which progresses to fibrosis. Currently there are no interventions to delay or stop the progression to irreversible organ damage. In this study, we assessed the tolerability and fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7b698bfa12ad6fb8f8ac1e27c3c0c5
https://europepmc.org/articles/PMC7780088/
https://europepmc.org/articles/PMC7780088/
Autor:
Gregory B. Lesinski, Bassel F. El-Rayes, Ganji Purnachandra Nagaraju, Gayathri Chalikonda, Matthew R. Farren, Christina Wu, Batoul Farran
Publikováno v:
Cancer
Background: The induction of reactive oxygen species (ROS) represents a viable strategy for enhancing the activity of radiotherapy. The authors hypothesized that napabucasin would increase ROS via its ability to inhibit NAD(P)H:quinone oxidoreductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cb66011f8d020833a844246d86d595
https://europepmc.org/articles/PMC7380507/
https://europepmc.org/articles/PMC7380507/
Autor:
Xueliang Pan, Gregory B. Lesinski, Jeffrey Schlom, Renee N. Donahue, Thomas Olencki, Jacob Richards, Taylor R. Brooks, Volodymyr Karpa, Bonnie Paul, William E. Carson, Caroline Jochems, Megan C. Duggan, Elizabeth Foust, Susheela Tridandapani
Publikováno v:
Cancer Immunology, Immunotherapy. 65:1353-1364
Prime-boost vaccination with recombinant (r) vaccinia(V)-CEA(6D)-TRICOM (triad of co-stimulatory molecules B7.1, ICAM-1 and LFA-3) and rFowlpox(F)-CEA(6D)-TRICOM infect antigen-presenting cells and direct expression of co-stimulatory molecules. We hy
Autor:
Gregory B. Lesinski, Olatunji B. Alese, Christina Wu, Walid L. Shaib, Mehmet Akce, Bassel F. El-Rayes
Publikováno v:
Journal of Clinical Oncology. 38:830-830
830 Background: XL888 is a selective inhibitor of heat shock protein 90 (HSP90). It modulates several oncogenic signaling pathways, and the tumor microenvironment. In preclinical models, XL888 potentiates efficacy of PD-1 inhibition. We report the re
Autor:
Luis I. Ruffolo, Maurice Zauderer, Brian Olson, Gregory B. Lesinski, Alexander C. Chacon, Mary A. Georger, Brian A. Belt, Elizabeth E. Evans, David C. Linehan, Crystal Mallow, Katherine M. Jackson, Paul R. Burchard, Rachel Jewell, Peter A. Prieto, Christina Wu, Terrence L. Fisher, Nicholas A. Ullman, Alexa Melucci
Publikováno v:
Cancer Research. 79:B48-B48
Background: Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality, with dismal 5-year prognosis of 8%, in part due to poor response to available therapies. Thus, new systemic cancer control therapies are in dire nee
Autor:
Hannah M. Komar, Darwin L. Conwell, Zobeida Cruz-Monserrate, Phil A. Hart, Gregory B. Lesinski
Inflammatory and fibrotic events that drive chronic pancreatitis (CP) are likely orchestrated via signaling of soluble cytokines and chemokines systemically and within the pancreas. However, a comprehensive summary of the expression of such factors d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df4011b0930a203a394f997a92faf3a
https://europepmc.org/articles/PMC5774026/
https://europepmc.org/articles/PMC5774026/
Autor:
Tanios Bekaii-Saab, Jon P. Walker, Walter J. Coyle, Mark Bloomston, Gregory B. Lesinski, Lawrence A. Shirley, Christopher L. Marsh, Daniel Sanchez, Estuardo Aguilar-Cordova, Andrea G. Manzanera, Howard Marx, Vincent Chung, Laura K. Aguilar, Benjamin Swanson
Publikováno v:
Cancer Immunology, Immunotherapy. 64:727-736
While surgical resection of pancreatic adenocarcinoma provides the only chance of cure, long-term survival remains poor. Immunotherapy may improve outcomes, especially as adjuvant to local therapies. Gene-mediated cytotoxic immunotherapy (GMCI) gener
Autor:
Ming-Chen Yang, Phil A. Hart, Gregory B. Lesinski, Hannah M. Komar, Erin Schwoegl, Darwin L. Conwell, Michael C. Ostrowski, Ching-Shih Chen, Gregory Serpa, Ming Jin, Mark Bloomston, Thomas A. Mace, Claire Kerscher
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and pancreatic insufficiency. No therapeutic options exist due to a limited understanding of the biology of CP pathology. Recent findings implicate pancreatic st
Autor:
Susan N. Thomas, Brian Pollack, Gregory B. Lesinski, Yun Min Chang, Maiko Sasaki, Edmund K. Waller, Anna E. Kersh, Haydn T. Kissick, Spencer Ng, Ragini R. Kudchadkar
Publikováno v:
Journal of clinical pharmacology. 58(1)
Two pharmacologic approaches that are currently at the forefront of treating advanced cancer are those that center on disrupting critical growth/survival signaling pathways within tumor cells (commonly referred to as "targeted therapies") and those t