Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Philippe Bois"'
Publikováno v:
Mammalian Genome. 12:104-111
Mouse expanded simple tandem repeats (ESTRs) provide highly informative loci for analyzing spontaneous and induced germline mutation. We have conducted an extensive sequence database search and identified 17 new members of the highly unstable rodent-
Autor:
Yuri E. Dubrova, Alistair Ritchie, Celia A. May, Alec J. Jeffreys, John D.H. Stead, Angela C. Shone, Keiji Tamaki, Ruth C. Barber, Esther Signer, Caroline R. H. Hollies, Rita Neumann, Gemma R. Grant, Maria Panayi, Philippe Bois, Jérôme Buard
Publikováno v:
Electrophoresis. 20:1665-1675
Minisatellites include some of the most variable loci in the human genome and are superb for dissecting processes of tandem repeat DNA instability. Single DNA molecule analysis has revealed different mutation processes operating in the soma and germl
Publikováno v:
Genetical Research. 72:59-72
Autor:
Sharmila Bakshi, Alec J. Jeffreys, Philippe Bois, Behzad Moghadaszadeh, John D.H. Stead, Rita Neumann, Jill Williamson
Publikováno v:
Genomics. 50:317-330
Minisatellites provide the most informative system for analyzing processes of tandem repeat turnover in humans. However, little is known about minisatellites and the mechanisms by which they mutate in other species. To this end, we have isolated and
Publikováno v:
Human Molecular Genetics. 6:1565-1571
Human minisatellite MS32 (D1S8) shows instability both in the germline and, at much lower levels, in somatic DNA. To investigate factors that influence somatic and germline mutation, large cosmid-based constructs containing MS32 were introduced into
Autor:
Andrew Collick, Wolf Reik, J. Drew, Alec J. Jeffreys, Philippe Bois, J. Penberth, Jeni Luckett, F. Scaerou
Publikováno v:
Scopus-Elsevier
Various sequences in the mammalian genomes are unstable. One class of sequence arrangement is long inverted repeats, which are known to be unstable in bacteria and yeast. While in mammals some evidence suggests that short inverted repeats (
Publikováno v:
Genomics. 80(1)
Minisatellites provide very informative systems for analyzing processes of tandem repeat DNA turnover in humans. The mouse genome also contains authentic minisatellites, but none has yet been found to show high levels of instability. Indirect evidenc
Autor:
Alec J. Jeffreys, Philippe Bois
Publikováno v:
Cellular and molecular life sciences : CMLS. 55(12)
Tandem-repeat DNA actively turns over in the genome by a variety of poorly understood dynamic mechanisms. Minisatellites, a class of tandem repeats, have been shown to cause disease by influencing gene expression, modifying coding sequences within ge
Autor:
Jane Brown, Mark Plumb, V. A. Ostapenko, V.N. Nesterov, Alec J. Jeffreys, N. G. Krouchinsky, Yuri E. Dubrova, Philippe Bois
Publikováno v:
Fundamentals for the Assessment of Risks from Environmental Radiation ISBN: 9780792356684
Germline mutation at human minisatellite loci has been studied among children born in areas of the Mogilev district of Belarus heavily polluted after the Chernobyl accident. The overall mutation rate was twice as high in the exposed group as in contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1af72a0750b0d753254c53f4461aed0
https://doi.org/10.1007/978-94-011-4585-5_33
https://doi.org/10.1007/978-94-011-4585-5_33
Autor:
Philippe Bois, Alec J. Jeffreys, Jan Fennelly, Mark Plumb, Dudley T. Goodhead, Yuri E. Dubrova, Julia Brown
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 95(11)
Germ-line mutation induction at mouse minisatellite loci by acute irradiation with x-rays was studied at premeiotic and postmeiotic stages of spermatogenesis. An elevated paternal mutation rate was found after irradiation of premeiotic spermatogonia