Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sree Deepthi Muthukrishnan"'
Autor:
Stephanie K. Seidlits, Ichiro Nakano, Harley I. Kornblum, Giovanni Coppola, Soniya Bastola, Linda M. Liau, Alireza Sohrabi, Yasmin Ghochani, Jack Mottahedeh, Steven A. Goldman, Riki Kawaguchi, Gary W. Mathern, S. Thomas Carmichael, Yue Qin, Nagesh Rao, Fuying Gao, Dan R. Laks, M. Luisa Iruela Arispe, Sree Deepthi Muthukrishnan, Michael C. Condro
SummaryGlioblastoma (GBM) is characterized by extensive microvascular hyperproliferation. In addition to supplying blood to the tumor, GBM vessels also provide trophic support to glioma cells and serve as conduits for migration into the surrounding b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20a5865842c89659e921126749fafdd7
https://doi.org/10.1101/2021.10.01.462643
https://doi.org/10.1101/2021.10.01.462643
Autor:
Harley I. Kornblum, Vivek Swarup, Aparna Bhaduri, Alvaro G. Alvarado, Kaleab Tessema, Sree Deepthi Muthukrishnan, Steven A. Goldman, Mackenzie Sober, David Nathanson, Riki Kawaguchi
Targeting glioblastoma (GBM) based on molecular subtyping have not yet translated into successful therapies. Here, we used gene set enrichment analysis (GSEA) to conduct an unsupervised clustering analysis to condense the gene expression data from bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f57926fd1b7c336c63bb677be0e5eff
https://doi.org/10.1101/2021.06.19.449118
https://doi.org/10.1101/2021.06.19.449118
Autor:
Michael C. Condro, Raymond Gau, Nathan VanderVeer-Harris, Q. Wang, Amy Pham, Yue Qin, Steven A. Goldman, Alvaro G. Alvarado, Maverick Johnson, Pooja Nair, Pedro R. Lowenstein, Rachna Prasad, Sree Deepthi Muthukrishnan, Arjun Deb, Maria G. Castro, Jason D Hinman, Daniel H. Geschwind, Riki Kawaguchi, Terry C. Burns, Frank Pajonk, Harley I. Kornblum
Treatment-refractory glioma stem and tumor cells exhibit phenotypic plasticity driving recurrence, but the underlying molecular mechanisms remain to be elucidated. Here, we employed single-cell and whole transcriptomic analyses to discover that radia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e3d98d4529be4b2c07217d687e34026
https://doi.org/10.1101/2021.06.03.447005
https://doi.org/10.1101/2021.06.03.447005
Gliomas are the most malignant and aggressive form of brain tumors, and account for the majority of brain cancer-related deaths. Malignant gliomas, including glioblastoma are treated with radiation and temozolomide, with only a minor benefit in survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d6dee60c56acfd42b0d5d3f8cfeb59
https://doi.org/10.1016/b978-0-12-821567-8.00020-8
https://doi.org/10.1016/b978-0-12-821567-8.00020-8
Autor:
Sree Deepthi Muthukrishnan, Alvaro G. Alvarado, Harley I. Kornblum, Riki Kawaguchi, Steven A. Goldman, Vivek Swarup, Kaleab Tessema
Publikováno v:
Neuro-oncology Advances
The great phenotypic heterogeneity of glioblastoma (GBM) – both inter and intratumorally – has hindered therapeutic efforts. While genome-based molecular subtyping has revealed that GBMs may be parsed into several molecularly distinct categories,
Autor:
Pooja Nair, Riki Kawaguchi, Rachna Prasad, Q. Wang, Alvaro G. Alvarado, Sree Deepthi Muthukrishnan, Michael C. Condro, Yue Qin, Harley I. Kornblum
Publikováno v:
Neuro-oncology Advances
Therapy-resistant glioma cells elicit remarkable phenotypic plasticity leading to aggressive tumor recurrence. Here, we used single-cell and whole transcriptomic sequencing to uncover that radiation treatment induces a dynamic shift in functional sta
Publikováno v:
Cell stem cell, vol 22, iss 4
Cell Stem Cell
Cell Stem Cell
Glioblastoma is the most lethal primary brain tumor, however the crosstalk between glioblastoma stem cells (GSCs) and their supportive niche is not well understood. Here, we interrogated reciprocal signaling between GSCs and their differentiated glio
Publikováno v:
Developmental Cell. 34(2):229-241
SummaryFGF, BMP, and WNT balance embryonic nephron progenitor cell (NPC) renewal and differentiation. By modulating these pathways, we have created an in vitro niche in which NPCs from embryonic kidneys or derived from human embryonic stem cells can
Publikováno v:
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
The final nephron number in an adult kidney is regulated by nephron progenitor cell availability and collecting duct branching in the fetal period. Fetal environmental perturbations that cause reductions in cell numbers in these two compartments resu
Publikováno v:
Results and Problems in Cell Differentiation ISBN: 9783319514352
New nephrons are induced by the interaction between mesenchymal progenitor cells and collecting duct tips, both of which are located at the outer edge of the kidney. This leading edge of active nephron induction is known as the nephrogenic zone. Cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbfcf1904484ccff69a108068d92c72c
https://doi.org/10.1007/978-3-319-51436-9_6
https://doi.org/10.1007/978-3-319-51436-9_6