Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Su, Qian"'
Publikováno v:
Digital Chinese Medicine, Vol 3, Iss 3, Pp 213-221 (2020)
Objective Pelvic inflammatory disease (PID) is one of the most common gynaecological diseases. Here, this thesis aims to investigate the therapeutic effects of Prunella vulgaris L. oil on the PID by using metabolomics based on gas chromatography- mas
Publikováno v:
European Journal of Pharmacology. 721:332-340
Hyperphosphatemia is associated with severe decline of renal function in chronic kidney disease and elevates cardiovascular mortality. Type II sodium dependent phosphate transporter 2A (Npt2A) plays a major role in renal phosphate reabsorption and co
Autor:
Alex Morrison, Bethany Rankin, Samantha Mattison, Mark A. Bryniarski, Chao Tong, Jun Wang, D. Paul Thomas, Su Qian, Ji Li
Publikováno v:
The FASEB Journal. 27:4332-4342
A “longevity ” gene, sirtuin 1 (SIRT1), can attenuate age-dependent induction of left ventricular dysfunction. This study aimed to characterize the role of SIRT1 in the tolerance of aged heart to ischemic insults. Male C57BL/6 young (4–6 mo) an
Autor:
Tung M. Fong, John R. Thompson, Wenqing Zhao, Drew T. Weingarth, Olivia Fong, Eric S. Muise, Su Qian
Publikováno v:
Molecular Pharmacology. 78:350-359
Inhibition of cannabinoid receptor 1 (CB1) has shown efficacy in reducing body weight and improving metabolic parameters, with the effects correlating with target engagement in the brain. The peripheral effects of inhibiting the CB1 receptor has been
Autor:
Margarete Mehrabian, Sana Majid, Aldons J. Lusis, Tao Xie, Pek Yee Lum, Daria Estrada-Smith, Lawrence W. Castellani, Thomas A. Drake, Robert R. Kleinhanz, Anatole Ghazalpour, Gevork Torosyan, Jun Zhu, Joshua L. Deignan, Eric E. Schadt, Su Qian, Kai Wang, Katrina M. Dipple, Jenny C Karlsson, Douglas J. MacNeil, Xia Yang, Judy Zhong, Charles R. Farber, Marc L. Reitman, Bin Zhang, Michael Coon, Chunsheng Zhang, Susanna S. Wang, John Lamb, Hongxiu Qi, Sheena Mumick, Atila van Nas, Brie Falkard
Publikováno v:
Nature genetics, vol 41, iss 4
A principal task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription
Autor:
Michael R. Tota, Su Qian, Peter Nizner, Sheena Mumick, Joseph Menetski, Marc L. Reitman, Douglas J. MacNeil
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 103:36-42
Cytosolic malic enzyme (ME-1) is a nicotinamide adenine dinucleotide phosphate (NADP)-dependent enzyme that generates NADPH. The activity of this enzyme, the reversible oxidative decarboxylation of malate to yield pyruvate, links glycolytic pathway t
Autor:
Howard Y. Chen, Marc L. Reitman, Hongyue Dai, Sheena Mumick, John S. Mudgett, Airu Chen, John Lamb, Su Qian, Drew T. Weingarth, Chunsheng Zhang, Douglas J. MacNeil
Publikováno v:
Obesity Research. 13:1311-1320
Objective: To examine the effect of a high-fat diet on gene expression in adipose tissues and to determine induction kinetics of adipose monocyte chemoattractant protein-1 and −3 (MCP-1 and MCP-3) in diet-induced obesity (DIO) and the effect of a l
Autor:
Xiao-Ming Guan, Douglas J. MacNeil, Myrna E. Trumbauer, Dawn E. Novi, Howard Y. Chen, Drew T. Weingarth, Yue Feng, Hong Yu, Airu Chen, Easter G. Frazier, Donald J. Marsh, Ramon E. Camacho, Shobhna Gopal-Truter, Lauren P. Shearman, Lex H.T. Van der Ploeg, Su Qian, Zhu Shen
Publikováno v:
Molecular and Cellular Biology. 22:5027-5035
Agouti-related protein (AgRP), a neuropeptide abundantly expressed in the arcuate nucleus of the hypothalamus, potently stimulates feeding and body weight gain in rodents. AgRP is believed to exert its effects through the blockade of signaling by alp
Autor:
Xiaojing Wang, Ying Wu, Xiangwei Wu, Hui Zheng, Xuefeng Xia, Edward H. Koo, Anthony M. Fletcher, Su Qian, Salvador Soriano
Publikováno v:
Proceedings of the National Academy of Sciences. 98:10863-10868
Presenilin 1 (PS1) is required for the proteolytic processing of Notch and the β-amyloid precursor protein (APP), molecules that play pivotal roles in cell-fate determination during development and Alzheimer's disease pathogenesis, respectively. In
Publikováno v:
Clinical and Experimental Nephrology. 4:201-206
Background. Since it has been shown that the severity of tubulointerstitial nephritis (TIN) and, in particular, the degree of monocyte infiltration, correlate both with the degree of renal impairment at biopsy and with the risk of disease progression