Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Weihong Song"'
Autor:
Meng Chen, Weihong Song, Zhongding Li, Dirk Schlüter, Jing Ruan, Gloria M. Manjengwa, Xu Wang, Baohua Liu
Publikováno v:
Molecular Psychiatry. 27:259-268
Neurodegenerative diseases (NDs) are characterized by the aggregation of neurotoxic proteins in the central nervous system. Aberrant protein accumulation in NDs is largely caused by the dysfunction of the two principal protein catabolism pathways, th
Autor:
Wei-Wei Li, Jin-Tai Yu, Li-Yong Chen, Wei Xu, Wang-Sheng Jin, Chi Zhu, Yang Xiang, Xiaowei Chen, Zhiming Zhu, Zhian Hu, Xian-Le Bu, Hua-Dong Zhou, Jun Wang, Zhen Wang, Ding-Yuan Tian, Gui-Hua Zeng, Bin-Lu Sun, Yan-Jiang Wang, Yu-Hui Liu, Lin-Lin Shen, Weihong Song
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Translational Psychiatry
Translational Psychiatry
Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the AD intervention from treatment to preven
Publikováno v:
Neurochemical Research. 45:2113-2127
The abnormally accumulated amyloid-β (Aβ) and oxidative stress contribute to the initiation and progression of Alzheimer's disease (AD). β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme for the production of A
Autor:
Juelu Wang, Mingjing Liu, Daochao Huang, Xing Nie, Weihong Song, Dandan Lou, Yu Kang, Yanhua Li, Shipeng Guo, Isabel Bestard Lorigados, Weihui Zhou, Shou Yang
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-12 (2019)
Molecular Brain
Molecular Brain
Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely unknown. To study the mechanism underlyingUSP16gene expression,USP16gene promoter
Autor:
Junjie Yan, Limin Zhang, Qingqing Xu, Pengtao Xu, Hongchang Gao, Chen Li, Weihong Song, Xi Zhang, Hui Ji, Qiaoying Jiang, Yuping Li, Hong Zheng, Xiaokun Li, Jie Ning, Yafei Zheng
Publikováno v:
Microbiome
Microbiome, Vol 9, Iss 1, Pp 1-19 (2021)
Microbiome, Vol 9, Iss 1, Pp 1-19 (2021)
BackgroundModification of the gut microbiota has been reported to reduce the incidence of type 1 diabetes mellitus (T1D). We hypothesized that the gut microbiota shifts might also have an effect on cognitive functions in T1D. Herein we used a non-abs
Autor:
Weihong Song, Yannan Liu, Yun Zhang, Dan Wang, Rong Hu, Weihui Zhou, Zijun Meng, Dongjie Hu, Huan Yang, Mingjing Liu, Qunxian Wang
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-11 (2021)
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-11 (2021)
Increased endogenous hydrogen sulfide (H2S) level by cystathionine β-synthase (CBS) has been shown to closely relate tumorigenesis. H2S promotes angiogenesis, stimulates bioenergy metabolism and inhibits selective phosphatases. However, the role of
Autor:
Michael X. Zhu, Haiyang Tong, Yihui Guan, Shajin Huang, Donglang Jiang, Yun Zhang, Ting Qian, Xiaoli Pan, Shaoming Sang, Weihong Song, Fang Cai, Qing Zhang, Yangqi Xu, Yun Wu, Xiang Yu, Chunjiu Zhong, Changpeng Wang, Xiaoqin Cheng, Hongyan Qiu, Kai Zhong
BackgroundThiamine diphosphate (TDP) reduction plays an important role in cerebral glucose hypometabolism, the neurodegenerative indicator, in Alzheimer’s disease (AD). The mechanism underlying TDP reduction remains elusive. Thus, it is critical to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce9d79c2cd7c6efe5dac5f3051da3f6e
https://doi.org/10.1101/2020.06.09.141358
https://doi.org/10.1101/2020.06.09.141358
Autor:
Yafang Zhou, Fang Cai, Xinxiang Yan, Lina Guo, Xinxin Liao, Hong Jiang, Jiada Li, Yun Zhang, Xixi Liu, Bin Jiao, Jifeng Guo, Kun Xia, Lu Shen, Juelu Wang, Junling Wang, Jinchen Li, Zhanfang Sun, Beisha Tang, Weihong Song
Accumulation of amyloid β protein (Aβ) due to increased generation and/or impaired degradation plays an important role in Alzheimer's disease (AD) pathogenesis. In this report, we describe the identification of rare coding mutations in the endothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d2db0cd447a4d1da5e1a3ed97318a6
https://europepmc.org/articles/PMC7101146/
https://europepmc.org/articles/PMC7101146/
Autor:
Fang Cai, Rong Hu, Yun Zhang, Dongjie Hu, Mingjing Liu, Weihui Zhou, Zijun Meng, Zhichao Guo, Yannan Liu, Dan Wang, Weihong Song, Qunxian Wang, Huan Yang
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 2, Pp n/a-n/a (2020)
Molecular Genetics & Genomic Medicine, Vol 8, Iss 2, Pp n/a-n/a (2020)
Background Wieacker‐Wolff syndrome (WWS) is a congenital X‐linked neuromuscular disorder, which was firstly reported in 1985. Zinc finger C4H2‐type containing (ZC4H2) gene has been found to be associated with the disease pathogenesis. However,
Autor:
Lu Shen, Tahereh Bozorgmehr, Daochao Huang, Jifeng Guo, Yili Wu, Catharine H. Rankin, Si Zhang, Beisha Tang, Zhe Wang, Fang Cai, Weihong Song, Shuting Zhang
Publikováno v:
Molecular Psychiatry. 25:603-613
Presenilin-1 (PSEN1) is the catalytic subunit of the γ-secretase complex, and pathogenic mutations in the PSEN1 gene account for the majority cases of familial AD (FAD). FAD-associated mutant PSEN1 proteins have been shown to affect APP processing a