Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Samuel K. Handelman"'
Autor:
Brian D. Halligan, Annapurna Kuppa, Vincent L. Chen, Elizabeth K. Speliotes, Lawrence F. Bielak, Yanhua Chen, Xiaomeng Du, Samuel K. Handelman, Patricia A. Peyser, Rishel B. Vohnoutka, Nicholette D. Palmer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Hepatology
Nature Communications
Hepatology
Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We ident
Autor:
Allison L. Kuipers, Michele K. Evans, Liubov Arbeeva, Ching-Ti Liu, Tamara B. Harris, Michelle S. Yau, Aude Nicolas, Salman M. Tajuddin, Joanne M. Jordan, Struan F.A. Grant, Ryan Price, Rebecca D. Jackson, Douglas P. Kiel, Babette S. Zemel, Samuel K. Handelman, Yi-Hsiang Hsu, David Karasik, Joseph M. Zmuda, Alessandra Chesi
Publikováno v:
J Bone Miner Res
Genetic studies of bone mineral density (BMD) largely have been conducted in European populations. We therefore conducted a meta-analysis of six independent African ancestry cohorts to determine whether previously reported BMD loci identified in Euro
Autor:
Agnieszka H. Ludwig-Slomczynska, Ewa Wender-Ozegowska, Łucja Dobrucka, Paweł Gutaj, Ewelina Pitera, Katarzyna Cyganek, Urszula Mantaj, Przemysław Kapusta, Paweł Wołkow, Samuel K. Handelman, Maciej T. Malecki, Michał T. Seweryn
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-11 (2020)
BMC Medical Genomics
BMC Medical Genomics
Background BMI is a strong indicator of complications from type I diabetes, especially under intensive treatment. Methods We have genotyped 435 type 1 diabetics using Illumina Infinium Omni Express Exome-8 v1.4 arrays and performed mitoGWAS on BMI. W
Autor:
Eun-Young Choi, Yanhua Chen, Asmita Pant, Annapurna Kuppa, Jonathan Z. Sexton, Lillias H. Maguire, Thomas L. Saunders, Samuel K. Handelman, Devika P. Bagchi, Elizabeth K. Speliotes, Lawrence F. Bielak, Yue Chen, Sean M McCarty, Rishel B. Vohnoutka, Xiaomeng Du, Brian D. Halligan, Vincent L. Chen, Yash Hegde
Human genome-wide association studies found SNPs near LYPLAL1 that have sex-specific effects on fat distribution and metabolic traits. To determine whether altering LYPLAL1 affects obesity and metabolic disease we created and characterized a mouse kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6221f8d37a11b2b18d58c7dd95f3c84
https://doi.org/10.1101/2021.08.05.455257
https://doi.org/10.1101/2021.08.05.455257
Autor:
Rishel Vohnoutka, Jonathan Z. Sexton, Christopher E. Turner, Kyle M. Alpha, Gregory J. Goreczny, Samuel K. Handelman, Anushree C. Gulvady
Publikováno v:
Molecular Biology of the Cell
Focal adhesion (FA)-stimulated reorganization of the F-actin cytoskeleton regulates cellular size, shape, and mechanical properties. However, FA cross-talk with the intermediate filament cytoskeleton is poorly understood. Genetic ablation of the FA-a
Publikováno v:
J Nutr
BACKGROUND: High macular pigment optical density (MPOD) has been associated with improved eye health and better cognitive functions. Genetic variations have been associated with MPOD in adults. However, these associations between genetic variations a
Autor:
Lillias H. Maguire, Yanhua Chen, Tune H. Pers, Elizabeth K. Speliotes, Samuel K. Handelman, Xiaomeng Du
Publikováno v:
Nature genetics
Diverticular disease is common and has a high morbidity. Treatments are limited owing to the poor understanding of its pathophysiology. Here, to elucidate its etiology, we performed a genome-wide association study of diverticular disease (27,444 case
Autor:
Sanjay Lakhotia, Daniel E. Spratt, Anbarasu Kumaraswamy, Eric J. Small, Joel A. Yates, Colm Morrissey, Dae Hwan Kim, Felix Y. Feng, Xiangnan Guan, Eric Campeau, Eva S. Rodansky, Himisha Beltran, Jonathan Z. Sexton, Sarah Attwell, Jared M. Lucas, Joshua Urrutia, Wassim Abida, Eva Corey, Katherine Welker Leng, Emily M. Gesner, Chelsea Jenkins, David A. Sampson, Chao Zhang, Samuel K. Handelman, Rahul Aggarwal, Peter S. Nelson, Joshi J. Alumkal, William K. Storck, Jacob Schwartzman, Zheng Xia, Mark P. Labrecque, Daniel J. Coleman, Duanchen Sun, Armand Bankhead, Ilsa Coleman, Arvind Rao
Publikováno v:
Clin Cancer Res
Purpose: Lineage plasticity in prostate cancer—most commonly exemplified by loss of androgen receptor (AR) signaling and a switch from a luminal to alternate differentiation program—is now recognized as a treatment resistance mechanism. Lineage p
Autor:
Michele K. Evans, Joseph M. Zmuda, Aude Nicolas, Rebecca D. Jackson, Michelle S. Yau, Tamara B. Harris, Alessandra Chesi, Yi-Hsiang Hsu, Salman M. Tajuddin, Struan F.A. Grant, Joanne Marie Jordan, Liubov Arbeeva, Ryan Price, Samuel K. Handelman, Douglas P. Kiel, Babette S. Zemel, Ching-Ti Liu, David Karasik, Allison L. Kuipers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02f9496c0b5f135d853eeac97b12e56d
https://doi.org/10.1002/jbmr.4220/v3/response1
https://doi.org/10.1002/jbmr.4220/v3/response1
Publikováno v:
Liver Int
BACKGROUND AND AIMS: Cirrhosis is characterized by extensive fibrosis of the liver and is a major cause of liver-related mortality. Cirrhosis is partially heritable but genetic contributions to cirrhosis have not been systemically explored. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cffb004c6602c9357b99be3b900846
https://europepmc.org/articles/PMC7395656/
https://europepmc.org/articles/PMC7395656/