Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Shyam S. Chauhan"'
Publikováno v:
Annals of the National Academy of Medical Sciences (India), Vol 57, Iss 02, Pp 108-116 (2021)
Cysteine cathepsins are lysosomal proteases that require Cys-His ion pair in their catalytic site for enzymatic activity. While their aberrant expression and oncogenic functions have been widely reported in solid tumors, recent findings suggest that
Publikováno v:
Cancer Immunology, Immunotherapy. 70:349-363
Thymocyte selection-associated high mobility group box protein (TOX) is a transcription factor implicated in the regulation of T cell exhaustion during chronic infection and cancer. While TOX is being targeted for cancer immunotherapy, limited inform
Autor:
Lokesh K Kadian, Rajni Yadav, Jay Singh, Sarita Kumari, Mohit Arora, Shyam S. Chauhan, Anita Chopra
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, Vol 8 (2021)
Hepatocellular carcinoma (HCC) is an aggressive gastrointestinal malignancy with a high rate of mortality. Multiple studies have individually recognized members of RAP gene family as critical regulators of tumor progression in several cancers, includ
Autor:
Ashok Sharma, Ritu Gupta, Neerja Bhatla, Sunesh Kumar, Lalit Kumar, Minakshi Mann, Sachin Kumar, Sameer Bakhshi, Shyam S. Chauhan
Publikováno v:
Oncotarget
Cisplatin is a keystone for treatment of both recurring and locally advanced cervical cancer. However toxic side effects and acquired resistance limits its efficacy. Enhanced DNA repair is one of the mechanisms through which cancer cells acquire cisp
Publikováno v:
3 Biotech
L-selectin is a cell adhesion molecule that plays an important role in modulating immune cell trafficking. The expression of L-selectin has been found to be upregulated in several human cancers. However, the association of L-selectin expression with
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences, Vol 7 (2020)
Classical Non-homologous End Joining (NHEJ) pathway is the mainstay of cellular response to DNA double strand breaks. While aberrant expression of genes involved in this pathway has been linked with genomic instability and drug resistance in several
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
The human implantation failure during first trimester leads to spontaneous abortions. Spontaneous abortions are consecutive and occur twice or thrice (with or without prior live births) due to factors which are either maternal or fetal. However, it a
Autor:
Rajni Yadav, Shyam S. Chauhan, Peush Sahni, Rajesh Panwar, Ratnakar Singh, Siddharth Mehra, Nihar Ranjan Dash, Bhaskar Thakur, Manish Kumar
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology, Vol 9 (2019)
Background: Gallbladder carcinoma (GBC) exhibits poor prognosis due to its detection at an advanced stage. Upregulation of lysosomal cysteine proteases cathepsin L (CTSL) and cathepsin B (CTSB) has been implicated in several tumorigenic processes. Ho
Autor:
Neelam Pushker, Radhika Tandon, Murugesan Vanathi, Shyam S. Chauhan, Anjana Sharma, Seema Kashyap, Sheetal Chauhan, Seema Sen
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 26:e70-e76
Conjunctival squamous cell carcinoma (SCC) is the most common tumor of conjunctival epithelium. It is associated with risk of permanent visual impairment and has the capability to recur, metastasize, and cause death. Deregulation of cell cycle contro
Publikováno v:
Leukemia & Lymphoma. 59:2175-2187
Overexpression of cathepsin L (CTSL), an endolysosomal cysteine protease, is associated with inferior survival of patients with various human malignancies. We evaluated the expression/activity of CTSL in peripheral blood mononuclear cells (PBMCs) and