Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Nadia J. Kershaw"'
Autor:
Sharon Tran, Nadia J. Kershaw, Neil D. Young, Tiffany J Harris, Brian J. Smith, Erinna F. Lee, Merridee A. Wouters, Tatiana P. Soares da Costa, W. Douglas Fairlie, Robin B. Gasser, Marco Evangelista
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, subsequent studies showed C. elegans apoptosis has several unique features compared with human apoptosis. To date, there h
Autor:
Penny A. Handford, Sacha A. Jensen, Martin Münzel, Kirsty S. Hewitson, Christopher J. Schofield, Udo Oppermann, Nadia J. Kershaw, Grazyna Kochan, T. Krojer, Lennart Brewitz, Inga Pfeffer, Richard J. Hopkinson, Michael A. McDonough, Luke A. McNeill, Holger B. Kramer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
AspH is an endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and tetratricopeptide repeat (TPR) domains present in the ER lumen. AspH catalyses hydroxylation of asparaginyl- and aspartyl-residues in epid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5f448ad1aa45d823fa2af6baae91d5
https://ora.ox.ac.uk/objects/uuid:0a1194dd-a9fc-4cd5-9390-46c2c68e9f33
https://ora.ox.ac.uk/objects/uuid:0a1194dd-a9fc-4cd5-9390-46c2c68e9f33
Autor:
Isabelle S Lucet, Jeffrey J. Babon, Nicholas P. D. Liau, Nicos A. Nicola, Eden L Whitlock, Kimberley L. Callaghan, Shenggen Yao, Artem Laktyushin, Nadia J. Kershaw, James M. Murphy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by recruiting Cullin5 to ubiquitinate signalling components; however, SOCS1,
Autor:
Thomas J. Hayman, Jian-Guo Zhang, Nadia J. Kershaw, Tatiana B. Kolesnik, Nicos A. Nicola, Seth L. Masters, Michaela U. Gack, Jessica J. Chiang, Sandra E. Nicholson, Edmond M. Linossi, Laura F. Dagley, May K. Wang, James M. Murphy, Michael D. W. Griffin, Jeffrey J. Babon, Akshay A. D’Cruz
Publikováno v:
Biochemical Journal. 475:429-440
The retinoic acid-inducible gene-I (RIG-I) receptor recognizes short 5′-di- and triphosphate base-paired viral RNA and is a critical mediator of the innate immune response against viruses such as influenza A, Ebola, HIV and hepatitis C. This respon
Autor:
Satoshi Ishido, Andrew I. Webb, Nadia J. Kershaw, Warren S. Alexander, Jarrod J. Sandow, Nicos A. Nicola, Cyrus Tan, Douglas J. Hilton, Jeffrey J. Babon, Dina Stockwell
Publikováno v:
PROTEOMICS. 21:2000244
MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface expression of major histocompatibility complexes I and II as well as immune co-stimulatory receptors. We recently showed t
Autor:
Tatiana B. Kolesnik, Katherine Kedzierska, Michelle D. Tate, Thomas J. Hayman, Nadia J. Kershaw, Paul J. Baker, Laura F. Dagley, Nicos A. Nicola, Peter A. B. Wark, Marco Binder, Philip M. Hansbro, Lukasz Kedzierski, Sandra E. Nicholson, Seth L. Masters, Alan Hsu, Gabrielle T. Belz, Andrew I. Webb, Joschka Willemsen
Publikováno v:
Immunology and cell biologyReferences. 97(9)
The innate immune system is our first line of defense against viral pathogens. Host cell pattern recognition receptors sense viral components and initiate immune signaling cascades that result in the production of an array of cytokines to combat infe
Autor:
Cindy S. Luo, Antony W. Burgess, Michael D. W. Griffin, Nadia J. Kershaw, Nicole Church, Timothy E. Adams
Publikováno v:
ResearcherID
The Notch pathway is a fundamental signalling system in most multicellular animals. We have determined the X-ray crystal structure of the extracellular domain of the Notch ligand delta-like ligand-1 (Dll-1). The structure incorporates the N-terminal
Autor:
Lesley A.H. Bowman, Michael A. Bentley, Shoichiro Horita, Nadia J. Kershaw, Steinar M. Paulsen, Joongoo Lee, Gail M. Preston, Christoph M. Tang, Christopher J. Schofield, Nikita D. Loik, Wei Ge, Ivanhoe K. H. Leung, Chia Hua Ho, Hwanho Choi, John S. Scotti, Jordi Paps, Michael A. McDonough, Holger B. Kramer, Timothy D. W. Claridge, Wei Shen Aik
Publikováno v:
Proceedings of the National Academy of Sciences. 111:13331-13336
The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabilization, hypoxia sensing, and translational regulation. The hypoxia-inducible factor (HIF) sensing system is conserved in animals, but not in other o
Publikováno v:
Structure. 24:840-842
Janus kinases (JAKs) initiate the intracellular signaling cascade triggered by exposure of cells to cytokines and interferons. In order to achieve this, JAKs are bound to the intracellular domain of specific cytokine receptors immediately adjacent to
Autor:
Kathryn L. Kavanagh, T. Krojer, João R. C. Muniz, S.S. Ng, Michael A. McDonough, Rok Sekirnik, Nadia J. Kershaw, Wei Ge, Aidan J. Doherty, Christopher J. Schofield, Chia-hua Ho, Ewa S. Pilka, Ian J. Clifton, Rasheduzzaman Chowdhury, Udo Oppermann, Gavin C. Fox, M. Vollmar, Claire Phillips, Frank von Delft, Nigel C. Brissett
Publikováno v:
Nature
Crystal structures of human and prokaryotic ribosomal oxygenases reported here, with and without their ribosomal protein substrates, support their assignments as hydroxylases, and provide insights into the evolution of the JmjC-domain-containing hydr