Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Simon G. Anderson"'
With the COVID-19 pandemic leading to radical political control of social behaviour, including restricted movement outsides homes. Can more detailed analysis of the published confirmed local case data from the pandemic in England using infection rati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5f40ae5c370a22c5f275e0bddb9056
https://doi.org/10.1101/2020.04.20.20072264
https://doi.org/10.1101/2020.04.20.20072264
Autor:
Hassan S. Dashti, Daniel J. Gottlieb, Frank A.J.L. Scheer, Shaun Purcell, Max A. Little, Vincent T. van Hees, Jacqueline M. Lane, David A. Bechtold, Steven Jones, Marta Garaulet, Michael N. Weedon, Jack Bowden, Simon G. Anderson, Annemarie I. Luik, Jennifer Rhodes, Krunal Patel, Timothy M. Frayling, Jessica Tyrrell, Debbie A Lawlor, Robin N Beaumont, Andrew R. Wood, Richa Saxena, Kai Spiegelhalder, Martin K. Rutter, Andrew S. I. Loudon, Brian E. Cade, Heming Wang, Simon D. Kyle, Susan Redline, David W. Ray, Henning Tiemeier, Yanwei Song
Publikováno v:
Nature Communications, 10:1100. Nature Publishing Group
Dashti, H S, Jones, S E, Wood, A R, Lane, J M, Hees, V T V, Wang, H, Rhodes, J A, Song, Y, Patel, K, Anderson, S G, Beaumont, R N, Bechtold, D A, Bowden, J, Cade, B E, Garaulet, M, Kyle, S D, Little, M A, Loudon, A S, Luik, A I, Scheer, F A J L, Spiegelhalder, K, Tyrrell, J, Gottlieb, D J, Tiemeier, H, Ray, D W, Purcell, S M, Frayling, T M, Redline, S, Lawlor, D A, Rutter, M K, Weedon, M N & Saxena, R 2019, ' Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates ', Nat Commun, vol. 10, no. 1, 1100 . https://doi.org/10.1038/s41467-019-08917-4
Nature Communications
Dashti, H S, Jones, S E, Wood, A R, Lane, J M, van Hees, V T, Wang, H, Rhodes, J A, Song, Y, Patel, K, Anderson, S G, Beaumont, R N, Bechtold, D A, Bowden, J, Cade, B E, Garaulet, M, Kyle, S D, Little, M A, Loudon, A S, Luik, A I, Scheer, F A J L, Spiegelhalder, K, Tyrrell, J, Gottlieb, D J, Tiemeier, H, Ray, D W, Purcell, S M, Frayling, T M, Redline, S, Lawlor, D A, Rutter, M K, Weedon, M N & Saxena, R 2019, ' Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates ', Nature Communications, vol. 10, 1100 . https://doi.org/10.1038/s41467-019-08917-4
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Dashti, H S, Jones, S E, Wood, A R, Lane, J M, Hees, V T V, Wang, H, Rhodes, J A, Song, Y, Patel, K, Anderson, S G, Beaumont, R N, Bechtold, D A, Bowden, J, Cade, B E, Garaulet, M, Kyle, S D, Little, M A, Loudon, A S, Luik, A I, Scheer, F A J L, Spiegelhalder, K, Tyrrell, J, Gottlieb, D J, Tiemeier, H, Ray, D W, Purcell, S M, Frayling, T M, Redline, S, Lawlor, D A, Rutter, M K, Weedon, M N & Saxena, R 2019, ' Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates ', Nat Commun, vol. 10, no. 1, 1100 . https://doi.org/10.1038/s41467-019-08917-4
Nature Communications
Dashti, H S, Jones, S E, Wood, A R, Lane, J M, van Hees, V T, Wang, H, Rhodes, J A, Song, Y, Patel, K, Anderson, S G, Beaumont, R N, Bechtold, D A, Bowden, J, Cade, B E, Garaulet, M, Kyle, S D, Little, M A, Loudon, A S, Luik, A I, Scheer, F A J L, Spiegelhalder, K, Tyrrell, J, Gottlieb, D J, Tiemeier, H, Ray, D W, Purcell, S M, Frayling, T M, Redline, S, Lawlor, D A, Rutter, M K, Weedon, M N & Saxena, R 2019, ' Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates ', Nature Communications, vol. 10, 1100 . https://doi.org/10.1038/s41467-019-08917-4
