Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yazun Jarrar"'
Publikováno v:
Drug Metabolism and Personalized Therapy. 37:149-154
Objectives Increased cholesterol levels were found to be associated with diabetes mellitus type II (DM2). The cholesterol is metabolized by cytochrome 7A1 (CYP7A1) and transported in the intestine by ATP-binding cassette G8 (ABCG8). Genetic variants
Autor:
Qais Jarrar, Mohammad Al Shhab, Yazun Jarrar, Wisam Naser, Malek Zihlif, Abdulla El Madani, Hanin Moh'd Kalloush, Yahya Jamous, Su-Jun Lee, Sara J. Abaalkhail
Publikováno v:
Fundamental & Clinical Pharmacology. 36:143-149
Thiazolidinediones are well-known anti-diabetic drugs. However, they are not widely used due to their cardiotoxic effects. Therefore, in this study, we aimed to determine the molecular toxicological alterations induced in the mouse hearts after thiaz
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:352-359
Background: Endothelial nitric oxide synthase (eNOS) plays a major role in the response of anti-hypercholesterol statin drugs. Genetic polymorphisms in the eNOS gene affect the activity of eNOS thereby modulating the statin response. Objectives: This
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 20:895-902
Background: The Human Leukocyte Antigen (HLA) class II genes, particularly the HLADR and -DQ loci, have been shown to play a crucial role in Type 1 Diabetes (T1D) development. Objective: This study is the first to examine the contribution of the HLA-
Publikováno v:
Annals of Human Genetics. 84:400-411
The objectives of the present study were to identify CYP4V2 genetic variants and characterize their functional consequences. A total of 26CYP4V2 genetic variants were identified, including seven novel variants in 60 randomly selected healthy subjects
Publikováno v:
Biomed Rep
Helicobacter pylori (H. pylori) infection is a global issue. Its eradication in affected individuals is important to prevent several further complications that may occur if left untreated. Proton pump inhibitors (PPIs) serve an important role in the
Autor:
Yazun Jarrar, Raihan Y. Husami, Malek Zihlif, Aya Qteish, Amer Imraish, Farah Tahboub, Su-Jun Lee, Baeth Al-Rawashdeh, Rawand Husami
Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 329, p 329 (2021)
Journal of Personalized Medicine
Volume 11
Issue 5
Journal of Personalized Medicine
Volume 11
Issue 5
Total serum immunoglobulin E (IgE) is elevated in multiple allergic diseases and is considered a good predictor of atopy. Several studies have been performed on the association of IgE levels with the polymorphism of the ADAM33 gene in asthmatic patie
Autor:
Yazun Jarrar, Ismail S. Mahmoud
Publikováno v:
Molecular Biology Reports
The transmembrane protease serine 2 (TMPRSS2) is a membrane anchored protease that primarily expressed by epithelial cells of respiratory and gastrointestinal systems and has been linked to multiple pathological processes in humans including tumor gr
Autor:
Yazun Jarrar, Rana Dajani, Malek Zihlif, Ahmad M. Saleh, Sara Abudahab, Nancy Hakooz, Mohammad Al Shahhab
Publikováno v:
Current Drug Metabolism. 20:399-410
Background:Glucuronidation is one of the most important phase II metabolic pathways. It is catalyzed by a family of UDP-glucuronosyltransferase enzymes (UGTs). UGT1A1 and UGT1A7 catalyze the glucuronidation of a diverse range of medications, environm
Autor:
Yazun Jarrar, Maria Ghishan
Publikováno v:
Asian Pacific Journal of Cancer Prevention : APJCP
Background: Nudix Hydrolase 15 gene (NUDT15) encodes nucleotide triphosphate diphosphatase which metabolizes the purine analog drugs, such as anticancer thiopurine and anti-gout allopurinol. Genetic variants on Nudix Hydrolase 15 gene (NUDT15) gene e