Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nicholas G. Gottardo"'
Autor:
Amanda Millar, Mani Kuchibhotla, Michael D. Taylor, Dharmesh D. Bhuva, Emily J. Girard, Raelene Endersby, Marija Kojic, Christelle Adolphe, Brandon J. Wainwright, Laura A. Genovesi, Anne Bernard, James M. Olson, Caterina Brighi, Nicholas G. Gottardo, Clara Andradas, Melissa J. Davis, Matthew Singleton, Emily Hassall, Elissa Tolson
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Genome Medicine
Genome Medicine
Background Medulloblastoma (MB) is the most common malignant paediatric brain tumour and a leading cause of cancer-related mortality and morbidity. Existing treatment protocols are aggressive in nature resulting in significant neurological, intellect
Autor:
Elli Papaemmanuil, Bastiaan B. J. Tops, Torben Stamm Mikkelsen, Fanny Vandenbos, Christof M. Kramm, Nancy Bouvier, Katharina Filipski, Nagma Dalvi, Kristian W. Pajtler, Andrea Wittmann, Christine Haberler, Till Milde, Olaf Witt, Hildegard Dohmen, Martin Sill, George Jour, Matija Snuderl, Allison M. Martin, Torsten Pietsch, Antonis Kattamis, Nicholas G. Gottardo, Emmanuelle Uro-Coste, Philipp Sievers, Andreas von Deimling, Frank Alvaro, Simone Schmid, Damian Stichel, Jonas Ecker, Marcel Kool, Johannes Gojo, Lidija Kitanovski, Michal Zapotocky, Michael Delorenzo, Catherine Godfraind, Florian Selt, Alexander C Sommerkamp, Adam S. Levy, Pieter Wesseling, Evelina Miele, Lenka Krskova, Pengbo Beck, Matthias A. Karajannis, David Scheie, Jordan R. Hansford, Natalie Jäger, Karam T. Alhalabi, Andrey Korshunov, Felix Sahm, Mariëtte E.G. Kranendonk, David T.W. Jones, David Sumerauer, Chris Jones, Katja von Hoff, Heike Peterziel, Stefan M. Pfister, Dominik Sturm, Martin G. McCabe, Ina Oehme, Maria Filippidou, Claude Alain Maurage, Ingrid Øra, Till Acker
Publikováno v:
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Jones, C, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M, Sahm, F & Jones, D T W 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, no. 5, pp. 841-857 . https://doi.org/10.1007/s00401-021-02354-8
Acta Neuropathologica
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C-A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M & Sahm, F 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, no. 5, pp. 841-857 . https://doi.org/10.1007/s00401-021-02354-8
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C-A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Jones, C, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M, Sahm, F & Jones, D T W 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, no. 5, pp. 841-857 . https://doi.org/10.1007/s00401-021-02354-8
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Jones, C, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M, Sahm, F & Jones, D T W 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, pp. 841–857 . https://doi.org/10.1007/s00401-021-02354-8
Acta Neuropathologica, 142(5), 841-857. Springer Verlag
Acta Neuropathologica
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C-A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M & Sahm, F 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, no. 5, pp. 841-857 . https://doi.org/10.1007/s00401-021-02354-8
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C-A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Jones, C, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M, Sahm, F & Jones, D T W 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, no. 5, pp. 841-857 . https://doi.org/10.1007/s00401-021-02354-8
Alhalabi, K T, Stichel, D, Sievers, P, Peterziel, H, Sommerkamp, A C, Sturm, D, Wittmann, A, Sill, M, Jäger, N, Beck, P, Pajtler, K W, Snuderl, M, Jour, G, Delorenzo, M, Martin, A M, Levy, A, Dalvi, N, Hansford, J R, Gottardo, N G, Uro-Coste, E, Maurage, C A, Godfraind, C, Vandenbos, F, Pietsch, T, Kramm, C, Filippidou, M, Kattamis, A, Jones, C, Øra, I, Mikkelsen, T S, Zapotocky, M, Sumerauer, D, Scheie, D, McCabe, M, Wesseling, P, Tops, B B J, Kranendonk, M E G, Karajannis, M A, Bouvier, N, Papaemmanuil, E, Dohmen, H, Acker, T, von Hoff, K, Schmid, S, Miele, E, Filipski, K, Kitanovski, L, Krskova, L, Gojo, J, Haberler, C, Alvaro, F, Ecker, J, Selt, F, Milde, T, Witt, O, Oehme, I, Kool, M, von Deimling, A, Korshunov, A, Pfister, S M, Sahm, F & Jones, D T W 2021, ' PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum ', Acta Neuropathologica, vol. 142, pp. 841–857 . https://doi.org/10.1007/s00401-021-02354-8
