Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elaine Bignell"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1012105 (2024)
Quantifying fungal growth underpins our ability to effectively treat severe fungal infections. Current methods quantify fungal growth rates from time-course morphology-specific data, such as hyphal length data. However, automated large-scale collecti
Externí odkaz:
https://doaj.org/article/959046aa6f9b4e11a69665bce9a14bbb
Autor:
Monica Sueiro-Olivares, Jennifer Scott, Sara Gago, Dunja Petrovic, Emilia Kouroussis, Jasmina Zivanovic, Yidong Yu, Marlene Strobel, Cristina Cunha, Darren Thomson, Rachael Fortune-Grant, Sina Thusek, Paul Bowyer, Andreas Beilhack, Agostinho Carvalho, Elaine Bignell, Milos R Filipovic, Jorge Amich
Publikováno v:
PLoS Biology, Vol 19, Iss 6, p e3001247 (2021)
Aspergillus fumigatus is a human fungal pathogen that can cause devastating pulmonary infections, termed "aspergilloses," in individuals suffering immune imbalances or underlying lung conditions. As rapid adaptation to stress is crucial for the outco
Externí odkaz:
https://doaj.org/article/37901fc4cdd74f5db14e4cc0150142f0
Autor:
Markus Schrettl, Elaine Bignell, Claudia Kragl, Yasmin Sabiha, Omar Loss, Martin Eisendle, Anja Wallner, Herbert N Arst, Ken Haynes, Hubertus Haas
Publikováno v:
PLoS Pathogens, Vol 3, Iss 9, Pp 1195-1207 (2007)
Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen. We have previously demonstrated that
Externí odkaz:
https://doaj.org/article/bba175b549eb4c239cf95aa34c11cc84
Autor:
Andrew McDonagh, Natalie D Fedorova, Jonathan Crabtree, Yan Yu, Stanley Kim, Dan Chen, Omar Loss, Timothy Cairns, Gustavo Goldman, Darius Armstrong-James, Ken Haynes, Hubertus Haas, Markus Schrettl, Gregory May, William C Nierman, Elaine Bignell
Publikováno v:
PLoS Pathogens, Vol 4, Iss 9, p e1000154 (2008)
Aspergillus fumigatus is a common mould whose spores are a component of the normal airborne flora. Immune dysfunction permits developmental growth of inhaled spores in the human lung causing aspergillosis, a significant threat to human health in the
Externí odkaz:
https://doaj.org/article/8102d0436da64919bd20474d8920d4bb
Autor:
Daniel A. Henk, Elaine Bignell, Heiman F. L. Wertheim, William C. Nierman, Kwok-Yung Yuen, Matthew C. Fisher, Po-Ren Hsueh, Nongnuch Vanittanakom, Alex Andrianopoulos, Tran P M Sieu, Natalie D. Fedorova, Khuraijam Ranjana Devi, Kylie J. Boyce, Nguyen Van Kinh, Stephen Baker, Jeremy N. Day, Revital Shahar-Golan, Nengyong Zhan
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002851 (2012)
PLoS Pathogens
PLoS Pathogens
Molecular genetic approaches typically detect recombination in microbes regardless of assumed asexuality. However, genetic data have shown the AIDS-associated pathogen Penicillium marneffei to have extensive spatial genetic structure at local and reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded5e2a1b7a9aa9947c9fd594bb25cf9
https://ora.ox.ac.uk/objects/uuid:d6fb19c5-53ae-4c05-8f39-61b13072aab3
https://ora.ox.ac.uk/objects/uuid:d6fb19c5-53ae-4c05-8f39-61b13072aab3
Autor:
Darius Armstrong-James, Maryam Safari, Hong Liu, Elaine Bignell, Markus Schrettl, Angela M. Cheverton, Carol A. Munro, Dan Chen, Alberto Muñoz, Natalie D. Fedorova, Shinobu Saijo, Louise A. Walker, Timothy C. Cairns, Susanne Herbst, Scott G. Filler, Margherita Bertuzzi, William C. Nierman, Hubertus Haas, Eduardo A. Espeso, Laura Alcazar-Fuoli, Nick D. Read
