Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Yassine Amrani"'
Autor:
Aamir Hussain, Fahad Alhadian, Peter Bradding, Omar Tliba, Yassine Amrani, Abdulrahman Alzahrani, Jameel Hakeem, Sana Douaoui
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030630454
The mechanisms driving corticosteroid insensitivity in asthma are still unclear although evidence points toward a potential role of lung mast cells. Indeed, a number of in vitro studies using various cell types showed that different mediators produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1228dcc6f4009e6f9d0ef6306de8170a
https://doi.org/10.1007/978-3-030-63046-1_1
https://doi.org/10.1007/978-3-030-63046-1_1
Publikováno v:
Airway cell biology and immunopathology.
Asthma is complex condition involving multiple cell types and populations. Understanding how these inflammatory cells distribute and interact in the disease state still unknown. Identifying the cell types present or the therapeutic target of interest
Autor:
Peter Bradding, Yassine Amrani, Christopher E. Brightling, Katherine Clark, Katy M. Roach, Panayiota Stylianou, Dawn T. Smallwood, Bibek Gooptu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Chronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in the TNS1 gene, whi
Publikováno v:
Allergy and immunology.
Introduction: Compared to lean patients, obese asthmatic patients suffer from severe symptoms, frequent exacerbations, poor quality of life and poor response to corticosteroids. Very little is known about the mechanisms by which obesity affects asthm
Publikováno v:
Immunobiology
Airway remodeling in asthma manifests, in part, as enhanced airway smooth muscle (ASM) mass, due to myocyte proliferation. While the anti-proliferative effects of glucocorticoid (GC) were investigated in normal ASM cells (NASMC), little is known abou
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:728-737
Preclinical models of human conditions including asthma showed the therapeutic potential of Compound A (CpdA), a dissociated glucocorticoid (GC) receptor (GRα) ligand. Whether CpdA inhibits GC resistance, a central feature of severe asthma, has not
Autor:
Peter Bradding, Latifa Chachi, Yassine Amrani, Reynold A. Panettieri, Cynthia Koziol-White, Abdulrahman Alzahrani, Michael Biddle, Rehab Bagadood
Publikováno v:
Clinical and experimental immunology. 194(2)
Summary The purpose of this study was to investigate whether growth factors produced by activated human lung mast cells (HLMCs) impair β2-adrenoceptor (β2-AR) function in human airway smooth muscle (ASM) cells. Protein array analysis confirmed the
Autor:
John David Ganther, Alaa Khatib, Omar Tliba, Blerina Kokalari, Danielle O'Connell, Belaid Bouazza, Yassine Amrani
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 309:L348-L359
Although the majority of patients with asthma are well controlled by inhaled glucocorticoids (GCs), patients with severe asthma are poorly responsive to GCs. This latter group is responsible for a disproportionate share of health care costs associate
Autor:
Lauren Isaacs, Omar Tliba, Belaid Bouazza, Yassine Amrani, Danielle Formella, Danielle O'Connell, Sara Ahamed, Manel Debba-Pavard
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 50:301-315
Like many steroid receptors, the glucocorticoid (GC) receptor (GR) is a phosphoprotein. Although there are multiple phosphorylation sites critical for GR transcriptional activity (i.e., serine [S]203, S211, and S226), their respective role in driving
Autor:
Latifa Chachi, Omar Tliba, Christopher E. Brightling, S. Mark Duffy, Yassine Amrani, Aarti Shikotra, Peter Bradding
Publikováno v:
The Journal of Immunology. 191:2624-2636
Identifying the factors responsible for relative glucocorticosteroid (GC) resistance present in patients with severe asthma and finding tools to reverse it are of paramount importance. In asthma we see in vivo evidence of GC-resistant pathways in air