Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Susan V. Hughes"'
Autor:
Cedric H. L. Shackleton, Susan V. Hughes, Beverly A. Hughes, Peter Nightingale, Paul M. Stewart, Nicola Crabtree, Theresa McCarthy, Rachel K Crowley, Joanna Gray, Jeremy W. Tomlinson
Publikováno v:
Europe PubMed Central
ObjectiveDysregulation of enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistance; however, longitudinal changes in glucocorticoid metabolism have not been investigated. This stud
Autor:
Susan V. Hughes, William Carley, Fiona Kilvington, Jeremy W. Tomlinson, Beverley Hughes, Paul M. Stewart, Rachel Courtney, William A. Bartlett, Mark Sherlock, Paul A. Rejto
Publikováno v:
J Clin Endocrinol Metab
Context: The pathophysiological importance of glucocorticoids (GCs) is exemplified by patients with Cushing’s syndrome who develop hypertension, obesity, and insulin resistance. At a cellular level, availability of GCs to the glucocorticoid and min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07320cd431347a430e3e3462e8255f7
https://ora.ox.ac.uk/objects/uuid:8af5a540-4c6f-459f-b8e0-c250aadde678
https://ora.ox.ac.uk/objects/uuid:8af5a540-4c6f-459f-b8e0-c250aadde678
Publikováno v:
Diabetes
OBJECTIVE—The epidemics of obesity, insulin resistance, and type 2 diabetes have heightened the need to understand mechanisms that contribute to their pathogenesis. Increased endogenous glucocorticoid production has been implicated based on paralle
Autor:
Paul M. Stewart, Marcus Quinkler, Sabine Buhner, Susan V. Hughes, Martin Hewison, Bruno Allolio, Kirren Kaur, Iwona J. Bujalska, Claire Onyimba
Publikováno v:
Hypertension. 46:787-798
Rodents studies suggest that androgens are involved in sex-specific differences in blood pressure. In humans, there is no difference in blood pressure between boys and girls, but after puberty, blood pressure increases more in men than in women. We i
Autor:
Lisa M. Freeman, Ronjon Chakraverty, Katie N. Evans, Susan V. Hughes, Deborah Hardie, Terry K. Means, Martin Hewison
Publikováno v:
Blood. 106:2042-2049
Glucocorticoids (GCs) exert powerful anti-inflammatory effects that may relate in part to their ability to restrict the differentiation and function of dendritic cells (DCs). Although these inhibitory effects are dependent upon GCs binding to nuclear
Autor:
Susan V. Hughes, Martin Hewison, Rosemary Bland, Susan L.F. Chan, Paul E. Squires, Claire E. Hills, Danijela Markovic
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. :121-125
A number of studies have suggested that Vitamin D has a potential role in the development/treatment of diabetes. These effects may be mediated by circulating levels of 1alpha,25(OH)(2)D(3), but local production of 1alpha,25(OH)(2)D(3), catalysed by t
Autor:
Rosemary Bland, Lisa M. Freeman, Katie N. Evans, Aristides G. Eliopoulos, Ronjon Chakraverty, Susan V. Hughes, Paul Moss, Mark D. Kilby, Martin Hewison
Publikováno v:
The Journal of Immunology. 170:5382-5390
The functions of dendritic cells (DCs) are tightly regulated such that protective immune responses are elicited and unwanted immune responses are prevented. 1 alpha 25-dihydroxyvitamin D(3) (1 alpha 25(OH)(2)D(3)) has been identified as a major facto
Autor:
Paul Stewart, Beverly A. Hughes, Jeremy Tomlinson, Susan V. Hughes, Rachel K Crowley, Cedric H.L. Shackleton, Peter Nightingale, Joanna Gray, Theresa McCarthy, Nicola Crabtree
Publikováno v:
Endocrine Abstracts.
Autor:
L.J. Eyre, Paul M. Stewart, Martin Hewison, Susan V. Hughes, Rosemary Bland, Mark S. Cooper, Michael C. Sheppard, Elizabeth H. Rabbitt
Publikováno v:
Journal of Cellular Biochemistry. 81:453-462
11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) acts as a pre-receptor signaling mechanism for corticosteroids by regulating the access of active glucocorticoids to both glucocorticoid (GR) and mineralocorticoid receptors (MR). To examine the rela
Publikováno v:
British Journal of Cancer
Epidemiological data suggest that oestrogen contributes to the aetiology of colonic cancer. Furthermore, recent studies have suggested that local hormone metabolism may play a key role in determining colonic responsiveness to oestrogen. To further cl