Publikováno v:
Bertuzzi, M; Schrettl, M; Alcazar-Fuoli, L; Cairns, TC; Muñoz, A; Walker, LA; et al.(2014). The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis. PLoS Pathogens, 10(10). doi: 10.1371/journal.ppat.1004413. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3tv284s0
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS pathogens, vol 10, iss 10
PLoS Pathogens, Vol 10, Iss 10, p e1004413 (2014)
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Pathogens
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 10, no. 10 . https://doi.org/10.1371/journal.ppat.1004413
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 11, no. 6, e1004943 . https://doi.org/10.1371/journal.ppat.1004413
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS pathogens, vol 10, iss 10
PLoS Pathogens, Vol 10, Iss 10, p e1004413 (2014)
Repisalud
Instituto de Salud Carlos III (ISCIII)
PLoS Pathogens
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 10, no. 10 . https://doi.org/10.1371/journal.ppat.1004413
Bertuzzi, M, Schrettl, M, Alcazar-Fuoli, L, Cairns, T C, Muñoz, A, Walker, L A, Herbst, S, Safari, M, Cheverton, A M, Chen, D, Liu, H, Saijo, S, Fedorova, N D, Armstrong-James, D, Munro, C A, Read, N D, Filler, S G, Espeso, E A, Nierman, W C, Haas, H & Bignell, E M 2014, ' The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. ', PL o S Pathogens, vol. 11, no. 6, e1004943 . https://doi.org/10.1371/journal.ppat.1004413
20 p.-8 fig. Margherita Bertuzzi et alt.
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6448d726f776ee22968ded767e73646
http://www.escholarship.org/uc/item/3tv284s0
http://www.escholarship.org/uc/item/3tv284s0
Autor:
Darius Armstrong-James, Yan Yu, Hubertus Haas, Natalie D. Fedorova, Elaine Bignell, Stanley Kim, Ken Haynes, Omar Loss, Dan Chen, Gustavo H. Goldman, Jonathan Crabtree, Andrew McDonagh, Timothy C. Cairns, Markus Schrettl, Gregory S. May, William C. Nierman
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 4, Iss 9, p e1000154 (2008)
PLoS Pathogens, Vol 4, Iss 9, p e1000154 (2008)
Aspergillus fumigatus is a common mould whose spores are a component of the normal airborne flora. Immune dysfunction permits developmental growth of inhaled spores in the human lung causing aspergillosis, a significant threat to human health in the
Autor:
Claudia Kragl, Herbert N. Arst, Markus Schrettl, Omar Loss, Hubertus Haas, Anja Wallner, Yasmin Sabiha, Ken Haynes, Elaine Bignell, Martin Eisendle
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 3, Iss 9, Pp 1195-1207 (2007)
PLoS Pathogens, Vol 3, Iss 9, Pp 1195-1207 (2007)
Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen. We have previously demonstrated that
Autor:
Elaine Bignell, Nick D. Read, Angela M. Cheverton, Darius Armstrong-James, Eduardo A. Espeso, Markus Schrettl, Scott G. Filler, Louise A. Walker, Dan Chen, Susanne Herbst, Carol A. Munro, William C. Nierman, Laura Alcazar-Fuoli, Natalie D. Fedorova, Alberto Muñoz, Timothy C. Cairns, Margherita Bertuzzi, Hong Liu, Hubertus Haas, Shinobu Saijo, Maryam Safari
Publikováno v:
PLoS Pathogens
PLoS pathogens, vol 11, iss 6
PLoS Pathogens, Vol 11, Iss 6, p e1004943 (2015)
e1004943
PLoS pathogens, vol 11, iss 6
PLoS Pathogens, Vol 11, Iss 6, p e1004943 (2015)
e1004943
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal proteases, A. fumigatus mutants lacking indivi