Acta Neuropathologica, 142(5), 841-857. Springer Verlag
Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3b21e740f6cfda345b6f64cbf7586e
https://pure.au.dk/ws/files/274397587/Alhalabi2021_Article_PATZ1FusionsDefineANovelMolecu.pdf
https://pure.au.dk/ws/files/274397587/Alhalabi2021_Article_PATZ1FusionsDefineANovelMolecu.pdf
Autor:
Rishi S. Kotecha, Ian G Barr, Louise A. Carolan, Chris Fraser, Karen L. Laurie, Heather Tapp, Peter Jacoby, Nicholas G. Gottardo, Laurence C. Cheung, Ushma D. Wadia, Peter Richmond, Fiona Kerr, Anne L. Ryan, Christopher C Blyth
Publikováno v:
Bone Marrow Transplantation. 55:1829-1831
Autor:
Raelene Endersby, Pamela Ajuyah, Jason Stanley, Clara Andradas, Nicholas G. Gottardo, Sharon Lee, Santosh Valvi, Brooke Carline, Marie Wong, Mark J. Cowley, Jason M Dyke, Paul G Ekert, Christine L. White, Paulette Barahona, Jacqueline Whitehouse, Meegan Howlett, Chelsea Mayoh, Hilary Hii, Molly Buntine, Mani Kuchibhotla
Publikováno v:
Cancers, Vol 12, Iss 2937, p 2937 (2020)
Cancers
Volume 12
Issue 10
Cancers
Volume 12
Issue 10
Simple Summary Radiation-induced glioma (RIG) is a highly aggressive brain cancer arising as a consequence of radiation therapy, for which there is currently no effective treatment. In order to test new drugs in the hope of finding more effective the
Autor:
Michael Rusch, Aksana Vasilyeva, Marc Remke, Paul A. Northcott, Tanvi Sharma, Finn Wesenberg, Andrey Korshunov, Peter Lichter, Kristian W. Pajtler, Natalie Jäger, Sonia Partap, Till Milde, John R. Crawford, Amar Gajjar, Stefan Rutkowski, Nicholas G. Gottardo, Kyle S. Smith, Daniel C. Bowers, Christoffer Johansen, Sebastian M. Waszak, Tobias Rausch, Christelle Dufour, Damarys Loew, David T.W. Jones, Geoffrey Neale, Olaf Witt, Tone Eggen, Ivo Buchhalter, Olivier Ayrault, Dominik Sturm, Maria Feychting, Jesus Garcia-Lopez, Michael A. Grotzer, Claudia E. Kuehni, Emilie Indersie, Brandon J. Wainwright, Stéphanie Puget, Joy Nakitandwe, Marcel Kool, David W. Ellison, Marina Ryzhova, Jules Kerssemakers, Birgitta Lannering, Amy A Smith, Brent A. Orr, Joachim Schüz, Tina Veje Andersen, Murali Chintagumpala, Brian Gudenas, Bérangère Lombard, Antoine Forget, Laurence Brugières, Marija Kojic, Kim E. Nichols, Jennifer Hadley, Martin Röösli, Kristina Kjærheim, Anne Bendel, Stefan M. Pfister, Kayla V. Hamilton, Ruth G. Tatevossian, Giles W. Robinson, Jan O. Korbel
Publikováno v:
Nature
Nature, Nature Publishing Group, 2020, 580, pp.396-401. ⟨10.1038/s41586-020-2164-5⟩
Nature, Nature Publishing Group, 2020, 580, pp.396-401. ⟨10.1038/s41586-020-2164-5⟩
Cancer genomics has illuminated a wide spectrum of genes and core molecular processes contributing to human malignancy. Still, the genetic and molecular basis of many cancers remains only partially explained. Genetic predisposition accounts for 5-10%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a6e2d9961a298612513b23146265b6
https://europepmc.org/articles/PMC7430762/
https://europepmc.org/articles/PMC7430762/
Autor:
Martin U. Schuhmann, Till Milde, A. von Deimling, Matija Snuderl, Kathy Keyvani, Nada Jabado, Thorsten Pietsch, Eleonora Aronica, Olaf Witt, Christian Hartmann, David T.W. Jones, David Ellison, Felix Sahm, Martin Sill, Dominik Sturm, M Kool, M. Y. Deng, Damian Stichel, Matthias Preusser, Felice Giangaspero, K. von Hoff, M. Lauten, Christine Haberler, Ori Staszewski, Ulrich Schüller, Jonas Ecker, Pieter Wesseling, Christopher Dunham, Martin Ebinger, Jens Schittenhelm, Christel Herold-Mende, Hendrik Witt, Wolfgang Wick, Andrey Korshunov, Nicholas G. Gottardo, Dominique Figarella-Branger, Andrea Wittmann, M. Deckert, Stefan M. Pfister
Publikováno v:
Neuropathology and Applied Neurobiology
Neuropathology and Applied Neurobiology, Wiley, 2019, ⟨10.1111/nan.12590⟩
Neuropathology and Applied Neurobiology, 2019, ⟨10.1111/nan.12590⟩
Neuropathology and Applied Neurobiology, 46(5), 422-430. Wiley-Blackwell
