Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ye Chen-Izu"'
Autor:
G. R. Reddy, Ye Chen-Izu, Toni M. West, Qian Shi, Ying Wang, Yang Kevin Xiang, Zhong Jian, Mark Jaradeh
Publikováno v:
The Journal of General Physiology
FRET-based biosensors are powerful tools to study intracellular signaling that require long culture times for adenoviral infection. Reddy et al. have developed a method for culturing adult mouse cardiomyocytes involving blebbistatin, which preserves
Publikováno v:
BIBM
Cardiotoxicity caused by drug candidates and chemical compounds that block hERG channels may lead to malignant ventricular arrhythmias and even sudden cardiac death (SCD). Various in-silico models have been built to predict the cardiotoxicity during
Autor:
Leighton T. Izu, Ye Chen-Izu
Publikováno v:
The Journal of Physiology. 595:3949-3958
The heart has the ability to adjust to changing mechanical loads. The Frank-Starling law and the Anrep effect describe exquisite intrinsic mechanisms the heart has for autoregulating the force of contraction to maintain cardiac output under changes o
Autor:
Katherina M. Alsina, Na Li, Jose L. Puglisi, Donald M. Bers, Xander H.T. Wehrens, Razvan L. Cornea, Hitoshi Uchinoumi, Tetsuro Oda, Ye Chen-Izu, Yi Yang
Publikováno v:
Uchinoumi, H; Yang, Y; Oda, T; Li, N; Alsina, KM; Puglisi, JL; et al.(2016). CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. Journal of Molecular and Cellular Cardiology, 98, 62-72. doi: 10.1016/j.yjmcc.2016.06.007. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9vw6k9jp
© 2016 Elsevier Ltd Diastolic calcium (Ca) leak via cardiac ryanodine receptors (RyR2) can cause arrhythmias and heart failure (HF). Ca/calmodulin (CaM)-dependent kinase II (CaMKII) is upregulated and more active in HF, promoting RyR2-mediated Ca le
Autor:
Ye Chen-Izu, Donald M. Bers
Publikováno v:
The Journal of Physiology. 595:2205-2207
Late Na+ current (INaL) significantly contributes to shaping cardiac action potentials (APs) and increased INaL is associated with cardiac arrhythmias. β-adrenergic receptor (βAR) stimulation and its downstream signaling via protein kinase A (PKA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0892744e07603511862a47e584ed5c
Autor:
Rafael Shimkunas, Kenneth S. Ginsburg, Zana Coulibaly, Kit S. Lam, Leighton T. Izu, Julie Bossuyt, Zhong Jian, Bence Hegyi, Ye Chen-Izu, Donald M. Bers
Publikováno v:
Shimkunas, R; Hegyi, B; Jian, Z; Coulibaly, Z; Lam, KS; Ginsburg, KS; et al.(2017). Mechano-chemo-transduction is attenuated in a rabbit model of heart failure. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 112, 147-147. doi: 10.1016/j.yjmcc.2017.07.052. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/59f771b7
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol 112
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol 112
Author(s): Shimkunas, Rafael; Hegyi, Bence; Jian, Zhong; Coulibaly, Zana; Lam, Kit S; Ginsburg, Kenneth S; Bossuyt, Julie; Bers, Donald M; Izu, Leighton T; Chen-Izu, Ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdb6fea7bf5a12b4a27a10c8f09d5ef
http://www.escholarship.org/uc/item/59f771b7
http://www.escholarship.org/uc/item/59f771b7
Autor:
Xiao-Dong Zhang, Phung N. Thai, Wei Chun Chen, Leighton T. Izu, Ye Chen-Izu, Choong Ryoul Sihn, Maryam Moshref, Hannah A. Ledford, Ebenezer N. Yamoah, Lu Ren, Rafael Shimkunas, Gu Dai, Zhong Jian, Jeong-Han Lee, Hyo Jeong Kim, Padmini Sirish, Maria Valeryevna Timofeyeva, Nipavan Chiamvimonvat, Seojin Park, Valeriy Timofeyev
Publikováno v:
Circulation: Arrhythmia and Electrophysiology. 10
Background Intracellular pH (pH i ) is critical to cardiac excitation and contraction; uncompensated changes in pH i impair cardiac function and trigger arrhythmia. Several ion transporters participate in cardiac pH i regulation. Our previous studies
Publikováno v:
Tissue engineering. Part A, vol 21, iss 5-6
Makris, EA; Huang, BJ; Hu, JC; Chen-Izu, Y; & Athanasiou, KA. (2015). Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage. Tissue Engineering-Part A, 21(5-6), 884-894. doi: 10.1089/ten.tea.2014.0360. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7x6494ng
Makris, EA; Huang, BJ; Hu, JC; Chen-Izu, Y; & Athanasiou, KA. (2015). Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage. Tissue Engineering-Part A, 21(5-6), 884-894. doi: 10.1089/ten.tea.2014.0360. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7x6494ng
© 2015, Mary Ann Liebert, Inc. Toward developing engineered cartilage for the treatment of cartilage defects, achieving relevant functional properties before implantation remains a significant challenge. Various chemical and mechanical stimuli have
Autor:
Ye Chen-Izu
Publikováno v:
Biophysical Journal. 110(3)
The heart can sense and respond to mechanical load in order to maintain adequate blood flow to meet the body's demands for oxygen and fuel. However, intrinsic mechanisms that transduce mechanical stress to biochemical reactions (called mechano-chemo-