Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Paul McNally"'
Autor:
Sarath Ranganathan, Barry Linnane, André Schultz, Graham L. Hall, Paul McNally, Yuliya V. Karpievitch, S. Stick, Daryl Butler
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 204:605-608
Autor:
Catherine M. Greene, Paul McNally
Publikováno v:
Expert Review of Precision Medicine and Drug Development. 3:107-117
Introduction: Cystic Fibrosis is a recessive monogenetic disease caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), a chloride ion channel expressed by epithelial cells throughout the body. Althou
Autor:
Gerard Higgins, Valerie Urbach, Coral Fustero Torre, Jean Tyrrell, Paul McNally, Brian J. Harvey
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2016, 310 (11), pp.L1053-L1061. ⟨10.1152/ajplung.00368.2015⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2016, 310 (11), pp.L1053-L1061. ⟨10.1152/ajplung.00368.2015⟩
The specialized proresolution lipid mediator lipoxin A4(LXA4) is abnormally produced in cystic fibrosis (CF) airways. LXA4increases the CF airway surface liquid height and stimulates airway epithelial repair and tight junction formation. We report he
Autor:
Donna M. Small, Rebecca J. Ingram, Nicolas Camper, Joseph Elborn, Arlene Glasgow, Fionnuala Lundy, Derek J. Quinn, D. McLean, Megan Osbourn, Clifford C. Taggart, Sinéad Weldon, Paul McNally
Publikováno v:
Camper, N, Glasgow, A M A, Osbourn, M, Quinn, D J, Small, D M, McLean, D T, Lundy, F T, Elborn, J S, McNally, P, Ingram, R J, Weldon, S & Taggart, C C 2016, ' A Secretory Leukocyte Protease Inhibitor Variant with Improved Activity against Lung Infection ', Mucosal immunology, vol. 9, no. 3, pp. 669-676 . https://doi.org/10.1038/mi.2015.90
Secretory leukocyte protease inhibitor (SLPI) is an important respiratory tract host defense protein, which is proteolytically inactivated by excessive neutrophil elastase (NE) during chronic Pseudomonas infection in the cystic fibrosis (CF) lung. We
Autor:
Noel G. McElvaney, Catherine M. Greene, Kevin Gaughan, Gerard Higgins, Paul McNally, Kevin Molloy, Marcus A. Mall, Sebastian Vencken, Irene Oglesby, Raman Agrawal
Publikováno v:
European Respiratory Journal. 46:1350-1360
Interleukin (IL)-8 levels are higher than normal in cystic fibrosis (CF) airways, causing neutrophil infiltration and non-resolving inflammation. Overexpression of microRNAs that target IL-8 expression in airway epithelial cells may represent a thera
Autor:
Paul McNally, Cecilia O'Kane, Sinéad Weldon, Daniel F. McAuley, D. McLean, Nicolas Camper, J. Stuart Elborn, Donna M. Small, Fionnuala Lundy, Shauna Hegarty, Aaron Scott, Arlene Glasgow, Dhruv Parekh, Clifford C. Taggart, Umar Hamid
Publikováno v:
Glasgow, A M A, Small, D M, Scott, A, McLean, D T, Camper, N, Hamid, U, Hegarty, S, Parekh, D, O'Kane, C, Lundy, F T, McNally, P, Elborn, J S, McAuley, D F, Weldon, S & Taggart, C C 2015, ' A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung ', Thorax, vol. 70, no. 5, pp. 426-32 . https://doi.org/10.1136/thoraxjnl-2014-206488
Introduction: Secretory leucocyte protease inhibitor and elafin are members of the whey acidic protein (WAP), or WAP four disulfide-core (WFDC), family of proteins and have multiple contributions to innate defence including inhibition of neutrophil s
Autor:
Clifford C. Taggart, Sinéad Weldon, Thierry Moreau, Arlene Glasgow, Cecilia O'Kane, Derek J. Quinn, Paul McNally, Daniel F. McAuley, Sandrine Dallet-Choisy, Donna M. Small, Marie Louise Zani
Publikováno v:
Small, D M, Zani, M L, Quinn, D J, Dallet-Choisy, S, Glasgow, A MA, O'Kane, C, Mcauley, D F, Mcnally, P, Weldon, S, Moreau, T & Taggart, C C 2015, ' A Functional Variant of Elafin With Improved Anti-inflammatory Activity for Pulmonary Inflammation ', Molecular therapy : the journal of the American Society of Gene Therapy, vol. 23, no. 1, pp. 24-31 . https://doi.org/10.1038/mt.2014.162
Elafin is a serine protease inhibitor produced by epithelial and immune cells with anti-inflammatory properties. Research has shown that dysregulated protease activity may elicit proteolytic cleavage of elafin, thereby impairing the innate immune fun
Autor:
Clifford C. Taggart, Christopher J. Scott, Paul B. McCray, Sinéad Weldon, Paul McNally, Catherine M. Greene, Irene Oglesby, Noel G. McElvaney, Jennifer A. Bartlett, Daniel F. McAuley, Christine L. Wohlford-Lenane
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 190:165-174
Rationale: Cathepsin S (CTSS) activity is increased in bronchoalveolar lavage (BAL) fluid from patients with cystic fibrosis (CF). This activity contributes to lung inflammation via degradation of antimicrobial proteins, such as lactoferrin and membe
Autor:
F. Healy, Marianne S. Muhlebach, Michelle A. Murray, Michael M. Tunney, Kevin Molloy, Matthew C. Wolfgang, Catherine M. Greene, Noel G. McElvaney, Gillian M. Lavelle, Cedric Gunaratnam, Joe Hatch, Paul McNally, Ahmed Abdul Azim, Dubhfeasa Slattery, Bojana Mirković, Rosaleen Devery
Anaerobic bacteria are present in large numbers in the airways of people with cystic fibrosis (PWCF). In the gut, anaerobes produce short-chain fatty acids (SCFAs) that modulate immune and inflammatory processes.To investigate the capacity of anaerob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42348b8050679e5e375f9889a6194856
https://europepmc.org/articles/PMC4731701/
https://europepmc.org/articles/PMC4731701/
Autor:
Stef J. McGrath, J. Stuart Elborn, Michelle A. Murray, Richard C. Boucher, Bojana Mirković, Sonia Davis Thomas, Matthew C. Wolfgang, Gillian M. Lavelle, Paul McNally, Joseph Hatch, Nathan Gotman, Peter H. Gilligan, Michael M. Tunney, Noel G. McElvaney, Deirdre F Gilipin, Gisli G. Einarsson, Marianne S. Muhlebach
Publikováno v:
European Respiratory Journal. 52:1800242
Anaerobic and aerobic bacteria were quantitated in respiratory samples across three cystic fibrosis (CF) centres using extended culture methods. Subjects aged 1–69 years who were clinically stable provided sputum (n=200) or bronchoalveolar lavage (