Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Philip T. Liu"'
Autor:
Kislay Parvatiyar, Robert L. Modlin, Euzenir Nunes Sarno, Barry R. Bloom, Genhong Cheng, Rosane M. B. Teles, Philip T. Liu, Maria Teresa Ochoa, Annalisa Legaspi, Aaron Choi, Angeline Tilly Dang, Michel Gilliet
Publikováno v:
JCI insight, vol 4, iss 8
Dang, Angeline Tilly; Teles, Rosane Mb; Liu, Phillip T; Choi, Aaron; Legaspi, Annalisa; Sarno, Euzenir N; et al.(2019). Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.. JCI insight, 4(8). doi: 10.1172/jci.insight.126955. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6584h5s6
Dang, Angeline Tilly; Teles, Rosane Mb; Liu, Phillip T; Choi, Aaron; Legaspi, Annalisa; Sarno, Euzenir N; et al.(2019). Autophagy links antimicrobial activity with antigen presentation in Langerhans cells.. JCI insight, 4(8). doi: 10.1172/jci.insight.126955. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6584h5s6
DC, through the uptake, processing, and presentation of antigen, are responsible for activation of T cell responses to defend the host against infection, yet it is not known if they can directly kill invading bacteria. Here, we studied in human lepro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ce097a4e0c936b51446479a4aae72c
https://escholarship.org/uc/item/6584h5s6
https://escholarship.org/uc/item/6584h5s6
Autor:
Kathryn Zavala, Carter A. Gottlieb, Martin Hewison, Robert L. Modlin, John S. Adams, Rosane M. B. Teles, Philip T. Liu
Publikováno v:
PLoS Neglected Tropical Diseases
Zavala, Kathryn; Gottlieb, Carter A; Teles, Rosane M; Adams, John S; Hewison, Martin; Modlin, Robert L; et al.(2018). Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN.. PLoS neglected tropical diseases, 12(10), e0006815. doi: 10.1371/journal.pntd.0006815. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4tr261r6
PLoS neglected tropical diseases, vol 12, iss 10
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006815 (2018)
Zavala, Kathryn; Gottlieb, Carter A; Teles, Rosane M; Adams, John S; Hewison, Martin; Modlin, Robert L; et al.(2018). Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN.. PLoS neglected tropical diseases, 12(10), e0006815. doi: 10.1371/journal.pntd.0006815. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4tr261r6
PLoS neglected tropical diseases, vol 12, iss 10
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006815 (2018)
Following infection, virulent mycobacteria persist and grow within the macrophage, suggesting that the intrinsic activation of an innate antimicrobial response is subverted by the intracellular pathogen. For Mycobacterium leprae, the intracellular ba
Publikováno v:
PLoS neglected tropical diseases, vol 12, iss 7
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006608 (2018)
Kim, Elliot W; Teles, Rosane MB; Haile, Salem; Liu, Philip T; & Modlin, Robert L. (2018). Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.. PLoS neglected tropical diseases, 12(7), e0006608. doi: 10.1371/journal.pntd.0006608. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wg8k5pv
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006608 (2018)
Kim, Elliot W; Teles, Rosane MB; Haile, Salem; Liu, Philip T; & Modlin, Robert L. (2018). Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.. PLoS neglected tropical diseases, 12(7), e0006608. doi: 10.1371/journal.pntd.0006608. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wg8k5pv
Background The immune system depends on effector pathways to eliminate invading pathogens from the host in vivo. Macrophages (MΦ) of the innate immune system are armed with vitamin D-dependent antimicrobial responses to kill intracellular microbes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4023b30d30128e6754c351e1e50a0d
https://escholarship.org/uc/item/6wg8k5pv
https://escholarship.org/uc/item/6wg8k5pv
Autor:
Matteo Pellegrini, Avelino De Leon, Philip T. Liu, Megan S. Inkeles, Stephan R. Krutzik, Elliot W. Kim, Matthew Wheelwright
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 192, iss 5