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c4d02134916d81f9b0c481403411ba
https://publications.aston.ac.uk/id/eprint/38770/1/s41467_019_08917_4.pdf
https://publications.aston.ac.uk/id/eprint/38770/1/s41467_019_08917_4.pdf
Autor:
Rebecca C Richmond, Heming Wang, David W. Ray, Jacqueline M. Lane, Annemarie I. Luik, David A. Bechtold, Max A. Little, Yanwei Song, Simon D. Kyle, Michael N. Weedon, Mary E. Haas, Krishna G. Aragam, Debbie A Lawlor, Martin K. Rutter, Cristen J. Willer, Jessica Tyrrell, Susan Redline, Samuel E. Jones, Vincent T. van Hees, John-Anker Zwart, Kai Spiegelhalder, Barbara Schormair, Krunal Patel, Timothy M. Frayling, Andrew S. I. Loudon, Brian E. Cade, Robin N Beaumont, Bendik S. Winsvold, Sekar Kathiresan, Andrew R. Wood, Juliane Winkelmann, Richa Saxena, Ben Michael Brumpton, Hunt All In Sleep, Linn B Strand, Kristian Hveem, John W. Winkelman, Shaun Purcell, Frank A.J.L. Scheer, Jonas B. Nielsen, Hassan S. Dashti, Chen Zhao, Simon G. Anderson, Jack Bowden
Publikováno v:
Nature genetics
Nature Genetics, 51(3), 387-+. Nature Publishing Group
Nat. Genet. 51, 387-393 (2019)
HUNT All In Sleep, Anderson, S & Rutter, M 2019, ' Biological and clinical insights from genetics of insomnia symptoms ', Nature Genetics, vol. 51, pp. 387-393 . https://doi.org/10.1038/s41588-019-0361-7
Nature Genetics
Lane, J M, Jones, S E, Dashti, H S, Bowden, J, Lawlor, D A, Rutter, M K, Weedon, M N & Saxena, R 2019, ' Biological and clinical insights from genetics of insomnia symptoms ', Nature Genetics, vol. 51, no. 3, pp. 387–393 . https://doi.org/10.1038/s41588-019-0361-7
Nature Genetics, 51(3), 387-+. Nature Publishing Group
Nat. Genet. 51, 387-393 (2019)
HUNT All In Sleep, Anderson, S & Rutter, M 2019, ' Biological and clinical insights from genetics of insomnia symptoms ', Nature Genetics, vol. 51, pp. 387-393 . https://doi.org/10.1038/s41588-019-0361-7
Nature Genetics
Lane, J M, Jones, S E, Dashti, H S, Bowden, J, Lawlor, D A, Rutter, M K, Weedon, M N & Saxena, R 2019, ' Biological and clinical insights from genetics of insomnia symptoms ', Nature Genetics, vol. 51, no. 3, pp. 387–393 . https://doi.org/10.1038/s41588-019-0361-7
Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identify 57 loci for self-repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5a5daacc25a1f0d67968922d68f0a1
https://ora.ox.ac.uk/objects/uuid:f54a5dbd-5aea-4f4f-94aa-97543cd3774b
https://ora.ox.ac.uk/objects/uuid:f54a5dbd-5aea-4f4f-94aa-97543cd3774b
Autor:
Max A. Little, Michael N. Weedon, Jack Bowden, Rebecca C Richmond, Shaun Purcell, Hanna Ollila, Frank A.J.L. Scheer, Jacqueline M. Lane, Kristian Hveem, Sonja Sulkava, Cristen J. Willer, Samuel E. Jones, Kai Spiegelhalder, Heming Wang, Linn B Strand, Andrew R. Wood, Krunal Patel, Timothy M. Frayling, Andrew S. I. Loudon, Richa Saxena, Debbie A Lawlor, Martin K. Rutter, Jessica Tyrrell, Ben Michael Brumpton, David A. Bechtold, John-Anker Zwart, Jonas B. Nielsen, Katri Kantojärvi, Hassan S. Dashti, Vincent T. van Hees, Brian E. Cade, Tamar Sofer, Richard Emsley, Simon G. Anderson, Yanwei Song, Simon D. Kyle, Kati Kristiansson, Xiaofeng Zhu, Susan Redline, Tiina Paunio, Bendik S. Winsvold, David W. Ray
