Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Suidong Ouyang"'
Autor:
Hua Jin, Jiale Li, Miaoyuan Zhang, Renxing Luo, Peishan Lu, Wenting Zhang, Junai Zhang, Jiang Pi, Weixin Zheng, Zesen Mai, Xiaowen Ding, Xinguang Liu, Suidong Ouyang, Gonghua Huang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it is very important to develop effective therapeutics
Autor:
Jodi L. Bubenik, Xing Chen, Donny D. Licatalosi, Kommireddy Vasu, Hui Yang, Tomasz Herjan, Xiao Li, Caini Liu, Xiaoxia Li, Katarzyna Bulek, Wen Qian, Suidong Ouyang, Jun Qin, Kewal Asosingh, Paul L. Fox, Lingzi Hong, Eric Cockman, Thomas A. Hamilton, Junjie Zhao, Mark A. Aronica, Donna M. Driscoll, Hao Zhou
Publikováno v:
Nature Immunology. 19:354-365
Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-complex adaptor, binds and stabilizes mRNAs encoding key inflammatory protei
Publikováno v:
Brain, Behavior, and Immunity. 40:61-73
Leptin, a pleiotropic adipokine, crosses the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) from the periphery and facilitates experimental autoimmune encephalomyelitis (EAE). EAE induces dynamic changes of leptin receptors in enriche
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 34:43-51
The blood–brain barrier (BBB) is a regulatory interface between the central nervous system and the rest of the body. However, BBB changes in obesity and metabolic syndrome have not been fully elucidated. We hypothesized that obesity reduces energy
Publikováno v:
Journal of Cellular Physiology. 228:1610-1616
Hyperleptinemia is usually associated with obesity and leptin resistance. Endothelial cell leptin receptor knockout (ELKO) mice without a signaling membrane-bound leptin receptor in endothelia, however, have profound hyperleptinemia without signs of
Publikováno v:
Cellular immunology. 302
Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this stud
Publikováno v:
Brain, behavior, and immunity. 34
Leptin is commonly thought to play a detrimental role in exacerbating experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis. Paradoxically, we show here that astrocytic leptin signaling has beneficial effects in reducing disease seve
Autor:
Xiaojun Wu, Yuping Wang, Hung Hsuchou, Pramod K. Mishra, Abba J. Kastin, Suidong Ouyang, Weihong Pan
Publikováno v:
Journal of molecular neuroscience : MN. 51(2)
We have shown that mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, have upregulated leptin receptor expression in reactive astrocytes of the hippocampus, a region involved in sickness behavior. Leptin can exa
Publikováno v:
Zebrafish. 6(3)
Polyethyleneimine (PEI) has been broadly studied as a leading nonviral gene delivery carrier because of its relatively high transfection efficiency in a wide range of cell types. Here, we report gene transfer in zebrafish cells (ZF4) using PEI as a g
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69356 (2013)
PLoS ONE
PLoS ONE
Interleukin (IL)-15 is a ubiquitously expressed cytokine that in the basal state is mainly localized intracellularly, including the nucleus. Unexpectedly, tumor necrosis factor-α (TNF) time-dependently induced nuclear export of IL-15Rα and IL15. Th