Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Patrycja Gazinska"'
Autor:
Ioannis Roxanis, Laura Ramos Garcia, James M. Murphy, Sidonie Wicky John, Isabelle S Lucet, Andrew J. Kueh, Allison M. Beal, K. Aurelia Ball, Jyoti S. Choudhary, Cheree Fitzgibbon, Richard Newman, Jason W. Upton, Martin Sims, Lu Yu, George Ward, Gianmaria Liccardi, Winnie Fernando, Patrycja Gazinska, Naomi Guppy, Brad J. Geddes, Hyojin Kim, Samuel N. Young, Rachel O. Haich, Pascal Meier, Lung-Yu Liang, Mercedes Pardo, Tomoko Smyth, John Bertin, Tencho Tenev, Alessandro Annibaldi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which is thought to initiate MLKL o
Autor:
Julie Owen, Cristina Naceur-Lombardelli, Fernanda Kyle-Cezar, Adrian Hayday, Anita Grigoriadis, Pierre Vantourout, Andrew Tutt, Dhruva Biswas, Patrycja Gazinska, Yin Wu, R T Woolf, Anna Lorenc
Publikováno v:
Science Translational Medicine. 11
Innate-like tissue-resident γδ T cell compartments capable of protecting against carcinogenesis are well established in mice. Conversely, the degree to which they exist in humans, their potential properties, and their contributions to host benefit
Autor:
Patrycja Gazinska, Julie Foster, Roxana Kashani, John Maher, Sophie Papa, Jane K. Sosabowski, Nia Emami-Shahri, Celia Cook
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Emami-Shahri, N, Foster, J, Kashani, R, Gazinska, P, Cook, C, Maher, J, Sosabowski, J & Papa, S 2018, ' Clinically Compliant Spatial and Temporal Imaging of Chimeric Antigen Receptor T-cells ', Nature Communications, vol. 9, no. 1, 1081 . https://doi.org/10.1038/s41467-018-03524-1
Nature Communications
Emami-Shahri, N, Foster, J, Kashani, R, Gazinska, P, Cook, C, Maher, J, Sosabowski, J & Papa, S 2018, ' Clinically Compliant Spatial and Temporal Imaging of Chimeric Antigen Receptor T-cells ', Nature Communications, vol. 9, no. 1, 1081 . https://doi.org/10.1038/s41467-018-03524-1
The unprecedented efficacy of chimeric antigen receptor (CAR) T-cell immunotherapy of CD19+ B-cell malignancy has established a new therapeutic pillar of hematology–oncology. Nonetheless, formidable challenges remain for the attainment of comparabl
Autor:
Anthony Cheung, Diana Dominguez Rodriguez, Mariangela Figini, James Spicer, Anita Grigoriadis, Cheryl Gillett, Nirmesh Patel, James W. Opzoomer, Angela Clifford, Matthew Fittall, Giulia Pellizzari, Patrycja Gazinska, Hasan Mirza, Luned M. Badder, Andrew Tutt, Frank O. Nestle, Daniel Larcombe-Young, Silvia Mele, Debra H. Josephs, Rebecca Marlow, Sophia N. Karagiannis, Silvia Crescioli, Sarah E Pinder, Heather J. Bax, Gyula M. Petranyi, Erika Francesch-Domenech, Silvana Canevari, Ricarda M. Hoffmann, Kristina M. Ilieva
Publikováno v:
Cheung, A, Opzoomer, J W, Ilieva, K M, Gazinska, P, Hoffmann, R M, Mirza, H, Marlow, R, Francesch-Domenech, E, Fittall, M W, Dominguez Rodriguez, D, Clifford, A, Badder, L, Patel, N, Mele, S, Pellizzari, G, Bax, H J, Crescioli, S, Petranyi, G, Larcombe-Young, D, Josephs, D H, Canevari, S, Figini, M, Pinder, S E, Nestle, F O, Gillett, C, Spicer, J, Grigoriadis, A, Tutt, A & Karagiannis, S N 2018, ' Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer ', Clinical Cancer Research, vol. 24, no. 20, pp. 5098-5111 . https://doi.org/10.1158/1078-0432.CCR-18-0652