A role for vitamin A in host defense against Mycobacterium tuberculosis has been suggested through epidemiological and in vitro studies; however, the mechanism is unclear. In this study, we demonstrate that vitamin A–triggered antimicrobial activit
Autor:
Adam J. Friedman, Jackson Champer, Karin Blecher-Paz, Min Qin, Jenny Kim, David Schairer, Ami Oren, Jenny Phan, Philip T. Liu, Aslan Pirouz, Robert L. Modlin
Publikováno v:
The Journal of investigative dermatology, vol 133, iss 5
Advances in nanotechnology have demonstrated potential application of nanoparticles (NPs) for effective and targeted drug delivery. Here we investigated the antimicrobial and immunological properties and the feasibility of using NPs to deliver antimi
Autor:
Robert L. Modlin, Stephan R. Krutzik, Steffen Stenger, Andrea Sommer, Mario Fabri, Philip T. Liu, Georgiana M Klug-Micu
Publikováno v:
Immunology. 139:121-128
The ability of T cells to activate antimicrobial pathways in infected macrophages is essential to host defence against many intracellular pathogens. Here, we compared the ability of two T-cell-mediated mechanisms to trigger antimicrobial responses ag
Autor:
Rosane M. B. Teles, Philip T. Liu, Robert L. Modlin, Nathan W. Schmidt, Mirjam Schenk, Matteo Pellegrini, Gerard C. L. Wong, Susan Realegeno, Thomas H. Rea, Kindra M. Kelly-Scumpia, Ernest Y. Lee, Maria Teresa Ochoa, Angeline Tilly Dang, Jing Lu, Euzenir Nunes Sarno
Publikováno v:
PLoS Pathogens
Realegeno, Susan; Kelly-Scumpia, Kindra M; Dang, Angeline Tilly; Lu, Jing; Teles, Rosane; Liu, Philip T; Schenk, Mirjam; Lee, Ernest Y; Schmidt, Nathan W; Wong, Gerard C L; Sarno, Euzenir N; Rea, Thomas H; Ochoa, Maria T; Pellegrini, Matteo; Modlin, Robert L (2016). S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS pathogens, 12(6), e1005705. Public Library of Science 10.1371/journal.ppat.1005705
PLoS pathogens, vol 12, iss 6
PLoS Pathogens, Vol 12, Iss 6, p e1005705 (2016)
Realegeno, Susan; Kelly-Scumpia, Kindra M; Dang, Angeline Tilly; Lu, Jing; Teles, Rosane; Liu, Philip T; Schenk, Mirjam; Lee, Ernest Y; Schmidt, Nathan W; Wong, Gerard C L; Sarno, Euzenir N; Rea, Thomas H; Ochoa, Maria T; Pellegrini, Matteo; Modlin, Robert L (2016). S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS pathogens, 12(6), e1005705. Public Library of Science 10.1371/journal.ppat.1005705
PLoS pathogens, vol 12, iss 6
PLoS Pathogens, Vol 12, Iss 6, p e1005705 (2016)
Triggering antimicrobial mechanisms in macrophages infected with intracellular pathogens, such as mycobacteria, is critical to host defense against the infection. To uncover the unique and shared antimicrobial networks induced by the innate and adapt
Autor:
Elliot W. Kim, Santhosh M. Nadipuram, Ashley L. Tetlow, William D. Barshop, Philip T. Liu, James A. Wohlschlegel, Peter J. Bradley, Ira J. Blader
Publikováno v:
mSphere
mSphere, Vol 1, Iss 2, p e00045-16 (2016)
mSphere, Vol 1, Iss 2 (2016)
mSphere, Vol 1, Iss 2, p e00045-16 (2016)
mSphere, Vol 1, Iss 2 (2016)
The interactions between intracellular microbes and their host cells can lead to the discovery of novel drug targets. During Toxoplasma infections, host cells express an array of immunity-related GTPases (IRGs) and guanylate binding proteins (GBPs) t
Publikováno v:
Clinical Reviews in Bone and Mineral Metabolism. 7:176-184
This chapter will examine the role of vitamin D in the innate immune system as a mediator of human host defense mechanisms microbial disease, focusing on tuberculosis. The first section will examine tuberculosis and the innate immune response to the
Autor:
Jenny Kim, Melissa Kanchanapoomi, Dominic Ho-Ping Tang, Brian E. Hall, Jenny Phan, Stephan R. Krutzik, Philip T. Liu
Publikováno v:
The Journal of Immunology. 180:4919-4923
Propionibacterium acnes is a major etiological factor of acne, triggering an inflammatory response in part through the activation of TLR2. In this study, we demonstrate that activation of peripheral blood monocytes with P. acnes in vitro induced thei