Excessive daytime sleepiness (EDS) affects 10-20% of the population and is associated with substantial functional deficits. We identified 42 loci for self-reported EDS in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30373454a8ccaee76bbebd2de4975c91
https://doi.org/10.1101/454561
https://doi.org/10.1101/454561
Autor:
Max A. Little, Richa Saxena, Simon G. Anderson, Andrew S. I. Loudon, Shubhroz Gill, Debbie A Lawlor, Richard Emsley, Martin K. Rutter, Irma Vlasac, David A. Bechtold, Jacqueline M. Lane, David W. Ray, Simon D. Kyle, Susan Redline, Frank A.J.L. Scheer, Annemarie I. Luik, William G Dixon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Lane, J M, Vlasac, I, Anderson, S G, Kyle, S D, Dixon, W G, Bechtold, D A, Gill, S, Little, M A, Luik, A, Loudon, A, Emsley, R, Scheer, F A J L, Lawlor, D A, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2016, ' Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank ', Nature Communications, vol. 7, 10889 . https://doi.org/10.1038/ncomms10889
Nature Communications
Lane, J M, Vlasac, I, Anderson, S G, Kyle, S D, Dixon, W G, Bechtold, D A, Gill, S, Little, M A, Luik, A, Loudon, A, Emsley, R, Scheer, F A J L, Lawlor, D A, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2016, ' Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank ', Nature Communications, vol. 7, 10889 . https://doi.org/10.1038/ncomms10889
Nature Communications
Our sleep timing preference, or chronotype, is a manifestation of our internal biological clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and chronic disease. Here we perform a genome-wide associ
Autor:
Michael N. Weedon, Jack Bowden, Jennifer Rhodes, Annemarie I. Luik, Vincent T. van Hees, Jacqueline M. Lane, Max A. Little, Andrew R. Wood, Debbie A Lawlor, Richa Saxena, Martin K. Rutter, Kai Spiegelhalder, Marta Garaulet, Heming Wang, Shaun Purcell, Brian E. Cade, Hassan S. Dashti, Krunal Patel, Timothy M. Frayling, David A. Bechtold, Daniel J. Gottlieb, Yanwei Song, Robin N Beaumont, Jessica Tyrrell, Scheer Fajl., David W. Ray, Henning Tiemeier, Simon D. Kyle, Steven Jones, Simon G. Anderson, Susan Redline, Andrew S. I. Loudon
Sleep is an essential homeostatically-regulated state of decreased activity and alertness conserved across animal species, and both short and long sleep duration associate with chronic disease and all-cause mortality1,2. Defining genetic contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c584e8669b54ef36a5007708377ef84
Autor:
Xiaofeng Zhu, Shubhroz Gill, Jack Bowden, Frank A.J.L. Scheer, Annemarie I. Luik, Richard Emsley, David A. Bechtold, Jacqueline M. Lane, Shaun Purcell, Irma Vlasac, Martin K. Rutter, Andrew S. I. Loudon, Richa Saxena, Simon G. Anderson, Jingjing Liang, Max A. Little, Debbie A Lawlor, Simon D. Kyle, Susan Redline, David W. Ray
Publikováno v:
Lane, J M, Liang, J, Vlasac, I, Anderson, S, Bechtold, D, Bowden, J, Emsley, R, Gill, S, Little, M A, Luik, A, Loudon, A, Scheer, F A J L, Purcell, S, Kyle, S D, Lawlor, D A, Zhu, X, Redline, S, Ray, D, Rutter, M & Saxena, R 2016, ' Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits ', Nature Genetics, vol. 49, pp. 274-281 . https://doi.org/10.1038/ng.3749
