Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Oleg Iartchouk"'
Autor:
Zheng Yan, Raphael Thierry, Antoine deWeck, Claire Fabre, Felipe Correa Geyer, Joel Wagner, Oleg Iartchouk, Jeffrey A. Engelman, Beverly Nguyen, Rohan Diwanji, James Deeds, Julie Chen, Quincey Simmons, Naiyan Chen, Viviana Cremasco, Jonathan Chang, Joseph X. Zhou, Matt Hims, Yenyen Yu, Shaobu Weng, Pushpa Jayaraman, Stephanie Schwartz, David A. Ruddy, Michelle Piquet, Vera M. Ruda, Nathaniel D. Kirkpatrick, Pavitra Chikkegowda, Mirek Dostalek, Iulian Pruteanu-Malinici, Brian Minie, Glenn Dranoff, Markus Riester, Marc Pelletier, Alina Raza, Angelo Grauel, Kenzie MacIsaac, Jincheng Wu, Tyler Laszewski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Despite the increasing interest in targeting stromal elements of the tumor microenvironment, we still face tremendous challenges in developing adequate therapeutics to modify the tumor stromal landscape. A major obstacle to this is our poor understan
Autor:
Natalia Kurepina, Sam Bozeman, Maha R. Farhat, Alexander Sloutsky, James E. Galagan, Elizabeth M. Streicher, Tommie C. Victor, Razvan Sultana, Megan Murray, Karen R. Jacobson, Barry N. Kreiswirth, Hanna Nebenzahl-Guimaraes, Robin M. Warren, Christian Stolte, Dick van Soolingen, Leen Rigouts, James E. Posey, Peter Sisk, Devinder Kaur, Oleg Iartchouk
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 194, 5, pp. 621-30
Europe PubMed Central
American Journal of Respiratory and Critical Care Medicine, 194, 621-30
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
American journal of respiratory and critical care medicine
Europe PubMed Central
American Journal of Respiratory and Critical Care Medicine, 194, 621-30
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
American journal of respiratory and critical care medicine
Item does not contain fulltext RATIONALE: The development of molecular diagnostics that detect both the presence of Mycobacterium tuberculosis in clinical samples and drug resistance-conferring mutations promises to revolutionize patient care and int
Autor:
Megan Murray, Douglas Wilson, Sunali Goonesekera, Meghan A Baker, Andreas Sandgren, Nisha Broodie, Kristina Wallengren, Oleg Iartchouk, Pardis C. Sabeti
Publikováno v:
The Journal of Infectious Diseases. 205:1043-1047
Background. We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis. Methods. We compared iron intake, the frequency of SLC40A1 mutations, and interactions among these variabl
Autor:
Kimberly A Chin, Donald J. Zack, Nicholas Katsanis, Robyn Reynolds, Perciliz L. Tan, Peter A. Campochiaro, Kate T. Montgomery, Oleg Iartchouk, Stephan Ripke, Yi Yu, Betsy Campochiaro, Soumya Vemuri, Albert K. Tai, Soumya Raychaudhuri, Sivakumar Gowrisankar, Johanna M. Seddon, Mark J. Daly
Publikováno v:
Nature Genetics. 43:1232-1236
Two common variants in the gene encoding complement factor H (CFH), the Y402H substitution (rs1061170, c.1204C>T)(1-4) and the intronic rs1410996 SNP(5,6), explain 17% of age-related macular degeneration (AMD) liability. However, proof for the involv
Autor:
Christopher B. Ford, Nilofar Mohaideen, Marc Lipsitch, Rupal R. Shah, Philana Ling Lin, JoAnne L. Flynn, Sarah M. Fortune, James E. Galagan, Oleg Iartchouk, James C. Sacchettini, Thomas R. Ioerger, Michael R. Chase
Publikováno v:
Nature genetics
Mycobacterium tuberculosis (Mtb) has generated a global health catastrophe that has been compounded by the emergence of drug resistant Mtb strains. We used whole genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomolg
Autor:
Yosuf Yassin, A. Thomas Look, Michael A. Caligiuri, Jordan M. Winter, Oleg Iartchouk, Mignon L. Loh, Ralph H. Hruban, Susan P. Whitman, Mohamed Bentires-Alj, Rupinder Grewal, Scott E. Kern, Kenneth D. Swanson, D. Gary Gilliland, Benjamin G. Neel, Kate Montgomery, Marcelo Reis, Charles J. Yeo, Matthew Meyerson, Raju Kucherlapati, Heidi Greulich
Publikováno v:
Genes, Chromosomes and Cancer. 47:253-259
Germ line gain-of-function mutations in several members of the RAS/ERK pathway, including PTPN11, KRAS, and RAF1, cause the autosomal dominant genetic disorder Noonan Syndrome (NS). NS patients are at increased risk of leukemia/myeloproliferative dis
Publikováno v:
Genome Announcements
A new Lactobacillus acidophilus strain, FSI4, isolated from yogurt, was isolated and sequenced in our laboratory. Our data, although supportive of previous conclusions regarding the remarkable stability of L. acidophilus species, indicate accumulatin
Autor:
Oleg Iartchouk, Casey M Flanagan, Jordan Gurson, Clifford Wollam, Charlaine Scott, Yongwei Cao, Andrew Epp, Steven C. Slater, Stacie Gattung, Chris B. Crowell, Lori Mullin, Courtney M. Lappas, Nancy M. Miller, Fang Liu, Kathryn L. Houmiel, Carolyn Sear, Dahlia Doughty, Barry S. Goldman, Mike Allinger, Manor Askenazi, Graham Strub, Mary Blanchard, Brian P. Markelz, Conrad Halling, Caroline Lomo, Barbara A. Qurollo, Jeffrey M. Gordon, Mark Vaudin, Chris Cielo, Gregory Hinkle, Brad Goodner
Publikováno v:
Science. 294:2323-2328
Agrobacterium tumefaciens is a plant pathogen capable of transferring a defined segment of DNA to a host plant, generating a gall tumor. Replacing the transferred tumor-inducing genes with exogenous DNA allows the introduction of any desired gene int
Autor:
Megan Manion, Jonathan Liu, Heidi L. Rehm, Lisa M. Farwell, Jordan P. Lerner-Ellis, Birgit Funke, Oleg Iartchouk, Emily White, Kevin LeVan, Sivakumar Gowrisankar, Stephanie Cox
Publikováno v:
The Journal of molecular diagnostics : JMD. 12(6)
Medical sequencing for diseases with locus and allelic heterogeneities has been limited by the high cost and low throughput of traditional sequencing technologies. "Second-generation" sequencing (SGS) technologies allow the parallel processing of a l
Autor:
Heidi L. Rehm, Oleg Iartchouk, Christine E. Seidman, Jonathan G. Seidman, Daniel S. Herman, Raju Kucherlapati, G Kees Hovingh
Publikováno v:
Nature methods
Nature methods, 6(7), 507-510. Nature Publishing Group
Nature methods, 6(7), 507-510. Nature Publishing Group
To exploit contemporary sequencing technologies for targeted genetic analyses, we developed a hybridization enrichment strategy for DNA capture that uses PCR products as subgenomic traps. We applied this strategy to 115 kilobases of the human genome