Deng, M Y, Sill, M, Sturm, D, Stichel, D, Witt, H, Ecker, J, Wittmann, A, Schittenhelm, J, Ebinger, M, Schuhmann, M U, Figarella-Branger, D, Aronica, E, Staszewski, O, Preusser, M, Haberler, C, Lauten, M, Schüller, U, Hartmann, C, Snuderl, M, Dunham, C, Jabado, N, Wesseling, P, Deckert, M, Keyvani, K, Gottardo, N, Giangaspero, F, von Hoff, K, Ellison, D W, Pietsch, T, Herold-Mende, C, Milde, T, Witt, O, Kool, M, Korshunov, A, Wick, W, von Deimling, A, Pfister, S M, Jones, D T W & Sahm, F 2020, ' Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) – a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14 ', Neuropathology and Applied Neurobiology, vol. 46, no. 5, pp. 422-430 . https://doi.org/10.1111/nan.12590
Neuropathology and applied neurobiology. Wiley-Blackwell
Neuropathology and Applied Neurobiology, Wiley, 2019, ⟨10.1111/nan.12590⟩
Neuropathology and Applied Neurobiology, 2019, ⟨10.1111/nan.12590⟩
Neuropathology and Applied Neurobiology, 46(5), 422-430. Wiley-Blackwell
Deng, M Y, Sill, M, Sturm, D, Stichel, D, Witt, H, Ecker, J, Wittmann, A, Schittenhelm, J, Ebinger, M, Schuhmann, M U, Figarella-Branger, D, Aronica, E, Staszewski, O, Preusser, M, Haberler, C, Lauten, M, Schüller, U, Hartmann, C, Snuderl, M, Dunham, C, Jabado, N, Wesseling, P, Deckert, M, Keyvani, K, Gottardo, N, Giangaspero, F, von Hoff, K, Ellison, D W, Pietsch, T, Herold-Mende, C, Milde, T, Witt, O, Kool, M, Korshunov, A, Wick, W, von Deimling, A, Pfister, S M, Jones, D T W & Sahm, F 2020, ' Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) – a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14 ', Neuropathology and Applied Neurobiology, vol. 46, no. 5, pp. 422-430 . https://doi.org/10.1111/nan.12590
Neuropathology and applied neurobiology. Wiley-Blackwell
Aims: DNA methylation-based central nervous system (CNS) tumour classification has identified numerous molecularly distinct tumour types, and clinically relevant subgroups among known CNS tumour entities that were previously thought to represent homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dada68de9f43e11654fb7cd706be0973
https://hal.archives-ouvertes.fr/hal-02441024
https://hal.archives-ouvertes.fr/hal-02441024
Autor:
Terrance Grant Johns, Raelene Endersby, Sameer A. Greenall, Hilary Hii, Jacqueline Whitehouse, Nicholas G. Gottardo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 5, Pp 432-442 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. The survival for patients with glioblastoma remains dismal. While the cure rate for medulloblastoma exceeds 70%, this figure has s
Autor:
Michael A. Grotzer, Marina Ryzhova, Kyle S. Smith, Olaf Witt, Ivo Buchhalter, Dominic Sturm, Paul A. Northcott, David T.W. Jones, Kayla V. Hamilton, Sonia Partap, Emilie Indersie, Daniel C. Bowers, Ruth G. Tatevossian, Anne Bendel, Laurence Brugières, Till Milde, Christelle Dufour, Stefan M. Pfister, Tobias Rausch, M Remke, Jan O. Korbel, Amy M. Smith, Tanvi Sharma, Sebastian M. Waszak, Giles W. Robinson, Stefan Rutkowski, Brent A. Orr, Natalie Jäger, Andrey Korshunov, Stéphanie Puget, Olivier Ayrault, Brandon J. Wainwright, Marcel Kool, Antoine Forget, Jennifer Hadley, Marija Kojic, Kim E. Nichols, Amar Gajjar, Damarys Loew, Peter Lichter, Garcia-Lopez Jesus, Kristian W. Pajtler, John R. Crawford, Nicholas G. Gottardo, David W. Ellison, Bérangère Lombard, Brian Gudenas, Murali Chintagumpala
Publikováno v:
Neuro-Oncology
BACKGROUND Our previous analysis of established cancer predisposition genes in medulloblastoma (MB) identified pathogenic germline variants in ~5% of all patients. Here, we extended our analysis to include all protein-coding genes. METHODS Case-contr
Autor:
Dominik Sturm, David T.W. Jones, David Capper, Felipe Andreiuolo, Nicolas U. Gerber, Stefan M. Pfister, Stefan Rutkowski, Felix Sahm, Agata Rode, Marco Gessi, Torsten Pietsch, Christof M. Kramm, Nicholas G. Gottardo, Steffen Hirsch, Andreas von Deimling, Brigitte Bison
Publikováno v:
Neuro-Oncology
The large variety of CNS tumor entities affecting children and adolescents, some of which are exceedingly rare, results in very diverging patient outcomes and renders accurate diagnosis challenging. To assess the diagnostic utility of routine DNA met
Autor:
Nicholas G. Gottardo, Santosh Valvi
Publikováno v:
Brain Tumors-An Update
University of Western Australia
University of Western Australia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aed5e57829887aa403b0beb7c750f4
http://www.intechopen.com/articles/show/title/diffuse-intrinsic-pontine-glioma
http://www.intechopen.com/articles/show/title/diffuse-intrinsic-pontine-glioma