Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sven Möbius-Winkler"'
Autor:
Christian Jung, Alexander Pfeil, Sven Möbius-Winkler, Julian Westphal, P. Christian Schulze, Katja Grün, Gudrun Dannberg, Laura Bäz, Marcus Franz
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 11
International Journal of Molecular Sciences, Vol 21, Iss 4174, p 4174 (2020)
Volume 21
Issue 11
International Journal of Molecular Sciences, Vol 21, Iss 4174, p 4174 (2020)
In patients with aortic stenosis (AS), a novel staging classification of extra-valvular left and right heart damage with prognostic relevance was introduced in 2017. The aim of the study was to evaluate the biomarkers of cardiovascular tissue remodel
Autor:
Danielle L. Brunjes, Peter J. Kennel, Ruiping Ji, Konstantinos Drosatos, Estibaliz Castillero, Sven Möbius-Winkler, Emily I. Chen, P. Christian Schulze, Xiaokan Zhang, Xianghai Liao, Marcus Franz, Isaac George, Paolo C. Colombo
Publikováno v:
Circulation. 137(19)
Background: Heart failure leads to mitochondrial dysfunction and metabolic abnormalities of the failing myocardium coupled with an energy-depleted state and cardiac remodeling. The mitochondrial deacetylase sirtuin 3 (SIRT3) plays a pivotal role in t
Autor:
Sven Möbius-Winkler, Volker Adams, Andrej Teren, Karla Punkt, Gerhard Schuler, Yasuharu Matsumoto, Norman Mangner, Axel Linke, Katharina Kackstein
Publikováno v:
Acta Histochemica. 115:363-370
Activation of the renin-angiotensin-aldosterone system and increased levels of angiotensin II (Ang-II) occurs in numerous cardiovascular diseases such as chronic heart failure (CHF). Another hallmark in CHF is a reduced exercise tolerance with impair
New familial heterozygous c 4066_4068 delTT 2 bp deletion of the SCN5A gene causing Brugada syndrome
Publikováno v:
Heart Rhythm. 8:1224-1227
Background Cardiac sodium channel alterations have been identified as the underlying condition in patients with Brugada syndrome. Objective This study identified a novel mutation of the SCN5A gene in a family with Brugada syndrome. Methods Blood was
Autor:
Volker Adams, Ephraim B Beck, Robert Höllriegel, Gerhard Schuler, Sven Möbius Winkler, Marcus Sandri, Sandra Erbs, Stephan Gielen, Rainer Hambrecht, Karsten Lenk, Axel Linke
Publikováno v:
European Journal of Preventive Cardiology. 19:404-411
Background: In chronic heart failure (CHF), cardiac cachexia is often associated with the terminal stage of this disease. In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stag
Autor:
Gerhard Schuler, Axel Linke, Eduard Fiehn, Sven Möbius-Winkler, Volker Adams, Sandra Erbs, Andreas Schubert, Stephan Gielen, Rainer Hambrecht, Paul Christian Schulze
Publikováno v:
Circulation. 111:1763-1770
Background— In chronic heart failure (CHF), cross-talk between inflammatory activation and oxidative stress has been anticipated in skeletal muscle (SM). The role of the radical scavenger enzymes superoxide dismutase (SOD), catalase (Cat), and glut
Autor:
Sven Möbius-Winkler, Rainer Hambrecht, Stephan Gielen, Sandra Erbs, P. Christian Schulze, Volker Adams, Axel Linke, Jürgen Kratzsch, Gerhard Schuler
Publikováno v:
Basic Research in Cardiology. 98:267-274
Objective: Chronic heart failure (CHF) is associated with metabolic abnormalities leading to a catabolic syndrome in advanced stages of the disease. To assess the role of proinflammatory cytokines for the local expression of insulin-like growth facto
Autor:
Eduard Fiehn, Gerhard Schuler, Jiangtao Yu, Rainer Hambrecht, Josef Niebauer, Sven Möbius-Winkler, Volker Adams, Axel Linke, Stephan Gielen, Hong Jiang
Publikováno v:
Journal of the American College of Cardiology. 33:174-179
This study was designed to analyze the effect of iNOS on mitochondrial creatine kinase (mi-CK) expression and exercise capacity in chronic heart failure (CHF).The molecular mechanisms underlying exercise intolerance in CHF are still unclear. Expressi
Autor:
Gerhard Schuler, Rainer Hambrecht, Volker Adams, Lutz Hilbrich, Jiangtao Yu, Sven Möbius-Winkler, Claudia Weigl, Axel Linke
Publikováno v:
Biochemical and Molecular Medicine. 61:152-160
In addition to left ventricular pump failure and low cardiac output, structural and metabolic alterations of skeletal muscle are thought to contribute to exercise intolerance seen in patients with CHF. Studies using cardiac myocytes have implicated n
Publikováno v:
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on EpidemiologyPrevention and Cardiac Rehabilitation and Exercise Physiology. 16