Zobrazeno 1 - 10
of 38
pro vyhledávání: '"TAKASHI HIRAI"'
Publikováno v:
Journal of Visualized Experiments.
Immune checkpoint inhibitors, including PD-1-blocking antibodies, have significantly improved treatment outcomes in various types of cancer. The pharmacological efficacy of these immunotherapies is long lasting, extending even beyond the discontinuat
Autor:
Masato Yuasa, Toshitaka Yoshii, Takashi Hirai, Yutaka Kobayashi, Hoashi Numata, Hiroyuki Inose, Mieradili Mulati, Takahashi Akira, Shingo Sato, Yoichi Ezura, Yuichi Hiraoka, Hiroki Ochi, Masanori Saito, Atsushi Okawa
Publikováno v:
Bone. 130:115076
In the past decade, a growing importance has been placed on understanding the significance of long noncoding RNAs (lncRNAs) in regulating development, metabolism, and homeostasis. Osteoblast proliferation and differentiation are essential elements in
Autor:
Ichiro Nishimura, Takashi Hirai, Yanbing Cheng, Yatendra Mulpuri, Supanigar Ruangsri, Wei Li, Zheng Xia, Igor Spigelman
Publikováno v:
Scientific reports, vol 7, iss 1
Scientific Reports
Hirai, T; Mulpuri, Y; Cheng, Y; Xia, Z; Li, W; Ruangsri, S; et al.(2017). Aberrant plasticity of peripheral sensory axons in a painful neuropathy. SCIENTIFIC REPORTS, 7. doi: 10.1038/s41598-017-03390-9. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0141f3gj
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Hirai, T; Mulpuri, Y; Cheng, Y; Xia, Z; Li, W; Ruangsri, S; et al.(2017). Aberrant plasticity of peripheral sensory axons in a painful neuropathy. SCIENTIFIC REPORTS, 7. doi: 10.1038/s41598-017-03390-9. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0141f3gj
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Neuronal cells express considerable plasticity responding to environmental cues, in part, through subcellular mRNA regulation. Here we report on the extensive changes in distribution of mRNAs in the cell body and axon compartments of peripheral senso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174eb6db78998d4298be5ff313912535
https://escholarship.org/uc/item/0141f3gj
https://escholarship.org/uc/item/0141f3gj
Publikováno v:
Methods in Molecular Biology ISBN: 9781493931118
RNA interference is a powerful tool used to induce loss-of-function phenotypes through post-transcriptional gene silencing. Small interfering RNA (siRNA) molecules have been used to target the central nervous system (CNS) and are expected to have cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2efe43b6d836473d9549a15b074712e
https://doi.org/10.1007/978-1-4939-3112-5_22
https://doi.org/10.1007/978-1-4939-3112-5_22
Autor:
Kenichi Shinomiya, Hiroya Kuwahara, Shinichi Sotome, Atsushi Okawa, Takanori Yokota, Takashi Hirai, Hidehiro Mizusawa, Mio Tajiri, Yukihiko Hirai, Akira Machida, Mitsuhiro Enomoto, Mariko Yamamoto
Publikováno v:
Human Gene Therapy Methods. 23:119-127
Gene therapy for neurological diseases requires efficient gene delivery to target tissues in the central and peripheral nervous systems. Although adeno-associated virus is one of the most promising vectors for clinical use against neurological diseas
Autor:
Makiko Fujii, Ichiro Takeuchi, Hidemi Ito, Tsuyoshi Sano, Takashi Hirai, Yutaka Kondo, Keiko Shinjo, Yoshitaka Sekido, Masahiro Tajika, Koji Komori, Yukihide Kanemitsu, Akira Sawaki, Hai Xing Ju, Hideki Murakami, Hirotaka Osada, Yasuyuki Okamoto, Yasuhiro Shimizu, Byonggu An, Kenji Yamao
Publikováno v:
The American Journal of Pathology. 178:1835-1846
Liver metastasis is a fatal step in the progression of colorectal cancer (CRC); however, the epigenetic evolution of this process is largely unknown. To decipher the epigenetic alterations during the development of liver metastasis, the DNA methylati
Autor:
Kazuo Kusano, Shigeo Okabe, Atsushi Okawa, Shizuko Ichinose, Kenichi Shinomiya, Soichiro Itoh, Mitsuhiro Enomoto, Yoshiaki Wakabayashi, Takashi Hirai
Publikováno v:
Neuroscience Letters. 492:64-69
It is known that Rho family small GTPases activate a number of signal transduction pathways involved in cell cycle progression, gene expression, and cell survival. These small G proteins play an important role in neuronal survival and axon regenerati
Autor:
Akira Sawaki, Yoshitaka Sekido, Hideki Murakami, Byonggu An, Hirotaka Osada, Jean Pierre J. Issa, Yukihide Kanemitsu, Lanlan Shen, Koji Komori, Makiko Fujii, Yasuyuki Okamoto, Takashi Hirai, Tsuneya Nakamura, Tohru Tani, Kenji Yamao, Keitaro Matsuo, Masahiro Tajika, Keiko Shinjo, Yutaka Kondo, Yasushi Yatabe
Publikováno v:
International Journal of Cancer. 127:2095-2105
Aberrant DNA methylation is involved in colon carcinogenesis. Although the CpG island methylator phenotype (CIMP) is defined as a subset of colorectal cancers (CRCs) with remarkably high levels of DNA methylation, it is not known whether epigenetic p
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 337:180-184
UV irradiation of a Malachite Green leuconitrile derivative, solubilized in the organic phase of a chloroform/1-hexanol/aqueous mixture, affords a cationic surfactant. These surfactant molecules associate more readily than do the parent molecules to
Publikováno v:
Diseases of the Colon & Rectum. 51:1675-1680
This study was designed to determine the efficacy of carcinoembryonic antigen (CEA) monitoring for screening patients with colorectal cancer by using posttest probability of recurrence.For this study, 348 (preoperative serum CEA level elevated: CEA+,