Lane, J M, Liang, J, Vlasac, I, Anderson, S G, Bechtold, D A, Bowden, J, Emsley, R, Gill, S, Little, M A, Luik, A I, Loudon, A, Scheer, F A J L, Purcell, S M, Kyle, S D, Lawlor, D A, Zhu, X, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2017, ' Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits ', Nature Genetics, vol. 49, no. 2, pp. 274-281 . https://doi.org/10.1038/ng.3749
Lane, J, Liang, J, Vlasac, I, Anderson, S G, Bechtold, D A, Bowden, J, Emsley, R, Gill, S, A Little, M, Luik, A I, Loudon, A, Scheer, F A J L, Purcell, S M, Kyle, S D, Lawlor, D, Zhu, X, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2017, ' Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits ', Nature Genetics, vol. 49, no. 2, pp. 274–281 . https://doi.org/10.1038/ng.3749
Lane, J M, Liang, J, Vlasac, I, Anderson, S G, Bechtold, D A, Bowden, J, Emsley, R, Gill, S, Little, M A, Luik, A I, Loudon, A, Scheer, F A J L, Purcell, S M, Kyle, S D, Lawlor, D A, Zhu, X, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2017, ' Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits ', Nature Genetics, vol. 49, no. 2, pp. 274-281 . https://doi.org/10.1038/ng.3749
Lane, J, Liang, J, Vlasac, I, Anderson, S G, Bechtold, D A, Bowden, J, Emsley, R, Gill, S, A Little, M, Luik, A I, Loudon, A, Scheer, F A J L, Purcell, S M, Kyle, S D, Lawlor, D, Zhu, X, Redline, S, Ray, D W, Rutter, M K & Saxena, R 2017, ' Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits ', Nature Genetics, vol. 49, no. 2, pp. 274–281 . https://doi.org/10.1038/ng.3749
Chronic sleep disturbances, associated with cardio-metabolic diseases, psychiatric disorders and all-cause mortality1,2, affect 25–30% of adults worldwide3. While environmental factors contribute importantly to self-reported habitual sleep duration
Autor:
J. M. Gibson, A. Vyas, Simon G. Anderson, Deepak Bhatnagar, Elizabeth A. Hughes, Dorairaj Prabhakaran, A. P. Yates, Kirk Siddals, John Kennedy Cruickshank, Paul N. Durrington, J Patel, Adrian H. Heald, A. Rudenski
Publikováno v:
Diabetologia. 48:1756-1765
We previously reported independent links between the IGF system and the development of impaired glucose tolerance and cardiovascular risk. This study tests the hypothesis that the lifestyle change which accompanies population migration, with attendan
Autor:
Kirk Siddals, Reena Sharma, Sara F. L. Kirk, Adrian H. Heald, Janet E Cade, Cheryl Golding, Clare L. Lawton, J. Martin Gibson, Simon G. Anderson
Publikováno v:
British Journal of Nutrition. 92:809-818
There are two key methods in which fat intake may be manipulated; the ‘substitution model’ and the ‘reduction model’. However insufficient information is known about the mechanisms of dietary fat reduction in individuals who have successfully
Autor:
Yanming Jiang, Simon G. Anderson, Donghui Kan, Martin Farrall, Adebowale Adeyemo, Xiaofeng Zhu, Terrence Forrester, Colin A. McKenzie, Ryk Ward, Nourdine Bouzekri, Amy Luke, Richard S. Cooper
Publikováno v:
European Journal of Human Genetics. 12:460-468
The genes in the renin-angiotensin system are important physiologic candidates in studies of the genetic susceptibility to hypertension. Limited information has been available in most studies on the extent of variation in the candidate loci or the mo