Zobrazeno 1 - 10
of 27
pro vyhledávání: '"James G. Kublin"'
Autor:
Shirley Galbiati, Jessie K. Kennedy, Thomas L. Richie, Stephen L. Hoffman, Natasha Kc, Lisa A. Jackson, Sumana Chakravarty, Eric R. James, Yonas Abebe, B. Kim Lee Sim, James G. Kublin, Sean C. Murphy, Kristen W. Cohen, Gregory A. Deye
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009594 (2021)
PLoS Pathogens
PLoS Pathogens
PfSPZ-CVac combines ‘PfSPZ Challenge’, which consists of infectious Plasmodium falciparum sporozoites (PfSPZ), with concurrent antimalarial chemoprophylaxis. In a previously-published PfSPZ-CVac study, three doses of 5.12x104 PfSPZ-CVac given 28
Autor:
Anthony Williams, Georgia D. Tomaras, Andrew Fiore-Gartland, One B. Dintwe, Kathryn Tucker Rutkowski, Aeras A Protocol Team, Peter Andersen, Keren Middelkoop, Hvtn, Kelly E. Seaton, M. Juliana McElrath, Linda-Gail Bekker, Erica Andersen-Nissen, James G. Kublin, Ann M. Ginsberg, Dereck Tait, Stephen C. De Rosa, Ingrid Kromann, Julia Hutter, Carlos A. DiazGranados, April K. Randhawa, Morten Ruhwald, Maurine D. Miner
Publikováno v:
EClinicalMedicine, Vol 21, Iss, Pp-(2020)
EClinicalMedicine
EClinicalMedicine
Background: Tuberculosis (TB) remains the leading cause of infectious disease-related death. Recently, a trial of BCG revaccination and vaccination with H4:IC31, a recombinant protein vaccine, in South African adolescents (Aeras C-040-404) showed eff
Autor:
Andrew Fiore-Gartland, James G. Kublin, Giuseppe Pantaleo, Shelly Karuna, Jacob A. Cram, Sujatha Srinivasan, David N. Fredricks, Georgia D. Tomaras
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0225622 (2019)
PLoS ONE, Vol 14, Iss 12, p e0225622 (2019)
Antibodies that recognize commensal microbial antigens may be cross reactive with a part of the human immunodeficiency virus (HIV) envelope glycoprotein gp41. To improve understanding of the role of the microbiota in modulating the immune response to
Autor:
Benjamin Mordmüller, Sean C. Murphy, James G. Kublin, Leesa F. Wockner, James S. McCarthy, Isabell Hoffmann, Peter O'Rourke, Louise Marquart, Lachlan Webb
Publikováno v:
The Journal of Infectious Diseases
Background Growth rate of malaria parasites in the blood of infected subjects is an important measure of efficacy of drugs and vaccines. Methods We used log-linear and sine-wave models to estimate the parasite growth rate of the 3D7 strain of Plasmod
Autor:
Kevin Gillespie, Nicole Andenmatten, Youyi Fong, Stefan H. I. Kappe, Holly Janes, Ryan L. Jensen, Nicola Kerr, Annette M. Seilie, Sean R. Marcsisin, Jörg J. Möhrle, Amelia E. Hanron, Tracie VonGoedert, Sue Ferguson, Kelly J. Shipman, Elizabeth R. Duke, James G. Kublin, Stephan Duparc, Laurie Rinn, Thomas Rueckle, Emma Fritzen, Matthew Fishbaugher, Ming Chang, Stephan Chalon, Jason C. Sousa, Sean C. Murphy
Publikováno v:
The Journal of Infectious Diseases. 217:693-702
Background DSM265 is a selective inhibitor of Plasmodium dihydroorotate dehydrogenase that fully protected against controlled human malarial infection (CHMI) by direct venous inoculation of Plasmodium falciparum sporozoites when administered 1 day be
Autor:
Steve Kuntz, Patrick E. Duffy, Sara A. Healy, Anna Wald, Stefan H. I. Kappe, Jen C. C. Hume, Ruobing Wang, Sean R. Marcsisin, Angela K Talley, Mark Kennedy, Richa Chaturvedi, Olivia C Finney, Kenneth Stuart, Sean C. Murphy, Barbara Metch, Lisa Shelton, Sharon Wong-Madden, Margaret Warner-Lubin, Matthew Fishbaugher, Wesley C. Van Voorhis, Charlotte V. Hobbs, James G. Kublin, Zoe Moodie, Tiffany Silver-Brace
Publikováno v:
Clin Infect Dis
Background Chemoprophylaxis vaccination with sporozoites (CVac) with chloroquine induces protection against a homologous Plasmodium falciparum sporozoite (PfSPZ) challenge, but whether blood-stage parasite exposure is required for protection remains
Autor:
Ashley M. Vaughan, Annette M. Seilie, Emma Fritzen, Tracie VonGoedert, Heather S. Kain, Will Betz, Brandon K. Sack, Sara Magee, Sean C. Murphy, Stefan H. I. Kappe, Matt E. Fishbaugher, Lisa Shelton, Melike Firat, Dorender A. Dankwa, Sebastian A. Mikolajczak, James G. Kublin, Ryan W.J. Steel, D. Noah Sather
Publikováno v:
Science translational medicine. 9(371)
Immunization of humans with whole sporozoites confers complete, sterilizing immunity against malaria infection. However, achieving consistent safety while maintaining immunogenicity of whole parasite vaccines remains a formidable challenge. We genera
Autor:
Miriam K. Laufer, James G. Kublin, Elena Artimovich, Shannon Takala-Harrison, Kristan A. Schneider, Ananias A. Escalante, Christopher V. Plowe, Fraction K. Dzinjalamala, Terrie E. Taylor
Background. In 2007, Malawi replaced sulfadoxine-pyrimethamine (SP) with an artemisinin-based combination therapy as the first-line treatment for uncomplicated Plasmodium falciparum malaria in response to failing SP efficacy. Here we estimate the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d41aa9ad45fc77f4d38fc35340f39a
https://europepmc.org/articles/PMC4539899/
https://europepmc.org/articles/PMC4539899/
Publikováno v:
Science. 314:1603-1606
Mounting evidence has revealed pathological interactions between HIV and malaria in dually infected patients, but the public health implications of the interplay have remained unclear. A transient almost one-log elevation in HIV viral load occurs dur
Autor:
Christopher V. Plowe, Karen I. Barnes, Pete Smith, Malcolm E. Molyneux, Fraction K. Dzinjalamala, Allan Macheso, Terrie E. Taylor, James G. Kublin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:3601-3606
Sulfadoxine-pyrimethamine (SP) has been widely used in recent years to treat acute uncomplicated Plasmodium falciparum malaria. Risk factors for SP therapeutic failure include young age, subtherapeutic SP concentrations, and resistance-conferring gen