Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Toshiyuki Takehara"'
Autor:
Tatsufumi Mori, Toshiyuki Takehara, Kanji Fukuda, Yuta Onodera, Takeshi Teramura, Kayoko Obora
Publikováno v:
Aging Cell
Summary Inflammation-induced reactive oxygen species (ROS) are implicated in cellular dysfunction and an important trigger for aging- or disease-related tissue degeneration. Inflammation-induced ROS in stem cells lead to deterioration of their proper
Autor:
Maki Itokazu, Toshiyuki Takehara, Tatsufumi Mori, Takeshi Teramura, Yuta Onodera, Kanji Fukuda
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204860 (2018)
PLoS ONE
PLoS ONE
Tissue renewal and muscle regeneration largely rely on the proliferation and differentiation of muscle stem cells called muscular satellite cells (MuSCs). MuSCs are normally quiescent, but they are activated in response to various stimuli, such as in
Autor:
Akane Kizu, Kohei Kitada, Shoji Fukushima, Masayasu Koyama, Daisuke Tachibana, Toshiyuki Takehara, Hideki Wanibuchi, Takashi Morita, Kayo Yoshida, Masami Hayashi, Takeshi Teramura
Publikováno v:
Environmental Science and Pollution Research. 22:18252-18259
A high-throughput test of cell growth inhibition was performed using mouse embryonic stem (ES) cells to assess chemical toxicities. We herein demonstrated using a 96-well culture plate approach and the MTT assay that this method was suitable for prio
Autor:
Yuta Onodera, Joe Hasei, Toshifumi Ozaki, Takeshi Teramura, Kanji Fukuda, Toshiyuki Takehara, John P. Frampton, Kayoko Obora
Publikováno v:
Scientific Reports
Intracerebral inflammation resulting from injury or disease is implicated in disruption of neural regeneration and may lead to irreversible neuronal dysfunction. Analysis of inflammation-related microRNA profiles in various tissues, including the bra
Autor:
Yuta Kida, Yuta Onodera, John P. Frampton, Yoshihiko Hosoi, Takeshi Teramura, Naoto Fukunaga, Hiroki Izumi, Hironobu Sugimoto, Kanji Fukuda, Makiko Kawakami, Toshiyuki Takehara, Miho Nakano
Publikováno v:
Stem Cells and Development. 22:928-938
In mammalian ovaries, many immature follicles remain after the dominant follicles undergo ovulation. Here we report the successful production of rabbit embryonic stem cells (ESCs) from oocytes produced by in vitro culture of immature follicles and su
Autor:
Kanji Fukuda, John P. Frampton, Yoshihisa Miki, Toshiyuki Takehara, Yoshihiko Hosoi, Koichi Nakagawa, Chiaki Hamanishi, Syunsuke Ito, Toshiki Matsuoka, Takeshi Teramura, Yuta Onodera
Publikováno v:
Cell Transplantation, Vol 22 (2013)
Embryonic stem cells (ESCs) have the potential to be used as an unlimited cell source for cell transplantation therapy, as well as for studying mechanisms of disease and early mammalian development. However, applications involving ESCs have been limi
Publikováno v:
Stem Cells and Development. 21:1239-1249
Recently, an additional type of pluripotent stem cell-line derived from mouse embryos has been established and termed epiblast stem cell (EpiSC), and is expected to be an important tool for studying the mechanisms of maintenance of pluripotency since
Autor:
Toshiyuki Takehara, Takeshi Teramura, Chiaki Hamanishi, Koichi Nakagawa, Yuta Onodera, Kanji Fukuda
Publikováno v:
Biochemical and Biophysical Research Communications. 417:836-841
Mechanical stimulation has been shown to regulate the proliferation and differentiation of stem cells. However, the effects of the mechanical stress on the stemness or related molecular mechanisms have not been well determined. Pluripotent stem cells
Autor:
Toshihiro Mihara, Yoshihiko Hosoi, Kanji Fukuda, Toshiyuki Takehara, Tasuku Mitani, Kazuhiro Saeki, Syunsuke Ito, Kazuya Matsumoto, Norimasa Sagawa, Takeshi Teramura, Hiromi Kato, Masayuki Anzai, Hideki Murakami, Yuta Onodera
Publikováno v:
Journal of Reproduction and Development. 55:283-292
The embryos of some rodents and primates can precede early development without the process of fertilization; however, they cease to develop after implantation because of restricted expressions of imprinting genes. Asexually developed embryos are clas
Autor:
Makoto Takenoshita, Toshiyuki Takehara, Kanji Fukuda, Yuta Onodera, Yoshihiko Hosoi, Takeshi Teramura, Naoto Fukunaga, Norimasa Sagawa, Ryo Kakegawa
Publikováno v:
Molecular Human Reproduction
Non-human primates are suitable models for preclinical research aimed at cell-replacement therapies. Recently, it has been reported that Rho-associated kinase inhibitor Y-27632 markedly reduced dissociation-induced apoptosis of human embryonic stem (