Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Francesca Blasco"'
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Autor:
Francesca Blasco, Suresh B. Lakshminarayana, Thierry T. Diagana, Jing Yu, Christoph Fischli, Sebastian Weber, Paul C. Ho, Matthias Rottmann, Véronique Dartois, Bryan K. S. Yeung, Céline Freymond, Anne Goh
Publikováno v:
Antimicrobial Agents and Chemotherapy
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone
Autor:
Thierry T. Diagana, Suresh B. Lakshminarayana, Susan Noh, Francesca Blasco, Carrie F. Brooks, Jennifer A. Zambriski, Laura B. Goodman, Gu Feng, Sumiti Vinayak, Gillian T. Herbert, Peter Gedeck, Lijun Zhang, Jayesh Tandel, Siau H. Lim, Christian G. Noble, F. Joel Leong, Alex Chao, Juergen Wagner, Bin Zou, Boris Striepen, Tracy Sy, Ravinder Reddy Kondreddi, Christophe Bodenreider, Ujjini H. Manjunatha, Ghislain M. C. Bonamy, Adam Sateriale
Publikováno v:
Nature
Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly grave impact on infants and immunocompr
Autor:
Ujjini H. Manjunatha, Richard Glynne, John R. Walker, Bee Huat Tan, Paul W. Smith, Srinivasa P. S. Rao, Kelli Kuhen, Pearly Shuyi Ng, Christian G. Noble, Susan W. Barnes, Peter J. Tonge, Seow H. Ng, Suresh B. Lakshminarayana, Ng L. Ma, Ravinder Reddy Kondreddi, Francesca Blasco, Thierry T. Diagana, David Beer, Maxime Herve, Weixuan Yu, Luis R. Camacho
Publikováno v:
Science Translational Medicine. 7
New chemotherapeutic agents are urgently required to combat the global spread of multidrug-resistant tuberculosis (MDR-TB). The mycobacterial enoyl reductase InhA is one of the few clinically validated targets in tuberculosis drug discovery. We repor
Autor:
Kerstin Gagaring, Sindhu Ravindran, Pablo Bifani, Gu Feng, Peck Gee Seah, Kelli Kuhen, Zhong Chen, Sarath K. Kalapala, Maxime Herve, Pamela Thayalan, Thierry T. Diagana, Arnab K. Chatterjee, Jan Jiricek, Anne Goh, Seow H. Ng, Thomas Dick, Whitney Barnes, Francesca Blasco, Richard Glynne, Lijun Zhang, Véronique Dartois, Siao H. Lim, John R. Walker, Margaret Weaver, David Beer, Luis R. Camacho, Mahesh Nanjundappa, Kevin Pethe, Paul W. Smith, Ujjini H. Manjunatha, Boon H. Lee, Srinivasa P. S. Rao, Bee Huat Tan, Sreehari Babu, Suresh B. Lakshminarayana, Ng L. Ma, Ravinder Reddy Kondreddi
Publikováno v:
Science translational medicine. 5(214)
New chemotherapeutic compounds against multidrug-resistant Mycobacterium tuberculosis (Mtb) are urgently needed to combat drug resistance in tuberculosis (TB). We have identified and characterized the indolcarboxamides as a new class of antitubercula
Publikováno v:
The Journal of biological chemistry. 278(1)
The second structure of a thermophile cytochrome P450, CYP175A1 from the thermophilic bacterium Thermus thermophilus HB27, has been solved to 1.8-A resolution. The overall P450 structure remains conserved despite the low sequence identity between the
Autor:
Helena I. Boshoff, Francesca Blasco, Sindhu Ravindran, Thomas Dick, Mahesh Nanjundappa, Paul C. Ho, Jan Jiricek, Clifton E. Barry, Anne Goh, Joseph Cherian, Ramandeep Singh, Suresh B. Lakshminarayana, Amit Nayyar, Ujjini H. Manjunatha, Meera Gurumurthy
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e105222 (2014)
PLoS ONE, Vol 9, Iss 8, p e105222 (2014)
PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during