Purpose: Highly aggressive triple-negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3bf16519826e1575a3ac479dab144a
https://kclpure.kcl.ac.uk/en/publications/8d47713f-0302-4f11-8ad1-211948bd6f02
https://kclpure.kcl.ac.uk/en/publications/8d47713f-0302-4f11-8ad1-211948bd6f02
Autor:
Cheryl Gillett, Hasan Mirza, Markus Mayrhofer, Maggie C.U. Cheang, Vandna Shah, Johnathan Watkins, Shalaka Joshi, Maria Jasin, Alan Ashworth, Fabio Vanoli, Andrew Tutt, Bhavna Sidhu, Anders Isaksson, Anita Grigoriadis, Shaveta Vinayak, Melinda L. Telli, Patrycja Gazinska, Sarah E Pinder, Jessica Frankum, Christopher J. Lord, Daniel Weekes, James M. Ford
Publikováno v:
Cancer discovery, vol 5, iss 5
Triple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some of which might be caused by defects in DNA repair processes such as homologous recombination (HR). Despite this understanding, associating particu
Autor:
Fiona M. Blows, Sarah-Jane Dawson, Jelle Wesseling, Ian W. Brock, William J. Howat, Wilma E. Mesker, Veli-Matti Kosma, Penny Coulson, Leigh-Anne McDuffus, Rainer Fagerholm, Sarah E Pinder, Carolien H.M. van Deurzen, Angela Cox, Lorna Morris, Malcolm W.R. Reed, Arto Mannermaa, Louise Jones, Carl Blomqvist, Reijo Sironen, Daniel W. Visscher, Vesa Kataja, Annegien Broeks, Janet E. Olson, Simon S. Cross, Patrycja Gazinska, Mark E. Sherman, Marjanka K. Schmidt, Joyce Sanders, Manjeet K. Bolla, Jonine D. Figueroa, Caroline M. Seyaneve, Paul D.P. Pharoah, Elena Provenzano, Douglas F. Easton, Päivi Heikkilä, Mark N. Brook, Elinor J. Sawyer, Jose Ignacio Arias Perez, Javier Benítez, Heli Nevanlinna, Montserrat Garcia-Closas, Peter Devillee, Jolanta Lissowska, Primitiva Menéndez, Carlos Caldas, Louise A. Brinton, Nicola Johnson, Jodi Miller, Frances Daley, Fergus J. Couch, H. Raza Ali, Antoinette Hollestelle
Publikováno v:
The Journal of Pathology: Clinical Research. 1:18-32
Breast cancer risk factors and clinical outcomes vary by tumour marker expression. However, individual studies often lack the power required to assess these relationships, and large-scale analyses are limited by the need for high throughput, standard
Autor:
Emanuele de Rinaldis, Brian Burford, Cheryl Gillett, Pierfrancesco Marra, Anca Mera, Aisyah Mohd Noor, Filipe Gracio, Patrycja Gazinska, Sarah E Pinder, Andrew Tutt, Anita Grigoriadis
Publikováno v:
Gracio, F, Burford, B, Gazinska, P, Mera, A, Mohd Noor, A, Marra, P, Gillett, C, Grigoriadis, A, Pinder, S, Tutt, A & De Rinaldis, E 2017, ' Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival ', Scientific Reports, vol. 7, 40177 . https://doi.org/10.1038/srep40177
Scientific Reports
Scientific Reports
Despite advancements in the use of transcriptional information to understand and classify breast cancers, the contribution of splicing to the establishment and progression of these tumours has only recently starting to emerge. Our work explores this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d07309f42176a72f2eb39b2b927aa5c
