Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Theresa Proia"'
Autor:
A. Hughes, Patricia McCoon, Stephen Fawell, Gayathri Bommakanti, Simon T. Barry, Deanna A. Mele, Larissa S. Carnevalli, Christopher Womack, Michael Collins, Nanhua Deng, Lukasz Magiera, Mingchao Xie, J. Carl Barrett, Richard Woessner, Srimathi S. Srinivasan, Deanna L. Russell, Shaun E Grosskurth, Corinne Reimer, Maneesh Singh, Minwei Ye, Theresa Proia, Matthew Griffin, Susan Cantin
Publikováno v:
Clinical Cancer Research. 26:6335-6349
Purpose: Danvatirsen is a therapeutic antisense oligonucleotide (ASO) that selectively targets STAT3 and has shown clinical activity in two phase I clinical studies. We interrogated the clinical mechanism of action using danvatirsen-treated patient s
Autor:
Dallin Milner, Jason S. Williams, Karyn A. Goodman, Michael J. Gough, Thomas E. Bickett, Wells A. Messersmith, Benjamin Van Court, Eric T. Clambey, Theresa Proia, Kimberly R. Jordan, Sana D. Karam, Richard D. Schulick, Ayman Oweida, Shilpa Bhatia, Andy Phan, Kirk C. Hansen, Miles Piper, Adam C. Mueller, Marco Del Chiaro
Publikováno v:
Cancer Immunology, Immunotherapy. 70:989-1000
Pancreatic ductal adenocarcinoma (PDAC) has a heterogeneous tumor microenvironment (TME) comprised of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages, neutrophils, regulatory T cells, and myofibroblasts. The precise mechanisms
Autor:
Yanjun Wang, Sigourney Bell, A. Hughes, Theresa Proia, Neha Wali, Pablo Morentin Gutierrez, Matthew A. King, Larissa S. Carnevalli, Molly A. Taylor, Danielle Carroll, Michele Moschetta, Maneesh Singh, Antonio Ramos-Montoya, Cristina Gardelli, Stephen Fawell, Simon T. Barry, Anna M. L. Coenen-Stass, Teresa Klinowska, Susan E. Critchlow
Publikováno v:
Molecular cancer therapeutics. 20(6)
Suppressive myeloid cells mediate resistance to immune checkpoint blockade. PI3Kγ inhibition can target suppressive macrophages, and enhance efficacy of immune checkpoint inhibitors. However, how PI3Kγ inhibitors function in different tumor microen
Autor:
Noel R. Monks, Maryann San Martin, Corinne Reimer, Griffin Matthew, Maneesh Singh, Lisa Drew, Laura Bradshaw, Theresa Proia, Simon T. Barry, Laura Prickett
Publikováno v:
Cancer Research. 81:1813-1813
The complex interplay between the immune system and cancer cells is challenging to model in preclinical species. Many commonly mutated genes that influence tumorigenesis actively participate in the activation, recruitment or suppression of the immune
Autor:
Horma Ghadially, Kristina M. Ilieva, Scott Mlynarski, Alwin Schuller, Theresa Proia, Wenlin Shao, Eric Gangl, Sharon Tentarelli, Aatman Doshi, Susan Cantin, Michael Secinaro, Yanjun Wang, Laura Prickett, Ray Finlay
Publikováno v:
Cancer Research. 80:4523-4523
The tumor microenvironment (TME) has multiple mechanisms of immune-suppression, one being recruitment of arginase (ARG) expressing myeloid cells. ARG is an enzyme that catalyzes hydrolysis of L-arginine into urea and L-ornithine. L-arginine is a semi
Publikováno v:
Cancer Research. 78:306-306
Cyclin-dependent kinase 9 (CDK9) regulates transcription elongation through phosphorylation of RNA polymerase II at serine 2 (pSer2-RNAPII), and its short-term inhibition downregulates genes with short-lived transcripts and labile proteins, thus prov
Autor:
Lisa Drew, Douglas Ferguson, Scott Boiko, Theresa Proia, Justin Cidado, Steven Criscione, Maryann San Martin, Wenlin Shao
Publikováno v:
Cancer Research. 78:310-310
Cyclin-dependent kinase 9 (CDK9) regulates elongation of transcription through phosphorylation of RNA polymerase II (pSer2-RNAPII), and its short-term inhibition downregulates genes with short-lived transcripts and labile proteins. We developed a nov
Autor:
Lisa Drew, Barlaam Bernard Christophe, Janet Hawkins, Jeff Varnes, Alexander Hird, Nichole O'Connell, Theresa Proia, Maryann San Martin, Douglas Ferguson, Melissa Vasbinder, Andrew D. Ferguson, Kurt Gordon Pike, Chungang Gu, Wenlin Shao, Jianyan Wang, Chris De Savi, Michelle Lamb
Publikováno v:
Cancer Research. 78:1650-1650
Cyclin-dependent kinase 9 (CDK9) is a serine/threonine kinase that regulates elongation of transcription through phosphorylation of RNA polymerase II at serine 2 (p-Ser2-RNAPII). Transient inhibition of CDK9 results in reduced protein levels for gene
Autor:
Ricky W. Johnstone, Justin Cidado, Lisa Drew, Gareth P. Gregory, Theresa Proia, Scott Boiko, Maryann San Martin, Izabela Todorovski
Publikováno v:
Cancer Research. 77:4295-4295
Cyclin-dependent kinase 9 (Cdk9) is a serine/threonine kinase that regulates elongation of transcription through phosphorylation of RNA polymerase II at serine 2 (pSer2-RNAPII). Transient inhibition of Cdk9 results in modulation of genes with short-l
Autor:
Theresa Proia, Nanhua Deng, Vasu R. Sah, Deborah Lawson, Maryann San Martin, Sabina Cosulich, Corinne Reimer, Urzsula Polanska
Publikováno v:
Molecular Cancer Therapeutics. 14:B112-B112
Diffuse large B cell lymphoma (DLBCL) is the most common type of aggressive non Hodgkins lymphoma. The Activated B-Cell (ABC) subtype of DLBCL is driven by chronic active BCR signaling and remains the most difficult to treat. Resistant ABC-DLBCL occu