https://kclpure.kcl.ac.uk/en/publications/4afa7969-c960-47bd-ad25-04a81b2639c5
https://kclpure.kcl.ac.uk/en/publications/4afa7969-c960-47bd-ad25-04a81b2639c5
Autor:
Joy Burchell, Max S. Wicha, Sara A. Lombardi, Ireneusz Shinomiya, Gabriela Dontu, Ariel Barkan, Suling Liu, Christophe Ginestier, Gabriella Honeth, Steven Catchpole, Patrycja Gazinska, Bharath Buchupalli, Sarah E Pinder, John Brown, Anand D. Purushotham, Rebecca Marlow
Publikováno v:
Stem Cell Reports, Vol 2, Iss 6, Pp 780-793 (2014)
Stem Cell Reports
Stem Cell Reports, Elsevier, 2014, 2 (6), pp.780-793. ⟨10.1016/j.stemcr.2014.05.005⟩
Stem Cell Reports, 2014, 2 (6), pp.780-793. ⟨10.1016/j.stemcr.2014.05.005⟩
Stem Cell Reports
Stem Cell Reports, Elsevier, 2014, 2 (6), pp.780-793. ⟨10.1016/j.stemcr.2014.05.005⟩
Stem Cell Reports, 2014, 2 (6), pp.780-793. ⟨10.1016/j.stemcr.2014.05.005⟩
Summary Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells
Publikováno v:
Toxins, Vol 4, Iss 9, Pp 643-662 (2012)
Toxins; Volume 4; Issue 9; Pages: 643-662
Toxins
Toxins; Volume 4; Issue 9; Pages: 643-662
Toxins
Ochratoxin A (OTA) is considered to be a possible human urinary tract carcinogen, based largely on a rat model, but no molecular genetic changes in the rat carcinomas have yet been defined. The phosphorylated-S6 ribosomal protein is a marker indicati
Autor:
Paul S. Jones, Ana Montes, Panagiotis Karagiannis, Debra H. Josephs, Silvana Canevari, Philip J. Blower, Mano Nakamura, Sophia N. Karagiannis, Heike Lentfer, Cecilia Herraiz, Anthony Cheung, Christopher Corrigan, David Dombrowicz, Elliott Lever, Noel Downes, Matthew Fittall, Giulia Chiaruttini, Natalie Woodman, Silvia Crescioli, Mirella Georgouli, Louise Saul, Mariangela Figini, Andrew J. Beavil, Alexander Koers, Silvia Mele, Christopher Selkirk, Amy E. Gilbert, Heather J. Bax, Hannah J. Gould, Claire Barton, Giulia Pellizzari, Victoria Sanz-Moreno, Isabel Correa, Sophia Tsoka, Patrycja Gazinska, Kristina M. Ilieva, James Spicer, Marguerite G. Bracher, Tihomir Dodev, Gareth Muirhead, Frank O. Nestle
Publikováno v:
Josephs, D H, Bax, H J, Dodev, T, Georgouli, M, Nakamura, M, Pellizzari, G, Saul, L, Karagiannis, P, Cheung, A, Herraiz, C, Ilieva, K M, Correa, I, Fittall, M, Crescioli, S, Gazinska, P, Woodman, N, Mele, S, Chiaruttini, G, Gilbert, A E, Koers, A, Bracher, M, Selkirk, C, Lentfer, H, Barton, C, Lever, E, Muirhead, G, Tsoka, S, Canevari, S, Figini, M, Montes, A, Downes, N, Dombrowicz, D, Corrigan, C J, Beavil, A J, Nestle, F O, Jones, P S, Gould, H J, Sanz-Moreno, V, Blower, P J, Spicer, J F & Karagiannis, S N 2017, ' Anti-folate receptor-α IgE but not IgG recruits macrophages to attack tumors via TNFa/MCP-1 signaling ', Cancer Research, vol. 77, no. 5, pp. 1127-1141 . https://doi.org/10.1158/0008-5472.CAN-16-1829
IgE antibodies are key mediators of antiparasitic immune responses, but their potential for cancer treatment via antibody-dependent cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen–specific IgEs were reported to re